SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_003822
Gene Symbol:	NR5A2
Description:	Homo sapiens nuclear receptor subfamily 5, group A, member 2 (NR5A2), transcript variant 2, mRNA.
Gene Location:	chr1(+):199996769-200146550
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.200174397A>G			COSN7983180		PCSI_0083_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4643	aaatgATGTGTCagggtat	0	GACACAUG	m7a	Created	-0.167000	-0.167000	-0.070000
hsa-miR-4732-3p	aaatgatgtGTCAGGGtat	15	GCCCUGAC	m7b	(m6c->m7b)	-0.039000	-0.344000	-0.230000
hsa-miR-642a-3p	aaatgATGTGTCagggtat	1	AGACACAU	m7b	Created	-0.020000	-0.298000	-0.030000
hsa-miR-642b-3p	aaatgATGTGTCagggtat	1	AGACACAU	m7b	Created	-0.020000	-0.298000	-0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.200176103G>C			COSN7197747		8061178		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3616-5p	cattCACTTCATtaaatgt	0	AUGAAGUG	m8a	Created	no TS	-0.118000	-1.520000
hsa-miR-4795-5p	cattCACTTCattaaatgt	0	AGAAGUGG	m6b	Created	no TS	-0.033000	-1.890000
hsa-miR-573	cattCACTTCAttaaatgt	0	CUGAAGUG	m7b	Created	no TS	-0.109000	-5.790000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.200176119A>G			COSN5363411		RK272_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4699-5p	tgtctgtaAATCTTCatca	0	AGAAGAUU	m7b	Disrupted	0.030000	0.037000	1.000000
hsa-miR-600	tgtCTGTAAGTcttcatca	0	ACUUACAG	m8a	Created	no TS	-0.031000	0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
200175377	rs35324783	-	-	hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-4271 hsa-miR-450a-2-3p hsa-miR-4699-5p hsa-miR-4725-3p hsa-miR-6763-5p hsa-miR-6780b-5p hsa-miR-6810-5p hsa-miR-6857-5p	17 21 15 21 10 15 21 15 21 21	aaatcTTCCCCAA aaatctTCCCCAA aaatCTTCCCCAa aaatctTCCCCAA aAATCTTCcccaa aaatCTTCCCCAa aaatctTCCCCAA aaatCTTCCCCAa aaatctTCCCCAA aaatctTCCCCAA	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N N	-0.07 -0.048 -0.071 -0.105 -0.007 -0.068 -0.048 -0.072 -0.062 -0.057
			C	hsa-miR-1275 hsa-miR-4525 hsa-miR-4665-5p hsa-miR-4723-5p hsa-miR-5010-5p hsa-miR-5698 hsa-miR-625-5p hsa-miR-6870-5p hsa-miR-7111-5p	21 21 21 21 21 21 17 21 21	aaatctTCCCCCAa aaatctTCCCCCAa aaatctTCCCCCAa aaatctTCCCCCAa aaatctTCCCCCAa aaatctTCCCCCAa aaatcTTCCCCCAa aaatctTCCCCCAa aaatctTCCCCCAa	Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown	N N N N N N N N N	-0.221 -0.11 -0.242 -0.102 -0.11 -0.106 -0.176 -0.096 -0.099
200176405	rs2246209	A
			A	hsa-miR-4699-5p hsa-miR-8060	0	ATCTTCAtggctc atCTTCATGgctc	Disrupted Disrupted	N N	0.044 -0.032

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