SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001160004
Gene Symbol: NRG1
Description: Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta1c, mRNA.
Gene Location: chr8(+):32405727-32622558
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr8:g.32763880G>A ICGC_1358824 TCGA-B5-A11E-01A-11D-A10M-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4659a-5p ttcCATGGCAGtcagcccc
 0 CUGCCAUG m8a Created no TS -0.141 -0.648
hsa-miR-4659b-5p ttcCATGGCAgtcagcccc
 0 UUGCCAUG m7b (m6b->m7b) no TS -0.141 -0.64
hsa-miR-4769-3p ttccATGGCAGtcagcccc
 0 UCUGCCAU m7b Created no TS -0.093 -0.02
hsa-miR-5002-3p ttccatGGCAGTCAgcccc
 0 UGACUGCC m8a Created no TS -0.422 -3.16


Mutation Mutation ID Sample Name Cancer Type
chr8:g.32763918T>G ICGC_1358825 TCGA-D1-A17Q-01A-11D-A12J-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr8:g.32763920G>A ICGC_SSM004800 270-01-2TD [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-597 ctacttctcGTGACACcac
 0 UGUGUCAC m7b (m7b->m6c) -0.131 no TS No effect

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32763930C>A ICGC_1358826 TCGA-BK-A139-01A-11D-A122-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-323a-5p tgacACCACCaaggctgcg
 0 AGGUGGUC m6b Disrupted -0.381 -0.234 No effect
hsa-miR-876-3p tgacACCACCAaggctgcg
 0 UGGUGGUU m7a Disrupted -0.161 no TS 1.98

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32763938C>T ICGC_1358827 TCGA-B5-A0JY-01A-11D-A10B-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-150-5p ccaaggctgTGGGAGAaga
 0 UCUCCCAA m7a (m6b->m7a) no TS -0.128 1.35
hsa-miR-188-3p ccaaggcTGTGGGAGaaga
 0 CUCCCACA m8a Created no TS -0.151 -0.37
hsa-miR-2116-3p ccaaggctgTGGGAGaaga
 0 CCUCCCAU m6b Created no TS -0.133 -5.42
hsa-miR-3156-3p ccaaggctGTGGGAGaaga
 0 CUCCCACU m7a Created NA NA 1.68
hsa-miR-4713-5p ccaaggctgTGGGAGAAga
 0 UUCUCCCA m8a (m7b->m8a) -0.116 -0.289 -0.18
hsa-miR-532-3p ccaaggctGTGGGAGaaga
 0 CCUCCCAC m7b Created no TS -0.368 -1.27

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32763997G>A ICGC_1358828 TCGA-AP-A0LM-01A-11D-A122-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147b caaccCCGCACAtgacagt
 0 GUGUGCGG m7b Created no TS -0.223 -0.82
hsa-miR-2277-5p caacCCCGCGCatgacagt
 0 AGCGCGGG m7b Disrupted -0.593 no TS 21.52
hsa-miR-3607-5p caaccccgCACATGacagt
 0 GCAUGUGA m6b Created no TS -0.034 -5.53
hsa-miR-4479 caaccCCGCGCatgacagt
 0 CGCGCGGC m6b Disrupted -0.288 no TS 4.67

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764064A>A ICGC_61680 TCGA-G2-A3IE-01A-11D-A20D-08 BladderUrothelialCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-130b-5p gaaacgaccAAAGAGTacg
 0 ACUCUUUC m7a (m6b->m7a) -0.107 -0.107 No effect
hsa-miR-635 gaaacgaCCCAAGagtacg
 0 ACUUGGGC m6b Disrupted -0.411 -0.321 -0.44
hsa-miR-9-5p gaaacgACCAAAGAgtacg
 0 UCUUUGGU m8a Created no TS -0.14 -0.56

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764099A>G ICGC_ssm_v3_32866 HCC107T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-2-5p tgttAAGAAGCTcgccaat
 0 AGCUUCUU m8a Created no TS -0.084 -7.03

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764103G>A ICGC_1358829 TCGA-D1-A16Y-01A-31D-A12J-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4710 aagaaaCTCACCaatagcc
 0 GGGUGAGG m6b Created no TS -0.114 -0.3
hsa-miR-4792 aagaaaCTCACCaatagcc
 0 CGGUGAGC m6b Created no TS -0.131 -17.58

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764125G>T ICGC_1358830 TCGA-AP-A056-01A-11W-A027-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-182-3p gggccaaaAGAACCAagcc
 0 UGGUUCUA m7a Disrupted -0.077 no TS 1.95
hsa-miR-2116-5p gggccaaAAGAACCaagcc
 0 GGUUCUUA m7a Disrupted NA NA 0.1
hsa-miR-218-1-3p gggccaaaaGAACCAagcc
 0 AUGGUUCC m6b Disrupted -0.066 no TS 2.8
hsa-miR-659-3p gggccaaaaGAACCAAGcc
 0 CUUGGUUC m8a (m8a->m7b) -0.071 no TS 1.59

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764346G>A ICGC_1358831 TCGA-A5-A0VO-01A-21D-A10G-09 UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1290 acacaggaaAAAATCCAgg
 0 UGGAUUUU m8a (m7b->m8a) 0.036 -0.013 -1.23
hsa-miR-3167 acacaggaaGAAATCCagg
 0 AGGAUUUC m7b (m7b->m6c) -0.08 0.035 2.67
hsa-miR-876-5p acacaggaaGAAATCCAgg
 0 UGGAUUUC m8a (m8a->m7b) -0.122 0.021 4.87

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764430G>A ICGC_sm120195 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125a-3p gatTCACCTGTaaaacttt
 0 ACAGGUGA m8a Disrupted -0.418 -0.167 1.76
hsa-miR-5095 gattcaCCTGTAAaacttt
 0 UUACAGGC m7a Disrupted -0.094 no TS 4.35
hsa-miR-552 gattCACCTGTaaaacttt
 0 AACAGGUG m7b Disrupted -0.704 -0.347 0.38

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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