SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_052845
Gene Symbol: MMAB
Description: Homo sapiens methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.
Gene Location: chr12(-):109991520-110011358
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.109554285C>G COSN8694267 AOCS-168-1-8 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-128 cagcccgCACTGTGgaagg
 3
 UCACAGUG m7b Disrupted -0.057000 -0.044000 0.600000
hsa-miR-3681-3p cagcccgCACTGTGgaagg
 3
 ACACAGUG m7b Disrupted -0.026000 -0.041000 0.470000
hsa-miR-4734 cagCCCGCAGtgtggaagg
 0 GCUGCGGG m7b (m6c->m7b) no TS -0.218000 -4.700000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109554346A>C COSN5930006 RK190_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1207-3p tccagagaCCAGCTGgcag
 0 UCAGCUGG m7b Created no TS -0.113000 0.070000
hsa-miR-3663-5p tccagAGACCAGCtggcag
 2
 GCUGGUCU m8a Created -0.023000 -0.096000 -0.010000
hsa-miR-593-3p tcCAGAGACAagctggcag
 2
 UGUCUCUG m8a (m8a->m7b) -0.161000 -0.047000 0.140000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109554994G>A COSN8960111 SS6003111 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3155a ggtgtcacAGCCTGGatgt
 0 CCAGGCUC m7a Disrupted NA NA No effect
hsa-miR-3155b ggtgtcacAGCCTGGatgt
 0 CCAGGCUC m7a Disrupted NA NA No effect
hsa-miR-4645-5p ggtgtcacaGCCTGGatgt
 1
 ACCAGGCA m6b Disrupted -0.091000 -0.070000 No effect
hsa-miR-758 ggtGTCACAAcctggatgt
 1
 UUUGUGAC m7b (m6c->m7b) 0.013000 0.045000 No effect


Mutation Mutation ID Sample Name Cancer Type
chr12:g.109555694G>A COSN7309742 8015858 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr12:g.109555869T>A COSN4898211 CPCG_0099_Pr_P_F0 [prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4426 cggCCATCTTtcttgctgg
 0 GAAGAUGG m7b (m7b->m6c) 0.094000 no TS 3.270000
hsa-miR-4647 cggCCATCTTtcttgctgg
 0 GAAGAUGG m7b (m7b->m6c) 0.094000 no TS 6.720000
hsa-miR-4662a-3p cggccatCTATCTTgctgg
 0 AAAGAUAG m7b Created no TS 0.065000 -0.010000
hsa-miR-4662b cggCCATCTTTcttgctgg
 0 AAAGAUGG m8a Disrupted 0.094000 no TS 2.000000
hsa-miR-4426 cggCCATCTTtcttgctgg
 0 GAAGAUGG m7b (m7b->m6c) 0.094 no TS 3.27
hsa-miR-4647 cggCCATCTTtcttgctgg
 0 GAAGAUGG m7b (m7b->m6c) 0.094 no TS 6.72
hsa-miR-4662a-3p cggccatCTATCTTgctgg
 0 AAAGAUAG m7b Created no TS 0.065 -0.01
hsa-miR-4662b cggCCATCTTTcttgctgg
 0 AAAGAUGG m8a Disrupted 0.094 no TS 2

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109556261G>T COSN7309743 8035316 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-374a-3p tcagctTGATAAaatgagg
 0 CUUAUCAG m6b Created no TS 0.060000 -0.150000
hsa-miR-513c-5p tcagCTTGAGAAaatgagg
 1
 UUCUCAAG m8a Disrupted -0.077000 no TS 0.020000
hsa-miR-514b-5p tcagCTTGAGAAaatgagg
 1
 UUCUCAAG m8a Disrupted -0.087000 no TS 0.270000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109556543A>G COSN15465122 AOCS-171-1-0 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3117-5p gtgctttaAGTGTCacatt
 2
 AGACACUA m6b Created -0.219000 -0.326000 -0.240000
hsa-miR-489 gtgctttaaATGTCACatt
 0 GUGACAUC m7a (m7a->m6a) NA NA 0.030000
hsa-miR-3117-5p gtgctttaAGTGTCacatt
 2
 AGACACUA m6b Created -0.219000 -0.326000 -0.240000
hsa-miR-489 gtgctttaaATGTCACatt
 0 GUGACAUC m7a (m7a->m6a) NA NA 0.030000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109556564C>T COSN1141777 HX12T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-577 tgtgaTTTATCTgtgccaa
 0 UAGAUAAA m7b Created no TS -0.018000 -0.230000
hsa-miR-577 tgtgaTTTATCTgtgccaa
 0 UAGAUAAA m7b Created no TS -0.018 -0.23

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109556603A>G COSN5930007 RK199_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-186-3p cagaTTTGGGatgggacca
 3
 GCCCAAAG m6b Created 0.072000 0.049000 -1.950000
hsa-miR-4733-5p cagatTTGGGATgggacca
 0 AAUCCCAA m7b Created no TS -0.102000 -0.120000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.109556904C>A COSN1141778 HCC84T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1302 gcctttTGTCCCAgctcag
 10
 UUGGGACA m7b Disrupted -0.391000 -0.164000 No effect
hsa-miR-150-3p gcctttTGTACCAGctcag
 0 CUGGUACA m8a Created no TS -0.190000 No effect
hsa-miR-4298 gcctttTGTCCCAGctcag
 10
 CUGGGACA m8a Disrupted -0.382000 -0.164000 No effect
hsa-miR-1302 gcctttTGTCCCAgctcag
 0 UUGGGACA m7b Disrupted -0.391 -0.164 No effect
hsa-miR-150-3p gcctttTGTACCAGctcag
 0 CUGGUACA m8a Created no TS -0.19 No effect
hsa-miR-4298 gcctttTGTCCCAGctcag
 0 CUGGGACA m8a Disrupted -0.382 -0.164 No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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