SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001114185
Gene Symbol:	MVK
Description:	Homo sapiens mevalonate kinase (MVK), transcript variant 1, mRNA.
Gene Location:	chr12(+):110011499-110035071
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.109596949G>A			COSN7309752		8066470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-425-3p	tggTTCCCGAagaagtgtg	0	AUCGGGAA	m7b	(m6b->m7b)	no TS	-0.322000	-4.400000
hsa-miR-4497	tggtTCCCGGAGaagtgtg	1	CUCCGGGA	m8a	Disrupted	-0.473000	-0.215000	No effect
hsa-miR-4778-3p	tggttcccGAAGAAGtgtg	0	UCUUCUUC	m7b	Created	no TS	-0.015000	-0.330000

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.109597155G>A			COSN1556969		RK061_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1280	ccggaggCGGTGGGcctgg	0	UCCCACCG	m7b	Disrupted	-0.506000	-0.357000	2.480000
hsa-miR-1281	ccGGAGGCGAtgggcctgg	1	UCGCCUCC	m8a	(m7a->m8a)	-0.376000	-0.627000	-0.030000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
109596948	rs146379014	G	G	hsa-miR-4497	3	gtTCCCGGAgaag	Disrupted	N	-0.258
			A	hsa-miR-1292-5p hsa-miR-204-3p hsa-miR-3191-5p hsa-miR-3192-5p hsa-miR-326 hsa-miR-330-5p hsa-miR-4314 hsa-miR-4471 hsa-miR-4646-5p hsa-miR-518c-5p hsa-miR-619-5p hsa-miR-6506-5p hsa-miR-6764-3p hsa-miR-6824-3p hsa-miR-8059 hsa-miR-942-5p	3 3 2 3 2 2 3 3 3 2 3 3 2 2 3 8	GTTCCCAgagaag gTTCCCAGAgaag gttcCCAGAGAAg gtTCCCAGAgaag gttCCCAGAGAag gttCCCAGAGAag gtTCCCAGAgaag GTTCCCAgagaag gTTCCCAGAgaag gttcCCAGAGAag gtTCCCAGAgaag gtTCCCAGAgaag gttcCCAGAGAag gttcCCAGAGAag GTTCCCAgagaag gttcccAGAGAAG	Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created Created	N N N N N N N N N N N N N N N N	-0.115 -0.19 -0.2 -0.071 -0.321 -0.3 -0.129 -0.104 -0.179 -0.094 -0.081 -0.06 -0.099 -0.109 -0.097 -0.029

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