| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_001160005 |
|---|---|
| Gene Symbol: | NRG1 |
| Description: | Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta1c, mRNA. |
| Gene Location: | chr8(+):32405727-32600770 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr8:g.32742888A>C | COSN8576581 | tumor_4166706 | [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-1257 |
gagaaCATTCACaaaagca |
0 | AGUGAAUG | m7b | Created | no TS | -0.321000 |
-2.210000 |
| hsa-miR-2053 |
gagaacATTAACAaaagca |
8 |
GUGUUAAU | m7b | Disrupted | -0.160000 | no TS |
4.240000 |
| hsa-miR-2113 |
gagaacattCACAAAagca |
0 | AUUUGUGC | m6b | Created | no TS | -0.054000 |
-2.810000 |
| hsa-miR-3611 |
gagaacaTTCACAAaagca |
0 | UUGUGAAG | m7a | Created | no TS | -0.077000 | No effect |
| hsa-miR-409-3p |
gagAACATTCacaaaagca |
12 |
GAAUGUUG | m7a | (m6a->m7a) | -0.030000 | no TS |
0.750000 |
| hsa-miR-569 |
gagaaCATTAACaaaagca |
8 |
AGUUAAUG | m7b | Disrupted | -0.425000 | -0.174000 |
0.310000 |
| hsa-miR-758 |
gagaacatTCACAAAagca |
2 |
UUUGUGAC | m7a | Created | -0.457000 | -0.545000 |
-0.050000 |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr8:g.32743123G>A | 0_304 | Small cell lung cancer | ||||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-1265 |
ccACATCCTGaaaagggtg |
16 |
CAGGAUGU | m8a | (m8a->m7a) | -0.176 | -0.354 |
-2.23 |
| hsa-miR-2392 |
ccaCATCCTAaaaagggtg |
16 |
UAGGAUGG | m7a | (m6a->m7a) | no TS | -0.117 |
-0.56 |
| hsa-miR-30a-3p |
ccacatcCTGAAAagggtg |
17 |
CUUUCAGU | m6b | Disrupted | -0.03 | no TS |
0.28 |
| hsa-miR-30d-3p |
ccacatcCTGAAAagggtg |
17 |
CUUUCAGU | m6b | Disrupted | -0.03 | no TS |
-0.61 |
| hsa-miR-30e-3p |
ccacatcCTGAAAagggtg |
17 |
CUUUCAGU | m6b | Disrupted | -0.03 | no TS |
-0.81 |
| hsa-miR-651 |
ccacATCCTAAAaagggtg |
12 |
UUUAGGAU | m8a | Created | no TS | -0.24 |
-2.12 |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr8:g.32743224G>T | COSN1363920 | HX14T | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-4680-5p |
taataaaagGAGTTCagat |
12 |
AGAACUCU | m6b | Disrupted | -0.169000 | no TS |
4.080000 |
| hsa-miR-606 |
taataaaAGTAGTTcagat |
0 | AAACUACU | m7b | Created | no TS | -0.237000 |
-1.950000 |
| hsa-miR-4680-5p |
taataaaagGAGTTCagat |
0 | AGAACUCU | m6b | Disrupted | -0.169 | no TS |
4.08 |
| hsa-miR-606 |
taataaaAGTAGTTcagat |
0 | AAACUACU | m7b | Created | no TS | -0.237 |
-1.95 |