SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000139
Gene Symbol: MS4A2
Description: Homo sapiens membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) (MS4A2), mRNA.
Gene Location: chr11(+):59856136-59865940
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr11:g.60095691A>G COSN8686300 AOCS-104-1-6 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-212-5p ttcacaGCCAAGGatccag
 3
 ACCUUGGC m7b Disrupted -0.648000 -0.212000 No effect
hsa-miR-3189-3p ttcacagCCAAGGatccag
 1
 CCCUUGGG m6b Disrupted -0.142000 no TS 0.030000
hsa-miR-362-5p ttcacagcCAAGGATccag
 1
 AAUCCUUG m7b Disrupted -0.080000 0.014000 No effect
hsa-miR-4638-5p ttcacAGCCGAGgatccag
 1
 ACUCGGCU m7b Created -0.147000 -0.398000 -2.120000
hsa-miR-4687-3p ttcACAGCCAaggatccag
 3
 UGGCUGUU m7a (m7a->m6a) -0.160000 no TS -0.110000
hsa-miR-500b ttcacagcCAAGGATccag
 1
 AAUCCUUG m7b Disrupted -0.090000 0.014000 No effect
hsa-miR-647 ttcaCAGCCAaggatccag
 3
 GUGGCUGC m6b Disrupted -0.275000 -0.123000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr11:g.60095731A>G COSN7015562 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-145-5p ggctACTGGAaaaatttct
 3
 GUCCAGUU m6b Disrupted -0.127000 no TS 0.090000
hsa-miR-3180-5p ggctaCTGGAAaaatttct
 2
 CUUCCAGA m6b Disrupted -0.175000 -0.074000 3.770000
hsa-miR-4446-5p ggctactGGGAAAatttct
 3
 AUUUCCCU m6b Created -0.084000 -0.185000 No effect
hsa-miR-4712-5p ggcTACTGGAaaaatttct
 3
 UCCAGUAC m7a (m7a->m6a) -0.148000 no TS 0.010000
hsa-miR-5195-3p ggctACTGGAaaaatttct
 3
 AUCCAGUU m6b Disrupted -0.120000 no TS 0.020000
hsa-miR-770-5p ggcTACTGGAaaaatttct
 3
 UCCAGUAC m7a (m7a->m6a) -0.145000 no TS 0.750000

Mutation Mutation ID Sample Name Cancer Type
chr11:g.60095751C>T COSN1135314 BN50T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4531 ttcTCTCCATagcctgctg
 4
 AUGGAGAA m7a (m6a->m7a) -0.416000 -0.416000 0.320000
hsa-miR-620 ttcTCTCCATagcctgctg
 2
 AUGGAGAU m7a (m6a->m7a) -0.123000 -0.123000 0.330000
hsa-miR-4531 ttcTCTCCATagcctgctg
 4
 AUGGAGAA m7a (m6a->m7a) -0.416000 -0.416000 0.320000
hsa-miR-620 ttcTCTCCATagcctgctg
 2
 AUGGAGAU m7a (m6a->m7a) -0.123000 -0.123000 0.330000
hsa-miR-4531 ttcTCTCCATagcctgctg
 4
 AUGGAGAA m7a (m6a->m7a) -0.416000 -0.416000 0.320000
hsa-miR-620 ttcTCTCCATagcctgctg
 2
 AUGGAGAU m7a (m6a->m7a) -0.123000 -0.123000 0.330000
hsa-miR-4531 ttcTCTCCATagcctgctg
 0 AUGGAGAA m7a (m6a->m7a) -0.416 -0.416 0.32
hsa-miR-620 ttcTCTCCATagcctgctg
 0 AUGGAGAU m7a (m6a->m7a) -0.123 -0.123 0.33

Mutation Mutation ID Sample Name Cancer Type
chr11:g.60096075A>G COSN5915567 RK119_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1193 atgatttgtACCATCCacc
 0 GGGAUGGU m7b (m7b->m6c) -0.297000 -0.112000 1.090000
hsa-miR-150-3p atgattTGTACCAtccacc
 0 CUGGUACA m7b Disrupted -0.170000 no TS 0.010000
hsa-miR-183-5p atgatttGTGCCATccacc
 0 UAUGGCAC m7b Created no TS -0.165000 -0.020000
hsa-miR-4719 atgATTTGTGccatccacc
 4
 UCACAAAU m7b (m6b->m7b) -0.221000 -0.181000 0.120000
hsa-miR-5579-5p atgatttGTACCATccacc
 0 UAUGGUAC m7b Disrupted -0.140000 no TS 2.030000


Mutation Mutation ID Sample Name Cancer Type
chr11:g.60096303T>A COSN10089999 C0052T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr11:g.60096997C>A COSN8686301 AOCS-081-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4713-5p ttgGGGAGAAaaagggaaa
 2
 UUCUCCCA m7a (m6a->m7a) -0.084000 -0.138000 -0.010000
hsa-miR-629-3p ttgGGGAGAAaaagggaaa
 0 GUUCUCCC m7b (m6b->m7b) no TS -0.076000 -1.510000


Mutation Mutation ID Sample Name Cancer Type
chr11:g.60097663A>G COSN5307768 RK085_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Mutation Mutation ID Sample Name Cancer Type
chr11:g.60098091T>A COSN1135316 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr11:g.60098102C>T COSN1135317 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1272 tatttTCATCATtgactac
 0 GAUGAUGA m7b Disrupted -0.214000 no TS 1.190000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
60096506 rs147720747 A A hsa-miR-302b-5p
hsa-miR-302d-5p
3
3
 TTAAAGAataaag
TTAAAGAataaag
 Disrupted
Disrupted
N
N
 0.044
0.047
G hsa-miR-362-5p
hsa-miR-500b-5p
hsa-miR-501-5p
2
2
2
 ttaAAGGATAaag
ttaAAGGATAaag
ttAAAGGATAaag
 Created
Created
Created
N
N
N
 -0.054
-0.054
-0.146

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