SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001131027
Gene Symbol:	PDLIM4
Description:	Homo sapiens PDZ and LIM domain 4 (PDLIM4), transcript variant 2, mRNA.
Gene Location:	chr5(+):131593350-131609147
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.132272393A>G			COSN9925826		C0021T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3117-5p	tacagTAGTGTCTgcttag	0	AGACACUA	m8a	Created	no TS	-0.090000	-4.530000
hsa-miR-3166	tacagtagTGTCTGCttag	2	CGCAGACA	m7b	Created	-0.045000	-0.231000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.132272669G>T			COSN1307316		HCC39T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-361-3p	aggtgagCTGGGGGcgaga	1	UCCCCCAG	m7b	Disrupted	-0.111000	no TS	-0.010000
hsa-miR-4267	aggtGAGCTGGgggcgaga	1	UCCAGCUC	m7b	Disrupted	-0.284000	-0.161000	5.840000
hsa-miR-361-3p	aggtgagCTGGGGGcgaga	1	UCCCCCAG	m7b	Disrupted	-0.111000	no TS	-0.010000
hsa-miR-4267	aggtGAGCTGGgggcgaga	1	UCCAGCUC	m7b	Disrupted	-0.284000	-0.161000	5.840000
hsa-miR-361-3p	aggtgagCTGGGGGcgaga	1	UCCCCCAG	m7b	Disrupted	-0.111	no TS	-0.01
hsa-miR-4267	aggtGAGCTGGgggcgaga	1	UCCAGCUC	m7b	Disrupted	-0.284	-0.161	5.84

Mutation			Mutation ID		Sample Name		Cancer Type
chr5:g.132272838T>C			COSN1307318		HX12T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
132272235	rs145387656	G	G	hsa-miR-7977	1	aGCTGGGAccctg	Disrupted	N	-0.147
			A	hsa-miR-23a-5p hsa-miR-23b-5p hsa-miR-4267 hsa-miR-6512-3p hsa-miR-6720-5p hsa-miR-6823-5p	1 1 2 1 1 1	agctGGAACCCtg agctGGAACCCtg AGCTGGAaccctg aGCTGGAAccctg aGCTGGAAccctg agctggAACCCTG	Created Created Created Created Created Created	N N N N N N	-0.199 -0.19 -0.195 -0.085 -0.092 -0.081

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