SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001159999
Gene Symbol: NRG1
Description: Homo sapiens neuregulin 1 (NRG1), transcript variant HRG-beta1c, mRNA.
Gene Location: chr8(+):32453343-32622558
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764430G>A COSN2272614 RK027_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-125a-3p gatTCACCTGTaaaacttt
 17
 ACAGGUGA m8a Disrupted -0.338000 no TS 1.240000
hsa-miR-5095 gattcaCCTGTAAaacttt
 18
 UUACAGGC m7a Disrupted -0.165000 no TS 6.050000
hsa-miR-552 gattCACCTGTaaaacttt
 17
 AACAGGUG m7b Disrupted -0.507000 no TS 4.120000
hsa-miR-125a-3p gatTCACCTGTaaaacttt
 17
 ACAGGUGA m8a Disrupted -0.338 no TS 1.24
hsa-miR-5095 gattcaCCTGTAAaacttt
 18
 UUACAGGC m7a Disrupted -0.165 no TS 6.05
hsa-miR-552 gattCACCTGTaaaacttt
 17
 AACAGGUG m7b Disrupted -0.507 no TS 4.12

Mutation Mutation ID Sample Name Cancer Type
chr8:g.32764962A>G COSN2272615 RK082_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-103a-3p cagcATGCTGCTattaaat
 0 AGCAGCAU m8a Created no TS -0.217000 -3.140000
hsa-miR-107 cagcATGCTGCTattaaat
 0 AGCAGCAU m8a Created no TS -0.217000 -1.740000
hsa-miR-15a-5p cagcaTGCTGCTAttaaat
 0 UAGCAGCA m8a Created no TS -0.452000 -3.850000
hsa-miR-15b-5p cagcaTGCTGCTAttaaat
 0 UAGCAGCA m8a Created no TS -0.452000 -7.950000
hsa-miR-16-5p cagcaTGCTGCTAttaaat
 0 UAGCAGCA m8a Created no TS -0.421000 -4.450000
hsa-miR-195-5p cagcaTGCTGCTAttaaat
 0 UAGCAGCA m8a Created no TS -0.421000 -4.450000
hsa-miR-424-5p cagcaTGCTGCTattaaat
 0 CAGCAGCA m7b Created no TS -0.463000 -4.270000
hsa-miR-4524a-5p cagcatGCTGCTATtaaat
 0 AUAGCAGC m8a Created no TS -0.311000 -5.200000
hsa-miR-4524b-5p cagcatGCTGCTATtaaat
 0 AUAGCAGC m8a Created no TS -0.311000 -5.200000
hsa-miR-497-5p cagcaTGCTGCTattaaat
 0 CAGCAGCA m7b Created no TS -0.452000 -9.450000
hsa-miR-633 cagcatgctACTATTAaat
 13
 CUAAUAGU m7b (m7b->m6c) -0.209000 -0.045000 0.690000
hsa-miR-646 cagcatGCTGCTattaaat
 0 AAGCAGCU m6b Created no TS -0.196000 -12.500000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
32764966 rs13250952 T T hsa-miR-633
13
 ctACTATTAAata
 Disrupted
N
 -0.209
G hsa-miR-325
hsa-miR-3923
hsa-miR-4699-3p
16
16
4
 CTACTAGtaaata
cTACTAGTAaata
ctactAGTAAATA
 Created
Created
Created
N
N
N
 -0.212
-0.378
-0.147

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