SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001018116
Gene Symbol: MURC
Description: Homo sapiens muscle-related coiled-coil protein (MURC), mRNA.
Gene Location: chr9(+):103340335-103350173
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr9:g.100586468T>A COSN15314125 SNUH_G76_S1 [haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-154-5p ttaagtATAACCTAaatat
 0 UAGGUUAU m8a Created no TS 0.000000 No effect
hsa-miR-651 ttaagtatATCCTAAAtat
 0 UUUAGGAU m8a Disrupted -0.389000 no TS 3.020000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.100586493G>C COSN8519727 J73_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1243 cctaatcATCCAGTTttag
 0 AACUGGAU m8a Created no TS -0.274000 -1.050000
hsa-miR-1255a cctaaTCATCCagttttag
 0 AGGAUGAG m6b Created no TS -0.168000 -2.320000
hsa-miR-1255b-5p cctaaTCATCCagttttag
 0 CGGAUGAG m6b Created no TS -0.168000 -1.270000
hsa-miR-217 cctaatcATGCAGTtttag
 4
 UACUGCAU m7b Disrupted -0.230000 no TS 0.370000
hsa-miR-548av-3p cctaatcatGCAGTTTTag
 4
 AAAACUGC m8a (m8a->m7b) -0.229000 no TS 3.410000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.100587064C>T COSN4943317 PD3904a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-146a-3p gaagcacacTCAGAGaaaa
 0 CCUCUGAA m6b Created no TS -0.068000 -0.890000
hsa-miR-301a-5p gaagcacacTCAGAGaaaa
 0 GCUCUGAC m6b Created no TS -0.069000 0.210000
hsa-miR-3191-5p gaagcacacCCAGAGAaaa
 4
 CUCUCUGG m7b (m7b->m6c) -0.189000 -0.034000 2.740000
hsa-miR-326 gaagcacaCCCAGAGaaaa
 0 CCUCUGGG m7b Disrupted -0.307000 no TS 3.480000
hsa-miR-330-5p gaagcacaCCCAGAGAaaa
 0 UCUCUGGG m8a Disrupted -0.307000 no TS 1.500000
hsa-miR-3921 gaagcacaCTCAGAGAaaa
 3
 UCUCUGAG m8a Created -0.027000 -0.249000 -3.290000
hsa-miR-4314 gaagcacaCCCAGAGaaaa
 0 CUCUGGGA m7a Disrupted NA NA No effect
hsa-miR-4455 gaagCACACCCagagaaaa
 2
 AGGGUGUG m7b Disrupted -0.557000 -0.264000 0.710000
hsa-miR-4653-5p gaagcacaCTCAGAGAaaa
 3
 UCUCUGAG m8a Created -0.055000 -0.319000 0.670000
hsa-miR-4658 gaagcACACTCAgagaaaa
 2
 GUGAGUGU m7b Created -0.099000 -0.173000 -1.000000
hsa-miR-518c-5p gaagcacacCCAGAGAaaa
 4
 UCUCUGGA m7a (m7a->m6b) -0.087000 no TS 0.130000
hsa-miR-574-5p gaagCACACTCAgagaaaa
 0 UGAGUGUG m8a Created no TS -0.243000 -7.420000
hsa-miR-609 gaagcACACCCagagaaaa
 0 AGGGUGUU m6b Disrupted -0.117000 no TS 0.090000
hsa-miR-648 gaaGCACACTcagagaaaa
 0 AAGUGUGC m7b (m6b->m7b) no TS -0.156000 -0.080000

Mutation Mutation ID Sample Name Cancer Type
chr9:g.100587076A>G COSN1370840 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3188 gagaaaacAAGCCTCatca
 2
 AGAGGCUU m7b Disrupted -0.356000 -0.141000 1.410000
hsa-miR-485-5p gagaaaacaAGCCTCatca
 2
 AGAGGCUG m6b Disrupted -0.379000 -0.304000 No effect
hsa-miR-3188 gagaaaacAAGCCTCatca
 0 AGAGGCUU m7b Disrupted -0.356 -0.141 1.41
hsa-miR-485-5p gagaaaacaAGCCTCatca
 0 AGAGGCUG m6b Disrupted -0.379 -0.304 No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.100587097->A cosmic_v64_1870281 NA [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-129-5p tcctcCAAAAAcagaatgga
 0 CUUUUUGC m6b Created NA NA -0.010000
hsa-miR-19a-5p tcctcCAAAACagaatgga
 1
 AGUUUUGC m6b Disrupted 0.046000 0.017000 No effect
hsa-miR-19b-1-5p tcctcCAAAACagaatgga
 1
 AGUUUUGC m6b Disrupted 0.046000 0.017000 No effect
hsa-miR-19b-2-5p tcctcCAAAACagaatgga
 1
 AGUUUUGC m6b Disrupted 0.046000 0.017000 No effect
hsa-miR-4652-3p tcctccaaAACAGAAtgga
 0 GUUCUGUU m7b Disrupted -0.009000 -0.020000 No effect
hsa-miR-4778-5p tcctccaaaACAGAATgga
 0 AAUUCUGU m7b (m7b->m6c) -0.124000 -0.125000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr9:g.100587384G>T 0_337 Prostate cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-802 taaaatTGTTACTatgttt
 5
 CAGUAACA m7b Created no TS -0.23 -1.92

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
100586468 rs190889727 T T hsa-miR-651-5p
2
 agtatATCCTAAA
 Disrupted
N
 -0.389
A hsa-miR-154-5p
hsa-miR-6509-5p
2
2
 agtATAACCTAaa
agtataACCTAAA
 Created
Created
N
N
 No Change
-0.145
100586497 rs115947662 T T hsa-miR-217
hsa-miR-548a-3p
hsa-miR-548ar-3p
hsa-miR-548av-3p
hsa-miR-548az-3p
hsa-miR-548e-3p
hsa-miR-548f-3p
hsa-miR-5582-3p
hsa-miR-6807-3p
4
3
3
4
3
3
3
3
4
 ATGCAGTtttagt
atgCAGTTTTAgt
atgCAGTTTTAgt
atGCAGTTTtagt
atgCAGTTTTAgt
atgCAGTTTTAgt
atgCAGTTTTAgt
atgcAGTTTTAgt
ATGCAGTtttagt
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
N
 -0.23
-0.199
-0.188
-0.229
-0.157
-0.167
-0.188
-0.004
-0.212
C hsa-miR-320a
hsa-miR-320b
hsa-miR-320c
hsa-miR-320d
hsa-miR-4429
hsa-miR-9-3p
3
3
3
3
3
3
 atgCAGCTTTAgt
atgCAGCTTTAgt
atgCAGCTTTAgt
atgCAGCTTTAgt
atgCAGCTTTAgt
atgcAGCTTTAgt
 Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
 -0.294
-0.294
-0.294
-0.294
-0.294
-0.099

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