SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_005124
Gene Symbol:	NUP153
Description:	Homo sapiens nucleoporin 153kDa (NUP153), mRNA.
Gene Location:	chr6(-):17615268-17706818
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.17615272T>A			COSN7788517		PCSI_0080_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3658	ggaaaTCTTAAAaaaaaaa	18	UUUAAGAA	m7a	Created	-0.137000	-0.182000	-0.720000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.17615745G>A			COSN15385818		0006_CRUK_PC_0006_T2_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.17616025G>A			COSN8871424		SNUH_G10_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-142-5p	ttgtACTTTATGctggggt	0	CAUAAAGU	m8a	Created	no TS	-0.034000	-1.380000
hsa-miR-338-3p	ttgtactttATGCTGGggt	0	UCCAGCAU	m7b	(m6b->m7b)	no TS	-0.216000	-0.460000
hsa-miR-3973	ttgTACTTTGTgctggggt	2	ACAAAGUA	m8a	Disrupted	-0.053000	no TS	1.300000
hsa-miR-5590-3p	ttgtACTTTATgctggggt	0	AAUAAAGU	m7b	Created	no TS	-0.053000	-1.170000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
17615272	rs201954304	T
			A	hsa-miR-3658 hsa-miR-7856-5p	0	aaTCTTAAAaaaa aatCTTAAAAaaa	Created Created	N N	-0.045 -0.019
17616025	rs3777711	G	G	hsa-miR-3973	2	TACTTTGtgctgg	Disrupted	N	-0.053
			A	hsa-miR-142-5p hsa-miR-338-3p hsa-miR-548a-5p hsa-miR-548ab hsa-miR-548ak hsa-miR-548am-5p hsa-miR-548ap-5p hsa-miR-548aq-5p hsa-miR-548ar-5p hsa-miR-548as-5p hsa-miR-548au-5p hsa-miR-548av-5p hsa-miR-548ay-5p hsa-miR-548b-5p hsa-miR-548c-5p hsa-miR-548d-5p hsa-miR-548h-5p hsa-miR-548i hsa-miR-548j-5p hsa-miR-548k hsa-miR-548l hsa-miR-548o-5p hsa-miR-548w hsa-miR-548y hsa-miR-559 hsa-miR-5590-3p hsa-miR-8054	2 14 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2	tACTTTATgctgg tactttATGCTGG TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg TACTTTAtgctgg tACTTTATgctgg TACTTTAtgctgg	Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N N N N N N N N N N N N N N N	-0.034 -0.216 -0.017 -0.01 -0.01 -0.01 -0.01 -0.01 -0.02 -0.01 -0.01 -0.127 -0.01 -0.01 -0.01 -0.01 -0.01 -0.01 -0.01 -0.127 -0.016 -0.01 -0.01 -0.01 -0.01 -0.053 -0.127

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