SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001165972
Gene Symbol: NRG3
Description: Homo sapiens neuregulin 3 (NRG3), transcript variant 1, mRNA.
Gene Location: chr10(+):83635069-84746935
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr10:g.82985839T>A COSN1503513 RK025_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.82985850C>A NRG3_E9_UTR_3 SJHYPO021_D Hypodiploid_ALL
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1269a gtttAGTCCAaacactgtc
 0 CUGGACUG m6b Created no TS -0.148 -2.84
hsa-miR-1269b gtttAGTCCAaacactgtc
 0 CUGGACUG m6b Created no TS -0.151 -2.94
hsa-miR-3122 gtttaGTCCCAACactgtc
 9
 GUUGGGAC m8a Disrupted -0.301 -0.095 2.9
hsa-miR-3147 gtttagtCCCAACactgtc
 8
 GGUUGGGC m6b Disrupted -0.146 no TS 0.29
hsa-miR-3199 gtttAGTCCCaacactgtc
 10
 AGGGACUG m6b Disrupted -0.467 -0.299 2.21
hsa-miR-365a-5p gtttAGTCCCaacactgtc
 10
 AGGGACUU m6b Disrupted -0.291 -0.12 3.44
hsa-miR-365b-5p gtttAGTCCCaacactgtc
 10
 AGGGACUU m6b Disrupted -0.287 -0.12 0.13
hsa-miR-3913-5p gtttaGTCCCAAcactgtc
 9
 UUUGGGAC m7b Disrupted -0.292 -0.086 2.8
hsa-miR-4298 gtttaGTCCCAacactgtc
 9
 CUGGGACA m6b Disrupted -0.275 -0.104 0.66
hsa-miR-4425 gtttagTCCCAACActgtc
 7
 UGUUGGGA m8a Disrupted -0.321 no TS 9.92
hsa-miR-4529-3p gtttAGTCCAAacactgtc
 0 AUUGGACU m7b Created no TS -0.354 -4.84
hsa-miR-5009-5p gtttAGTCCAAacactgtc
 0 UUGGACUU m7a Created no TS -0.155 -0.14

Mutation Mutation ID Sample Name Cancer Type
chr10:g.82985973G>A 0_346 Small cell lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4648 ctgcaTCCCACAggtggat
 3
 UGUGGGAC m7a Created no TS -0.104 -0.15
hsa-miR-4654 ctgcATCCCACAggtggat
 3
 UGUGGGAU m8a Created no TS -0.232 -0.09
hsa-miR-4734 ctgcatCCCGCAGgtggat
 3
 GCUGCGGG m7b Disrupted -0.264 no TS 15.6
hsa-miR-4769-5p ctgcATCCCACaggtggat
 3
 GGUGGGAU m7b Created no TS -0.232 -0.38
hsa-miR-5187-5p ctgCATCCCAcaggtggat
 3
 UGGGAUGA m7a (m6a->m7a) no TS -0.096 -0.02

Mutation Mutation ID Sample Name Cancer Type
chr10:g.82986203C>T COSN6405705 HX36T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3125 gccaccTTCCTCTgagatt
 7
 UAGAGGAA m7b Disrupted -0.053000 no TS No effect
hsa-miR-3185 gccacCTTCTTCTgagatt
 0 AGAAGAAG m8a Created no TS 0.005000 -1.290000
hsa-miR-3916 gccaccTTCCTCTgagatt
 7
 AAGAGGAA m7b Disrupted -0.063000 no TS No effect
hsa-miR-4257 gccaccttCCTCTGagatt
 10
 CCAGAGGU m6b Disrupted -0.071000 no TS -6.540000
hsa-miR-4476 gccaCCTTCCTctgagatt
 2
 CAGGAAGG m7b Disrupted -0.080000 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr10:g.82986315C>T COSN5291968 RK156_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3148 aatgTTTTTCCttgagatt
 3
 UGGAAAAA m7b Disrupted -0.282000 -0.311000 No effect
hsa-miR-561-5p aatgttttTCCTTGAgatt
 3
 AUCAAGGA m7b Disrupted -0.177000 no TS 0.180000

Mutation Mutation ID Sample Name Cancer Type
chr10:g.82986526A>G COSN1503514 RK046_C02 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1200 actatTCAGGAaaattatt
 0 CUCCUGAG m6b Created no TS -0.100000 No effect
hsa-miR-3074-5p actattCAGGAAaattatt
 12
 GUUCCUGC m6b Created -0.111000 -0.190000 -0.040000
hsa-miR-3140-5p actATTCAGGaaaattatt
 15
 ACCUGAAU m7b (m6b->m7b) -0.102000 -0.303000 -0.010000
hsa-miR-378a-5p actatTCAGGAaaattatt
 0 CUCCUGAC m6b Created no TS -0.106000 -7.110000
hsa-miR-4427 acTATTCAGAaaaattatt
 6
 UCUGAAUA m8a (m8a->m7a) -0.216000 -0.149000 0.050000
hsa-miR-4680-3p actATTCAGAaaaattatt
 6
 UCUGAAUU m7a (m7a->m6a) -0.043000 -0.017000 No effect
hsa-miR-4762-3p actatTCAGAAaaattatt
 0 CUUCUGAU m6b Disrupted -0.057000 no TS 12.670000
hsa-miR-1200 actatTCAGGAaaattatt
 0 CUCCUGAG m6b Created no TS -0.1 No effect
hsa-miR-3074-5p actattCAGGAAaattatt
 0 GUUCCUGC m6b Created -0.111 -0.19 -0.04
hsa-miR-3140-5p actATTCAGGaaaattatt
 0 ACCUGAAU m7b (m6b->m7b) -0.102 -0.303 -0.01
hsa-miR-378a-5p actatTCAGGAaaattatt
 0 CUCCUGAC m6b Created no TS -0.106 -7.11
hsa-miR-4427 acTATTCAGAaaaattatt
 0 UCUGAAUA m8a (m8a->m7a) -0.216 -0.149 0.05
hsa-miR-4680-3p actATTCAGAaaaattatt
 0 UCUGAAUU m7a (m7a->m6a) -0.043 -0.017 No effect
hsa-miR-4762-3p actatTCAGAAaaattatt
 0 CUUCUGAU m6b Disrupted -0.057 no TS 12.67

Mutation Mutation ID Sample Name Cancer Type
chr10:g.82986544A>G COSN5886306 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3156-5p ttccctcttAGATCTTTtc
 0 AAAGAUCU m8a (m8a->m7b) -0.167000 no TS 1.680000


Mutation Mutation ID Sample Name Cancer Type
chr10:g.82986692C>T COSN5886307 RK150_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr10:g.82986849T>G COSN8723193 AOCS-134-3-9 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103b tagcaagtcGGCTATGtgt
 0 UCAUAGCC m7b (m6c->m7b) no TS -0.163000 -2.570000
hsa-miR-4771 tagcaAGTCTGCTatgtgt
 4
 AGCAGACU m8a Disrupted -0.251000 no TS 3.410000
hsa-miR-499b-5p tagcAAGTCTGctatgtgt
 4
 ACAGACUU m7b Disrupted -0.111000 no TS 2.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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