SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001256426 |
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Gene Symbol: | PDLIM5 |
Description: | Homo sapiens PDZ and LIM domain 5 (PDLIM5), transcript variant 2, mRNA. |
Browse Associations |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94664155T>C | COSN1083639 | TCGA-AP-A0LM-01 | [endometrium][NS][carcinoma][endometrioid_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94664647A>G | COSN8618805 | SS6003314 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-663b |
ggtgggtGGGCCACatgag |
0 | GGUGGCCC | m7b | Created | no TS | -0.357000 |
-11.260000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94664835A>G | COSN5580950 | RK085_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-143-5p |
taccACTGCACtccagcct |
0 | GGUGCAGU | m7b | Disrupted | -0.015000 | 0.033000 |
0.010000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94664870C>A | ICGC_E94F6422-2A78-11E2-89D1-29FD496BB9B8 | CPCG_0103_Pr_P_P8 | ProstateCancer(OICR,CA) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1270 |
ctctgTCTCCAaaaaaaaa |
0 | CUGGAGAU | m6b | Disrupted | -0.085 | 0 | No effect | |
hsa-miR-129-5p |
ctctgtctcCAAAAAaaaa |
0 | CUUUUUGC | m6b | Disrupted | 0.102 | 0.111 | No effect | |
hsa-miR-3672 |
ctctGTCTCAaaaaaaaaa |
0 | AUGAGACU | m6b | Created | -0.23 | -0.287 | No effect | |
hsa-miR-4524a-3p |
ctCTGTCTCAaaaaaaaaa |
0 | UGAGACAG | m8a | (m7a->m8a) | -0.374 | -0.472 | No effect | |
hsa-miR-4531 |
ctctgTCTCCAaaaaaaaa |
0 | AUGGAGAA | m6b | Disrupted | -0.033 | 0.047 | No effect | |
hsa-miR-620 |
ctctgTCTCCAaaaaaaaa |
0 | AUGGAGAU | m6b | Disrupted | -0.082 | 0 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94665228G>A | ICGC_9C286450-2A78-11E2-8335-12FD496BB9B8 | CPCG_0102_Pr_P_P2 | ProstateCancer(OICR,CA) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4438 |
cacGCCTGTGatcccagca |
0 | CACAGGCU | m7a | (m7a->m6a) | -0.077 | -0.09 | No effect | |
hsa-miR-450b-3p |
cacgcctgtGATCCCAgca |
0 | UUGGGAUC | m7b | (m7b->m6c) | -0.008 | no TS |
0.4 |
|
hsa-miR-5089 |
cacgcctgtAATCCCAgca |
0 | GUGGGAUU | m7b | (m6c->m7b) | -0.036 | 0.027 |
-0.01 |
|
hsa-miR-5095 |
cacGCCTGTAAtcccagca |
0 | UUACAGGC | m8a | Created | -0.379 | -0.433 |
-0.02 |
|
hsa-miR-513a-5p |
cacgCCTGTGAtcccagca |
0 | UUCACAGG | m7b | Disrupted | -0.122 | -0.177 | No effect | |
hsa-miR-638 |
cacgcctgtGATCCCagca |
0 | AGGGAUCG | m6b | Disrupted | -0.038 | no TS |
0.2 |
|
hsa-miR-769-3p |
cacgcctgtGATCCCAGca |
0 | CUGGGAUC | m8a | (m8a->m7b) | -0.008 | no TS |
1.3 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94665925G>A | 9_57793 | CRC-6-Tumor | Colorectal adenocarcinoma | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-136-5p |
ccacATGGAGacagggaaa |
11 |
ACUCCAUU | m6b | Disrupted | 0.046 | no TS | No effect | |
hsa-miR-4421 |
ccacatggAGACAGGgaaa |
0 | ACCUGUCU | m7b | Disrupted | 0.024 | no TS |
0.92 |
|
hsa-miR-5581-3p |
ccaCATGGAAacagggaaa |
9 |
UUCCAUGC | m7a | (m6a->m7a) | no TS | 0.03 | No effect | |
hsa-miR-5699 |
ccacatggAGACAGGgaaa |
0 | UCCUGUCU | m7b | Disrupted | -0.004 | no TS |
0.04 |
|
hsa-miR-587 |
ccacATGGAAAcagggaaa |
10 |
UUUCCAUA | m7a | Created | -0.052 | 0.039 |
-0.01 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94665976T>C | COSN7849062 | 8068548 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1229 |
tttgcccaGTGAGAaaaca |
0 | CUCUCACC | m6b | Disrupted | 0.033000 | no TS |
0.020000 |
|
hsa-miR-1304-3p |
tttgccCAGTGAGAaaaca |
0 | UCUCACUG | m8a | Disrupted | 0.086000 | 0.027000 | No effect | |
hsa-miR-181b-3p |
tttgccCAGTGAGaaaaca |
0 | CUCACUGA | m7a | Disrupted | NA | NA |
1.490000 |
|
hsa-miR-612 |
ttTGCCCAGCgagaaaaca |
0 | GCUGGGCA | m8a | (m7a->m8a) | -0.060000 | -0.032000 |
-0.490000 |
|
hsa-miR-720 |
tttgccCAGCGAGAaaaca |
0 | UCUCGCUG | m8a | Created | no TS | -0.115000 |
-1.530000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94666738A>G | COSN5065342 | HX35T | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1277-3p |
tcttTCTACGTAttattca |
0 | UACGUAGA | m8a | Created | no TS | -0.183000 |
-6.490000 |
|
hsa-miR-3668 |
tcttTCTACATattattca |
0 | AAUGUAGA | m7b | Disrupted | -0.014000 | no TS |
0.280000 |
|
hsa-miR-369-3p |
tctttctacGTATTATTca |
0 | AAUAAUAC | m8a | (m7b->m8a) | 0.230000 | 0.362000 |
-0.540000 |
|
hsa-miR-4517 |
tctttctaCATATTattca |
0 | AAAUAUGA | m6b | Disrupted | 0.111000 | no TS |
1.400000 |
|
hsa-miR-5583-3p |
tctttctaCATATTattca |
0 | GAAUAUGG | m6b | Disrupted | 0.140000 | 0.032000 |
0.090000 |
|
hsa-miR-5692b |
tctttctacATATTATTca |
0 | AAUAAUAU | m8a | (m8a->m7b) | 0.486000 | 0.330000 |
-0.060000 |
|
hsa-miR-5692c |
tctttctacATATTATTca |
0 | AAUAAUAU | m8a | (m8a->m7b) | 0.486000 | 0.330000 |
-0.030000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.94667476A>C | COSN9246457 | AOCS-145-1-6 | [ovary][NS][other][neoplasm] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-369-3p |
gtattagcTATTATaggta |
0 | AAUAAUAC | m6b | Disrupted | 0.230000 | 0.146000 |
0.230000 |
|
hsa-miR-374a-5p |
gtattagcTATTATAggta |
0 | UUAUAAUA | m7b | Disrupted | 0.282000 | 0.189000 |
0.160000 |
|
hsa-miR-374b-5p |
gtattagcTATTATAggta |
0 | AUAUAAUA | m7b | Disrupted | 0.251000 | 0.158000 |
0.030000 |
|
hsa-miR-5692b |
gtattagcTATTATaggta |
0 | AAUAAUAU | m6b | Disrupted | 0.486000 | 0.398000 |
0.060000 |
|
hsa-miR-5692c |
gtattagcTATTATaggta |
0 | AAUAAUAU | m6b | Disrupted | 0.486000 | 0.398000 |
0.020000 |
|
hsa-miR-610 |
gtaTTAGCTCttataggta |
0 | UGAGCUAA | m7b | (m6b->m7b) | no TS | -0.203000 |
-1.130000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr4:g.94667848C>G | COSN2051794 | RK035_C01 | [liver][NS][carcinoma][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-186-5p |
taatttcTTCTTTaccccc |
0 | CAAAGAAU | m6b | Disrupted | 0.074000 | 0.041000 |
2.100000 |
hsa-miR-30a-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044000 |
-0.050000 |
hsa-miR-30b-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044000 |
-1.830000 |
hsa-miR-30c-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044000 |
-1.160000 |
hsa-miR-30d-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044000 |
-0.010000 |
hsa-miR-30e-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.053000 |
-0.060000 |
hsa-miR-186-5p |
taatttcTTCTTTaccccc |
0 | CAAAGAAU | m6b | Disrupted | 0.074 | 0.041 |
1.28 |
hsa-miR-30a-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044 |
-0.05 |
hsa-miR-30b-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044 |
-1.83 |
hsa-miR-30c-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044 |
-1.16 |
hsa-miR-30d-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.044 |
-0.01 |
hsa-miR-30e-5p |
taatttctTGTTTACcccc |
0 | UGUAAACA | m7b | Created | no TS | -0.053 |
-0.06 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
94664799 | rs1134967 | G | G |
hsa-miR-1470 hsa-miR-4287 hsa-miR-4469 hsa-miR-4667-3p hsa-miR-4685-3p hsa-miR-6867-3p hsa-miR-7113-3p |
0 |
ccgGGAGGGAgag ccgggAGGGAGAg ccggGAGGGAGAg ccgGGAGGGAgag ccgggAGGGAGAg ccgggAGGGAGAg ccgggAGGGAGAg |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.091 -0.031 -0.157 -0.074 -0.028 0.007 -0.023 |
T |
hsa-miR-136-5p |
0 |
ccgggATGGAGAg |
Created |
N |
0.006 |
|||
94664836 | rs141426145 | C | C |
hsa-miR-122-5p hsa-miR-143-5p hsa-miR-3135b hsa-miR-504-3p |
0 |
actgCACTCCAgc ACTGCACtccagc actgcaCTCCAGC actGCACTCCAgc |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.046 -0.048 -0.144 -0.204 |
T |
hsa-miR-1 hsa-miR-206 hsa-miR-3673 hsa-miR-6128 hsa-miR-613 |
0 |
actgCATTCCAgc actgCATTCCAgc actgCATTCCAgc actgcATTCCAGc actgCATTCCAgc |
Created Created Created Created Created |
N N N N N |
0.007 0.01 0.003 0.051 0.01 |
|||
94664864 | rs1056773 | C | T |
hsa-miR-4524a-3p hsa-miR-4797-5p hsa-miR-5007-5p |
0 |
agactCTGTCTCc agACTCTGTctcc AGACTCTgtctcc |
Created Created Created |
N N N |
-0.105 -0.046 -0.047 |
C |
hsa-miR-139-3p hsa-miR-4294 |
0 |
agactcCGTCTCC AGACTCCgtctcc |
Disrupted Disrupted |
N N |
-0.157 -0.061 |
|||
94667298 | rs13141591 | C | G |
hsa-miR-3654 hsa-miR-4638-3p |
0 |
atgcttGTCCAGT atgctTGTCCAGt |
Created Created |
N N |
-0.095 -0.094 |
C |
hsa-miR-4434 hsa-miR-4516 hsa-miR-4531 hsa-miR-5703 |
0 |
atgCTTCTCCAgt atgCTTCTCCAgt atgcTTCTCCAgt atgCTTCTCCAgt |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.064 -0.085 0.04 -0.085 |
|||
94667885 | rs115398076 | A | |||||||
T |
hsa-miR-30a-5p hsa-miR-30b-5p hsa-miR-30c-5p hsa-miR-30d-5p hsa-miR-30e-5p hsa-miR-4495 |
0 |
tcTGTTTACAttt tcTGTTTACAttt tcTGTTTACAttt tcTGTTTACAttt tcTGTTTACAttt tctgTTTACATtt |
Created Created Created Created Created Created |
N N N N N N |
-0.171 -0.171 -0.171 -0.171 -0.171 -0.003 |
|||
94668087 | rs140772832 | C | C |
hsa-miR-1276 hsa-miR-4311 hsa-miR-4524a-3p hsa-miR-583 |
0 |
ttctgtCTCTTTA ttctgTCTCTTTA ttCTGTCTCttta ttctgtCTCTTTA |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.08 -0.217 -0.269 -0.061 |