SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001184790
Gene Symbol:	PARD3
Description:	Homo sapiens par-3 partitioning defective 3 homolog (C. elegans) (PARD3), transcript variant 2, mRNA.
Gene Location:	chr10(-):34398487-35104253
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.34110369A>G			COSN10066395		C0016T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-433	gtgtctATCATGAggggag	2	AUCAUGAU	m7b	Disrupted	0.045000	no TS	0.250000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.34110436G>A			COSN6069398		RK144_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2355-5p	tctgtgTGGGGAacgtggg	3	AUCCCCAG	m6b	Disrupted	-0.048000	no TS	No effect
hsa-miR-4286	tctgtGTGGGGaacgtggg	2	ACCCCACU	m6b	Disrupted	-0.078000	no TS	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.34110527C>A			COSN1486683		RK026_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2054	caacATTACAaataaagtg	1	CUGUAAUA	m6b	Created	0.050000	0.043000	-7.070000
hsa-miR-2054	caacATTACAaataaagtg	0	CUGUAAUA	m6b	Created	0.05	0.043	-7.07

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.34111155G>A			COSN15193873		LP6005334-DNA_E01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
34110605	rs80070301	A	A	hsa-miR-2054 hsa-miR-3182 hsa-miR-3607-3p hsa-miR-3686	1 1 1 1	ccTATTACAgaag cctattACAGAAG cctaTTACAGAag cctaTTACAGAAg	Disrupted Disrupted Disrupted Disrupted	N N N N	0.05 -0.12 0.009 -0.084
			G	hsa-miR-2276-3p hsa-miR-4772-3p hsa-miR-544a hsa-miR-6826-5p	1 1 1 4	cctaTTGCAGAag cctaTTGCAGAag cctatTGCAGAAg CCTATTGcagaag	Created Created Created Created	N N N N	-0.046 -0.044 -0.101 -0.097

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