SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_021005
Gene Symbol: NR2F2
Description: Homo sapiens nuclear receptor subfamily 2, group F, member 2 (NR2F2), transcript variant 2, mRNA.
Gene Location: chr15(+):96874110-96883492
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr15:g.96337957G>A COSN7255992 8057714 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-150-5p ggagaTTGGGAGAcaatta
 13
 UCUCCCAA m8a Disrupted -0.314000 no TS 3.870000
hsa-miR-2116-3p ggagatTGGGAGacaatta
 13
 CCUCCCAU m6b Disrupted -0.147000 no TS 0.280000
hsa-miR-4713-5p ggagatTGGGAGAcaatta
 13
 UUCUCCCA m7b Disrupted -0.220000 no TS 0.270000
hsa-miR-511 ggagattggAAGACAatta
 2
 GUGUCUUU m6b Created -0.305000 -0.369000 No effect
hsa-miR-532-3p ggagatTGGGAGacaatta
 13
 CCUCCCAC m6b Disrupted -0.139000 no TS 0.220000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.96337988->T ICGC_sm132711 RK026_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-548u aagtaAGTCTTTttttttt
 0 CAAAGACU m7b Disrupted -0.316000 -0.317000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr15:g.96338175A>G COSN1691077 RK184_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1263 tccatgaaaGTACCATagg
 0 AUGGUACC m7a (m6b->m7a) NA NA -6.310000
hsa-miR-335-3p tccATGAAAAtaccatagg
 13
 UUUUUCAU m7b (m7b->m6b) 0.159000 0.128000 0.010000
hsa-miR-5579-5p tccatgaaaGTACCATAgg
 2
 UAUGGUAC m8a (m7b->m8a) -0.077000 -0.274000 No effect
hsa-miR-5681b tccatgaaAATACCatagg
 2
 AGGUAUUG m6b Disrupted -0.107000 -0.042000 2.570000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.96338582G>T COSN8483457 AOCS-004-1-5 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-205-3p aataccatTGAAATCagca
 0 GAUUUCAG m7a Disrupted NA NA 4.920000
hsa-miR-224-3p aatACCATTTaaatcagca
 0 AAAAUGGU m7b (m6b->m7b) no TS -0.108000 -1.380000
hsa-miR-4694-3p aataCCATTTaaatcagca
 0 CAAAUGGA m6b Created no TS -0.007000 -0.410000
hsa-miR-522-3p aatACCATTTaaatcagca
 0 AAAAUGGU m7b (m6b->m7b) no TS -0.150000 -4.100000


Mutation Mutation ID Sample Name Cancer Type
chr15:g.96338898G>T COSN8179179 ASHPC_0005_Pa_P_1 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr15:g.96339386A>T COSN9642027 C0083T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-15b-3p ttcagTGATTCaggttcta
 20
 CGAAUCAU m6b Created 0.014000 0.005000 -2.690000
hsa-miR-3140-5p ttcagtgATTCAGGTtcta
 0 ACCUGAAU m8a Created no TS -0.054000 -6.660000
hsa-miR-34b-3p ttcAGTGATTcaggttcta
 0 CAAUCACU m7b (m6b->m7b) no TS -0.004000 -2.900000
hsa-miR-5187-3p ttcagtGATTCAGgttcta
 2
 ACUGAAUC m7b Created -0.172000 -0.255000 -4.390000
hsa-miR-649 ttcagtgatACAGGTTcta
 0 AAACCUGU m7b (m7b->m6c) -0.124000 no TS 1.830000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.96339808A>C 12_69 NA [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3940-5p ttcCAACCCACccccccac
 0 GUGGGUUG m8a Disrupted -0.077 no TS 4.6
hsa-miR-4507 ttcCAACCCAcccccccac
 0 CUGGGUUG m7b (m7b->m6b) -0.077 no TS 0.01
hsa-miR-4651 ttccaacCCACCCCcccac
 0 CGGGGUGG m7b Disrupted -0.31 -0.164 No effect
hsa-miR-608 ttccaacCCACCCCcccac
 0 AGGGGUGG m7b Disrupted -0.338 -0.164 1.32
hsa-miR-3940-5p ttcCAACCCACccccccac
 2
 GUGGGUUG m8a Disrupted -0.077000 no TS 4.600000
hsa-miR-4507 ttcCAACCCAcccccccac
 2
 CUGGGUUG m7b (m7b->m6b) -0.077000 no TS 0.010000
hsa-miR-4651 ttccaacCCACCCCcccac
 1
 CGGGGUGG m7b Disrupted -0.310000 -0.164000 No effect
hsa-miR-608 ttccaacCCACCCCcccac
 1
 AGGGGUGG m7b Disrupted -0.338000 -0.164000 1.320000

Mutation Mutation ID Sample Name Cancer Type
chr15:g.96339930T>A COSN9642028 C0014T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-126-5p acgtTAATAATcagatcca
 0 CAUUAUUA m7b Created no TS 0.006000 -0.210000
hsa-miR-29a-5p acgttaatAATCAGatcca
 19
 ACUGAUUU m6b Created -0.031000 -0.089000 No effect
hsa-miR-3920 acgttaaTAATCAGatcca
 0 ACUGAUUA m7b Created no TS -0.280000 -3.220000
hsa-miR-4427 acgttaaTATTCAGAtcca
 0 UCUGAAUA m8a Disrupted -0.212000 -0.003000 0.170000
hsa-miR-5187-3p acgttaatATTCAGatcca
 2
 ACUGAAUC m6b Disrupted -0.172000 -0.101000 0.080000
hsa-miR-5585-3p acgttaaTATTCAGatcca
 2
 CUGAAUAG m7a Disrupted 0.030000 0.030000 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
96338747 rs78767056 T T hsa-miR-4432
hsa-miR-548u
hsa-miR-7161-5p
19
21
21
 gtcGAGTCTTtgt
gtcgAGTCTTTgt
gtcgAGTCTTTgt
 Disrupted
Disrupted
Disrupted
N
N
N
 -0.02
0.061
0.07
96339047 rs34378246 - - hsa-miR-1293
hsa-miR-299-5p
hsa-miR-4483
hsa-miR-4651
hsa-miR-608
hsa-miR-876-3p
12
11
12
16
16
12
 agtaaACCACCCc
aGTAAACCAcccc
agtaaACCACCCc
agtaaaCCACCCC
agtaaaCCACCCC
agtaAACCACCcc
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
 -0.127
-0.017
-0.109
-0.059
-0.05
-0.081
C hsa-miR-629-5p
hsa-miR-6756-5p
hsa-miR-6766-5p
hsa-miR-6769a-5p
hsa-miR-6769b-5p
hsa-miR-6793-5p
hsa-miR-6839-3p
12
16
16
12
12
12
12
 agTAAACCCAcccc
agtaaaCCCACCCc
agtaaaCCCACCCc
agtaaACCCACCcc
agtaaACCCACCcc
agtaAACCCACccc
agtAAACCCAcccc
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
 0.02
-0.116
-0.153
-0.09
-0.099
-0.047
-0.014
96339711 rs149422031 A A hsa-miR-3145-5p
hsa-miR-4432
hsa-miR-519d-5p
hsa-miR-548u
hsa-miR-7161-5p
2
3
2
3
3
 ttTTGGAGTcttt
ttttgGAGTCTTt
tTTTGGAGtcttt
ttttggAGTCTTT
ttttggAGTCTTT
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.194
-0.19
-0.142
-0.069
-0.078
G hsa-miR-3667-5p
3
 ttttgGGGTCTTt
 Created
N
 -0.219
96339804 rs148596849 - - hsa-miR-3940-5p
hsa-miR-3978
hsa-miR-4507
hsa-miR-6769a-5p
hsa-miR-6769b-5p
hsa-miR-6793-5p
2
5
2
1
1
1
 tttcCAACCCAcc
TTTCCAAcccacc
tttcCAACCCAcc
tttccaACCCACC
tttccaACCCACC
tttccAACCCACc
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
 -0.077
-0.003
-0.077
-0.154
-0.144
-0.091
C hsa-miR-193b-5p
hsa-miR-3170
hsa-miR-6742-5p
hsa-miR-6855-5p
1
1
1
1
 tttccAACCCCAcc
tttccAACCCCAcc
tttccaACCCCACc
tttccAACCCCAcc
 Unknown
Unknown
Unknown
Unknown
N
N
N
N
 -0.087
-0.067
-0.154
-0.058

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