SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_002463
Gene Symbol:	MX2
Description:	Homo sapiens myxovirus (influenza virus) resistance 2 (mouse) (MX2), mRNA.
Gene Location:	chr21(+):42733949-42780869
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.41408685G>A			COSN7146721		8068564		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-136-5p	taagtgATGGAGatacctg	3	ACUCCAUU	m6b	Disrupted	-0.099000	no TS	0.010000
hsa-miR-141-5p	taagtgatGAAGATacctg	0	CAUCUUCC	m6b	Created	no TS	-0.037000	-4.610000

Mutation			Mutation ID		Sample Name		Cancer Type
chr21:g.41408687G>A			COSN7146722		8068564		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-136-5p	agtgATGGAGatacctgag	3	ACUCCAUU	m6b	Disrupted	-0.099000	no TS	0.010000
hsa-miR-4678	agtgatggaAATACCTgag	0	AAGGUAUU	m7b	(m6c->m7b)	no TS	-0.122000	-0.450000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
41408683	rs76385948	T	T	hsa-miR-136-5p hsa-miR-6884-3p	3 2	aagtgATGGAGAt aaGTGATGGAgat	Disrupted Disrupted	N N	-0.099 -0.331
			C	hsa-miR-3605-3p	3	aagtgACGGAGAt	Created	N	-0.204

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