SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001142772
Gene Symbol:	PCDH15
Description:	Homo sapiens protocadherin-related 15 (PCDH15), transcript variant A, mRNA.
Gene Location:	chr10(-):55562532-56561051
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53802812A>T			COSN5287345		RK101_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1257	tgcattgttATTCACTaca	0	AGUGAAUG	m7a	(m7a->m6a)	NA	NA	0.420000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53802829A>G			COSN1492689		RK007_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53802980A>C			COSN15140413		LP6005500-DNA_D01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-191-5p	tttatggTCCGTTaagcac	0	CAACGGAA	m6b	Created	no TS	-0.210000	-0.840000
hsa-miR-3619-3p	tttATGGTCCgttaagcac	0	GGGACCAU	m7b	(m6c->m7b)	no TS	-0.290000	-0.190000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53803028T>C			COSN5287346		RK030_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3129-3p	aagctTTAGTTatagactg	1	AAACUAAU	m6b	Disrupted	-0.035000	no TS	-0.040000
hsa-miR-5583-5p	aagctTTAGTTatagactg	1	AAACUAAU	m6b	Disrupted	-0.038000	no TS	-0.110000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53803048T>C			COSN5877065		RK211_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3156-5p	attttGATCTTTatcataa	0	AAAGAUCU	m7a	Disrupted	NA	NA	No effect
hsa-miR-3161	attttgatcCTTATCAtaa	3	CUGAUAAG	m7b	(m6b->m7b)	-0.124000	-0.257000	No effect
hsa-miR-541-5p	attttgATCCTTatcataa	3	AAAGGAUU	m6b	Created	-0.177000	-0.286000	-0.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53803253C>A			COSN15307467		LP6005500-DNA_A01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4263	tttaaTTAGAAaaataggc	7	AUUCUAAG	m6b	Created	0.160000	0.142000	No effect
hsa-miR-4639-5p	tttaaTTAGCAAaataggc	0	UUGCUAAG	m7a	Disrupted	-0.288000	-0.188000	No effect
hsa-miR-576-5p	tttaATTAGAAaaataggc	9	AUUCUAAU	m7b	Created	0.149000	0.014000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53803417A>T			COSN15283239		SM-4B295		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53803520T>C			COSN5287347		RK169_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53803920A>G			COSN1492690		RK089_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53804014A>G			COSN5877066		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1200	ccctgaCTCAGGAttaaaa	13	CUCCUGAG	m7b	Disrupted	-0.067000	no TS	0.010000
hsa-miR-4324	ccctgaCTCAGGattaaaa	17	CCCUGAGA	m6b	Disrupted	-0.181000	-0.161000	0.280000
hsa-miR-4740-3p	ccctgaCTCGGGattaaaa	0	GCCCGAGA	m6b	Created	no TS	-0.113000	-1.740000
hsa-miR-500a-5p	ccctgactcAGGATTAaaa	9	UAAUCCUU	m7a	(m7a->m6a)	0.028000	no TS	No effect
hsa-miR-544b	ccctgaCTCAGGattaaaa	13	ACCUGAGG	m6b	Disrupted	-0.024000	no TS	No effect
hsa-miR-5702	ccCTGACTCAggattaaaa	9	UGAGUCAG	m8a	(m8a->m7b)	-0.086000	-0.024000	0.390000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53804064T>C			COSN4714844		tumor_4108101		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53804406T>A			COSN5251946		HX30T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-579	aacCAAATGAtttgcgact	6	UUCAUUUG	m7b	(m6c->m7b)	0.106000	0.238000	-0.010000
hsa-miR-644b-3p	aacCAAATGAtttgcgact	6	UUCAUUUG	m7b	(m6c->m7b)	0.117000	0.258000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53804441A>T			COSN8712426		AOCS-117-3-3		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-320a	atgaAGCTTTagatgggaa	0	AAAAGCUG	m6b	Created	-0.071000	0.015000	-0.240000
hsa-miR-320b	atgaAGCTTTagatgggaa	0	AAAAGCUG	m6b	Created	-0.071000	0.015000	-0.230000
hsa-miR-320c	atgaAGCTTTagatgggaa	0	AAAAGCUG	m6b	Created	-0.071000	0.015000	-0.080000
hsa-miR-320d	atgaAGCTTTagatgggaa	0	AAAAGCUG	m6b	Created	-0.071000	0.015000	-0.130000
hsa-miR-4429	atgaAGCTTTagatgggaa	0	AAAAGCUG	m6b	Created	-0.071000	0.015000	No effect
hsa-miR-4509	atgaagCTTTAGatgggaa	2	ACUAAAGG	m6b	Created	-0.097000	-0.021000	No effect
hsa-miR-9-3p	atgaAGCTTTAgatgggaa	0	AUAAAGCU	m7b	Created	-0.278000	-0.211000	-0.160000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53804708C>T			0_348				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4496	catatatTTTCCTactaat	6	GAGGAAAC	m6b	Created	0.051	0.107	No effect
hsa-miR-5584-5p	catataTTTCCCTactaat	4	CAGGGAAA	m7b	Disrupted	0.002	no TS	0.28

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53804739T>C			COSN5877067		RK171_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-300	ataggatacCTTGTATAgg	2	UAUACAAG	m8a	(m7a->m8a)	0.127000	0.157000	No effect
hsa-miR-381	ataggatacCTTGTATAgg	2	UAUACAAG	m8a	(m7a->m8a)	0.127000	0.157000	No effect
hsa-miR-3973	ataggaTACTTTGTatagg	2	ACAAAGUA	m8a	Disrupted	-0.040000	-0.084000	0.020000
hsa-miR-4761-5p	ataggatACCTTGTatagg	0	ACAAGGUG	m7a	Created	NA	NA	-0.050000
hsa-miR-520d-5p	ataggataCTTTGTAtagg	2	CUACAAAG	m7b	Disrupted	0.134000	0.078000	0.220000
hsa-miR-520g	ataggatACTTTGTatagg	13	ACAAAGUG	m7a	Disrupted	-0.076000	-0.076000	No effect
hsa-miR-520h	ataggatACTTTGTatagg	13	ACAAAGUG	m7a	Disrupted	-0.076000	-0.076000	No effect
hsa-miR-524-5p	ataggataCTTTGTAtagg	2	CUACAAAG	m7b	Disrupted	0.124000	0.078000	0.010000
hsa-miR-548l	ataggATACTTTgtatagg	8	AAAAGUAU	m7b	Disrupted	0.111000	-0.066000	0.030000
hsa-miR-624-3p	ataggatACCTTGTatagg	0	CACAAGGU	m7b	Created	no TS	-0.064000	-0.160000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53805685T>A			COSN5251947		HX28T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3184-3p	tcactAGACTTTaatagtt	0	AAAGUCUC	m7a	Disrupted	NA	NA	2.770000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53805708G>T			COSN8933736		SS6003149		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3672	gttagggaAGTCTCAcatt	2	AUGAGACU	m7b	Disrupted	-0.101000	no TS	0.420000
hsa-miR-3938	gttAGGGAATTctcacatt	2	AAUUCCCU	m8a	Created	-0.144000	-0.239000	No effect
hsa-miR-580	gttagggaATTCTCAcatt	13	UUGAGAAU	m7b	Created	-0.031000	-0.056000	No effect
hsa-miR-617	gttagGGAAGTCTcacatt	2	AGACUUCC	m8a	Disrupted	-0.085000	no TS	0.020000
hsa-miR-873-3p	gttagggaAGTCTCacatt	2	GGAGACUG	m6b	Disrupted	-0.033000	no TS	0.880000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53805743A>C			COSN4714845		tumor_4102009		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-203	tagaacgacCATTTCAtaa	7	GUGAAAUG	m7b	(m6b->m7b)	0.149000	0.199000	No effect
hsa-miR-224-3p	tagaacgACCATTTcataa	0	AAAAUGGU	m7b	Created	no TS	-0.006000	-0.110000
hsa-miR-522-3p	tagaacgACCATTTcataa	0	AAAAUGGU	m7b	Created	no TS	0.003000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53805828G>C			COSN15443721		AOCS-095-1-4		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53805898C>T			COSN5877068		RK214_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1252	ttctcttgTTCCTTCatct	0	AGAAGGAA	m7b	Created	0.116000	-0.066000	-0.250000
hsa-miR-3179	ttctcttgtCCCTTCatct	0	AGAAGGGG	m6b	Disrupted	-0.100000	no TS	3.210000
hsa-miR-4475	ttctcttGTCCCTTcatct	0	CAAGGGAC	m7b	Disrupted	-0.214000	no TS	3.350000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53806056A>T			COSN6405281		HX33T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4699-3p	cacctGTAAATaattaatt	0	AAUUUACU	m6b	Disrupted	0.025000	0.003000	No effect
hsa-miR-944	cacctgtaAATAATTaatt	0	AAAUUAUU	m7b	Disrupted	-0.024000	0.000000	0.030000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53806109T>G			COSN8933737		SS6003320		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-520d-5p	ccctaaTTTGTAaaatgaa	2	CUACAAAG	m6b	Created	0.134000	0.160000	-0.050000
hsa-miR-524-5p	ccctaaTTTGTAaaatgaa	2	CUACAAAG	m6b	Created	0.124000	0.143000	-0.220000
hsa-miR-548c-3p	ccctaATTTTTaaaatgaa	3	CAAAAAUC	m6b	Disrupted	0.555000	0.431000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.53806350G>A			ICGC_DD795AAE-2A78-11E2-B303-24FD496BB9B8		CPCG_0103_Pr_P_P6		ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3646	taacctaTCATTTaaacat	0	AAAAUGAA	m6b	Created	-0.231	-0.225	0.2

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
53803035	rs10825112	T	G	hsa-miR-103a-2-5p hsa-miR-320a hsa-miR-320b hsa-miR-320c hsa-miR-320d hsa-miR-4429 hsa-miR-9-3p	0	tAAGAAGCtttag taagaAGCTTTAg taagaAGCTTTAg taagaAGCTTTAg taagaAGCTTTAg taagaAGCTTTAg taagaAGCTTTAg	Created Created Created Created Created Created Created	N N N N N N N	-0.212 -0.071 -0.071 -0.071 -0.071 -0.071 -0.164
			T	hsa-miR-4744	0	taagaaTCTTTAG	Disrupted	N	-0.199
53803253	rs11003860	T	C	hsa-miR-4639-5p hsa-miR-6885-3p	0	aaTTAGCAAaata aattAGCAAAAta	Created Created	N N	-0.1 -0.053
53803898	rs76123679	T	T	hsa-miR-384 hsa-miR-4496 hsa-miR-5571-3p hsa-miR-7975	1 5 1 1	ttttcCTAGGAAg tTTTCCTAggaag ttttCCTAGGAAg ttttcCTAGGAAg	Disrupted Disrupted Disrupted Disrupted	N N N N	0.004 0.051 -0.166 -0.051
			G	hsa-miR-1238-3p	1	ttttcCGAGGAAg	Created	N	-0.018
53804741	rs76899590	A	A	hsa-miR-3973 hsa-miR-548l	2 2	taggaTACTTTGt taggATACTTTgt	Disrupted Disrupted	N N	0.044 0.177
			C	hsa-miR-4661-3p	2	taGGATCCTttgt	Created	N	-0.151
53805867	rs191782955	T	T	hsa-miR-548a-5p hsa-miR-548ab hsa-miR-548ak hsa-miR-548am-5p hsa-miR-548ap-5p hsa-miR-548aq-5p hsa-miR-548ar-5p hsa-miR-548as-5p hsa-miR-548au-5p hsa-miR-548av-5p hsa-miR-548ay-5p hsa-miR-548b-5p hsa-miR-548c-5p hsa-miR-548d-5p hsa-miR-548h-5p hsa-miR-548i hsa-miR-548j-5p hsa-miR-548k hsa-miR-548l hsa-miR-548o-5p hsa-miR-548w hsa-miR-548y hsa-miR-559 hsa-miR-8054	1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1	agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agATACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt agaTACTTTAgtt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N N N N N N N N N N N N N	0.045 0.038 0.042 0.042 0.048 0.042 0.042 0.045 0.042 0.024 0.042 0.042 0.042 0.042 0.042 0.038 0.045 0.024 0.006 0.042 0.042 0.042 0.045 0.034
			C	hsa-miR-548ag hsa-miR-548ai hsa-miR-548ba hsa-miR-570-5p	1 1 1 1	agaTACCTTAgtt agaTACCTTAgtt agaTACCTTAgtt agaTACCTTAgtt	Created Created Created Created	N N N N	-0.039 -0.039 -0.046 -0.039
53806055	rs150258753	-	-	hsa-miR-4699-3p hsa-miR-944	0	acctGTAAATAattaatta acctgtaAATAATTAatta	Unknown Unknown	N N	0.001 0.004
			TAAT
53806539	rs200157124	-	-	hsa-miR-548c-3p	0	tttacttacATTTTTAata	Unknown	N	-0.007
			TTAC

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