SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_152745
Gene Symbol: NXPH1
Description: Homo sapiens neurexophilin 1 (NXPH1), mRNA.
Gene Location: chr7(+):8473584-8792593
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr7:g.8751855T>G COSN2241825 RK023_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-196a-3p tcacatcTGTTGCCtggaa
 14
 CGGCAACA m7b Disrupted -0.178000 no TS 10.360000
hsa-miR-4269 tcacatctgGTGCCTGgaa
 0 GCAGGCAC m7b (m6c->m7b) no TS -0.202000 0.040000
hsa-miR-4742-5p tcacatctgTTGCCTGgaa
 16
 UCAGGCAA m7b (m7b->m6c) -0.180000 no TS No effect
hsa-miR-5683 tcaCATCTGTtgcctggaa
 13
 UACAGAUG m7b (m7b->m6b) -0.168000 no TS 1.390000
hsa-miR-593-5p tcacatcTGGTGCCTggaa
 0 AGGCACCA m8a Created no TS -0.218000 -4.290000
hsa-miR-196a-3p tcacatcTGTTGCCtggaa
 14
 CGGCAACA m7b Disrupted -0.178 no TS 10.36
hsa-miR-4269 tcacatctgGTGCCTGgaa
 0 GCAGGCAC m7b (m6c->m7b) no TS -0.202 0.04
hsa-miR-4742-5p tcacatctgTTGCCTGgaa
 0 UCAGGCAA m7b (m7b->m6c) -0.18 no TS No effect
hsa-miR-5683 tcaCATCTGTtgcctggaa
 13
 UACAGAUG m7b (m7b->m6b) -0.168 no TS 1.39
hsa-miR-593-5p tcacatcTGGTGCCTggaa
 0 AGGCACCA m8a Created no TS -0.218 -4.29

Mutation Mutation ID Sample Name Cancer Type
chr7:g.8751922C>G COSN1355059 BN41T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-128 gaaaaCACTGTGAtgtaat
 0 UCACAGUG m8a Created no TS -0.354000 -0.140000
hsa-miR-27a-3p gaaaacACTGTGAtgtaat
 14
 UUCACAGU m7b Created -0.104000 -0.248000 -1.210000
hsa-miR-27b-3p gaaaacACTGTGAtgtaat
 14
 UUCACAGU m7b Created -0.104000 -0.248000 -1.070000
hsa-miR-3659 gaaAACACTCtgatgtaat
 0 UGAGUGUU m7b (m7b->m6b) -0.203000 no TS 6.020000
hsa-miR-3681-3p gaaaaCACTGTGatgtaat
 0 ACACAGUG m7b Created no TS -0.427000 -9.430000
hsa-miR-499a-3p gaaaacactGTGATGTaat
 10
 AACAUCAC m7b (m6c->m7b) -0.094000 -0.328000 -2.290000
hsa-miR-499b-3p gaaaacactGTGATGTaat
 10
 AACAUCAC m7b (m6c->m7b) -0.094000 -0.328000 -2.490000
hsa-miR-5586-3p gaaaaCACTCTGatgtaat
 0 CAGAGUGA m7a Disrupted NA NA No effect
hsa-miR-759 gaaaaCACTCTGatgtaat
 0 GCAGAGUG m7b Disrupted -0.387000 no TS 3.200000
hsa-miR-128 gaaaaCACTGTGAtgtaat
 0 UCACAGUG m8a Created no TS -0.354 -0.14
hsa-miR-27a-3p gaaaacACTGTGAtgtaat
 0 UUCACAGU m7b Created -0.104 -0.248 -1.21
hsa-miR-27b-3p gaaaacACTGTGAtgtaat
 0 UUCACAGU m7b Created -0.104 -0.248 -1.07
hsa-miR-3659 gaaAACACTCtgatgtaat
 0 UGAGUGUU m7b (m7b->m6b) -0.203 no TS 6.02
hsa-miR-3681-3p gaaaaCACTGTGatgtaat
 0 ACACAGUG m7b Created no TS -0.427 -9.43
hsa-miR-499a-3p gaaaacactGTGATGTaat
 0 AACAUCAC m7b (m6c->m7b) -0.094 -0.328 -2.29
hsa-miR-499b-3p gaaaacactGTGATGTaat
 0 AACAUCAC m7b (m6c->m7b) -0.094 -0.328 -2.49
hsa-miR-5586-3p gaaaaCACTCTGatgtaat
 0 CAGAGUGA m7a Disrupted NA NA No effect
hsa-miR-759 gaaaaCACTCTGatgtaat
 0 GCAGAGUG m7b Disrupted -0.387 no TS 3.2

Mutation Mutation ID Sample Name Cancer Type
chr7:g.8751990C>G COSN5104802 HX33T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1257 ttttgaATTCACacctgaa
 0 AGUGAAUG m6b Disrupted -0.063000 no TS 0.060000
hsa-miR-183-3p ttttgAATTCACacctgaa
 15
 GUGAAUUA m7a Disrupted -0.019000 -0.019000 0.210000
hsa-miR-4452 ttttGAATTCAcacctgaa
 0 UUGAAUUC m7b Disrupted -0.306000 -0.181000 0.160000


Mutation Mutation ID Sample Name Cancer Type
chr7:g.8752057G>A COSN9317640 8051723 [pancreas][NS][carcinoid-endocrine_tumour][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr7:g.8752694A>T COSN9773451 C0031T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3614-5p gtttaaCCAAGTGttattt
 16
 CCACUUGG m7b Disrupted -0.269000 no TS 0.600000
hsa-miR-4643 gtttaacCATGTGTtattt
 0 GACACAUG m7b Created no TS -0.212000 -4.580000
hsa-miR-4717-3p gtttaaCCATGTGTtattt
 0 ACACAUGG m8a Created no TS -0.283000 -3.300000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
8751988 rs3779355 G T hsa-miR-1257
hsa-miR-4452
0 tttgaATTCACAc
tttGAATTCAcac
 Created
Created
N
N
 -0.063
-0.125
G hsa-miR-134-5p
hsa-miR-3118
hsa-miR-3164
hsa-miR-617
hsa-miR-6505-3p
hsa-miR-6820-3p
0 tttgaAGTCACAc
tttgaAGTCACAc
tttgAAGTCACAc
tttGAAGTCAcac
tttGAAGTCAcac
tttgAAGTCACAc
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
 -0.104
-0.111
-0.269
-0.118
-0.116
-0.29

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