SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001011515
Gene Symbol: PDLIM5
Description: Homo sapiens PDZ and LIM domain 5 (PDLIM5), transcript variant 2, mRNA.
Gene Location: chr4(+):95373037-95509370
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr4:g.94587147T>G COSN5065329 HCC93 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-31-3p ttttcaactGCATAGCAaa
 4
 UGCUAUGC m8a (m7b->m8a) -0.188000 -0.496000 -4.910000
hsa-miR-3616-5p ttttcaACTTCATagcaaa
 0 AUGAAGUG m7a Disrupted NA NA -1.110000
hsa-miR-382-5p ttttCAACTTCatagcaaa
 0 GAAGUUGU m7a Disrupted NA NA 1.460000
hsa-miR-31-3p ttttcaactGCATAGCAaa
 4
 UGCUAUGC m8a (m7b->m8a) -0.188000 -0.496000 -4.910000
hsa-miR-3616-5p ttttcaACTTCATagcaaa
 0 AUGAAGUG m7a Disrupted NA NA -1.110000
hsa-miR-382-5p ttttCAACTTCatagcaaa
 0 GAAGUUGU m7a Disrupted NA NA 1.460000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.94587149A>G COSN5065331 HX29T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-31-3p ttcaacttCATAGCAaaat
 4
 UGCUAUGC m7a Disrupted -0.188000 no TS -1.330000
hsa-miR-3616-5p ttcaACTTCATagcaaaat
 0 AUGAAGUG m7a Disrupted NA NA -1.110000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.94587687C>T COSN9246448 AOCS-153-1-2 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1305 atttggctcTTGAAAAagg
 0 UUUUCAAC m7a (m6b->m7a) no TS 0.054000 -0.070000
hsa-miR-30a-3p atttggctcCTGAAAaagg
 2
 CUUUCAGU m6b Disrupted 0.021000 no TS 0.390000
hsa-miR-30d-3p atttggctcCTGAAAaagg
 2
 CUUUCAGU m6b Disrupted 0.017000 no TS 0.470000
hsa-miR-30e-3p atttggctcCTGAAAaagg
 2
 CUUUCAGU m6b Disrupted 0.021000 no TS 0.310000
hsa-miR-335-5p atttgGCTCTTGAaaaagg
 0 UCAAGAGC m8a Created no TS -0.258000 -1.570000
hsa-miR-4433-3p atttggCTCCTGaaaaagg
 2
 ACAGGAGU m6b Disrupted -0.103000 no TS 2.150000
hsa-miR-4459 atttggCTCCTGaaaaagg
 2
 CCAGGAGG m6b Disrupted -0.086000 no TS 0.070000
hsa-miR-4768-3p atttggCTCCTGaaaaagg
 2
 CCAGGAGA m6b Disrupted -0.086000 no TS 0.630000
hsa-miR-498 atttggctCTTGAAAaagg
 0 UUUCAAGC m7a Created no TS 0.010000 -10.060000
hsa-miR-505-5p attTGGCTCCtgaaaaagg
 7
 GGGAGCCA m7b (m7b->m6b) -0.220000 no TS -0.320000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.94588198T>C COSN6849989 RK144_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1295b-5p ataaCTGGGTaaaataaac
 0 CACCCAGA m6b Disrupted -0.226000 no TS 0.010000
hsa-miR-1912 ataaCTGGGTAaaataaac
 0 UACCCAGA m7a Disrupted -0.223000 no TS 0.160000
hsa-miR-2681-5p ataactgGGTAAAAtaaac
 7
 GUUUUACC m7b Disrupted -0.128000 no TS 0.020000
hsa-miR-3130-5p ataACTGGGTAaaataaac
 0 UACCCAGU m8a Disrupted -0.542000 no TS 7.080000
hsa-miR-4482-5p ataACTGGGTaaaataaac
 0 AACCCAGU m7b (m7b->m6b) -0.542000 no TS 6.210000
hsa-miR-5591-3p ataacTGGGTAaaataaac
 8
 AUACCCAU m6b Disrupted -0.221000 no TS -0.140000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
94587282 rs62316474 C C hsa-miR-29b-2-5p
hsa-miR-659-3p
7
5
 gtaAAACCAAaaa
gtaaAACCAAAaa
 Disrupted
Disrupted
N
N
 -0.106
-0.11
A hsa-miR-2681-5p
6
 GTAAAAAcaaaaa
 Created
N
 -0.027

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