| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_000242 |
|---|---|
| Gene Symbol: | MBL2 |
| Description: | Homo sapiens mannose-binding lectin (protein C) 2, soluble (MBL2), mRNA. |
| Gene Location: | chr10(-):54525139-54531460 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52765721A>G | COSN1492246 | RK075_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1279 |
agaCAATATGAtgaagtgc |
0 | UCAUAUUG | m8a | Created | no TS | -0.214000 |
-3.540000 |
|
| hsa-miR-4528 |
agacaaTATAATGAagtgc |
3 |
UCAUUAUA | m8a | Disrupted | -0.092000 | no TS |
0.060000 |
|
| hsa-miR-1279 |
agaCAATATGAtgaagtgc |
0 | UCAUAUUG | m8a | Created | no TS | -0.214 |
-3.54 |
|
| hsa-miR-4528 |
agacaaTATAATGAagtgc |
0 | UCAUUAUA | m8a | Disrupted | -0.092 | no TS |
0.06 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52765741A>T | COSN10069135 | C0035T | [kidney][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3144-3p |
atcAGGTATAgactcctga |
1 |
AUAUACCU | m7b | (m7b->m6c) | -0.138000 | no TS |
2.160000 |
|
| hsa-miR-4294 |
atcaggtatAGACTCCtga |
2 |
GGGAGUCU | m7b | (m7b->m6b) | -0.206000 | no TS |
0.010000 |
|
| hsa-miR-4796-5p |
atcaggTATAGACtcctga |
1 |
UGUCUAUA | m7b | Disrupted | -0.068000 | no TS |
2.460000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52766133G>T | COSN14535900 | 8068588 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1244 |
cttACTACTTaatctctaa |
0 | AAGUAGUU | m7a | (m6b->m7a) | NA | NA |
-0.800000 |
|
| hsa-miR-199a-3p |
cttACTACTGaatctctaa |
2 |
ACAGUAGU | m7b | (m7b->m6c) | -0.223000 | no TS |
1.780000 |
|
| hsa-miR-199b-3p |
cttACTACTGaatctctaa |
2 |
ACAGUAGU | m7b | (m7b->m6c) | -0.223000 | no TS |
1.780000 |
|
| hsa-miR-222-5p |
cttaCTACTGAatctctaa |
1 |
CUCAGUAG | m7b | Disrupted | -0.208000 | no TS |
6.310000 |
|
| hsa-miR-3129-5p |
cttACTACTGaatctctaa |
2 |
GCAGUAGU | m7b | (m7b->m6c) | -0.213000 | no TS |
0.910000 |
|
| hsa-miR-562 |
cttaCTACTTaatctctaa |
0 | AAAGUAGC | m6b | Created | no TS | -0.040000 |
-4.920000 |
|
| hsa-miR-936 |
cttaCTACTGaatctctaa |
2 |
ACAGUAGA | m6b | Disrupted | -0.150000 | -0.079000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52766186G>T | 9_117488 | CRC-9-Tumor | Colorectal adenocarcinoma | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-3691-3p |
gtttctACTTGGaccacat |
1 |
ACCAAGUC | m6b | Created | no TS | -0.046 |
-4.37 |
|
| hsa-miR-5697 |
gtttCTACTTGgaccacat |
0 | UCAAGUAG | m7b | Created | no TS | -0.083 |
-0.71 |
|
| hsa-miR-936 |
gttTCTACTGggaccacat |
0 | ACAGUAGA | m7b | (m7b->m6c) | -0.149 | -0.071 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52766256A>G | COSN1492247 | RK042_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-192-5p |
tcttcttaAGGTCAagatt |
0 | CUGACCUA | m6b | Created | no TS | -0.103000 |
-6.780000 |
|
| hsa-miR-215 |
tcttcttaAGGTCAagatt |
0 | AUGACCUA | m6b | Created | no TS | -0.103000 |
-6.700000 |
|
| hsa-miR-3658 |
tcTTCTTAAAgtcaagatt |
1 |
UUUAAGAA | m8a | (m8a->m7b) | -0.037000 | -0.034000 |
0.050000 |
|
| hsa-miR-192-5p |
tcttcttaAGGTCAagatt |
0 | CUGACCUA | m6b | Created | no TS | -0.103000 |
-6.780000 |
|
| hsa-miR-215 |
tcttcttaAGGTCAagatt |
0 | AUGACCUA | m6b | Created | no TS | -0.103000 |
-6.700000 |
|
| hsa-miR-3658 |
tcTTCTTAAAgtcaagatt |
1 |
UUUAAGAA | m8a | (m8a->m7b) | -0.037000 | -0.034000 |
0.050000 |
|
| hsa-miR-192-5p |
tcttcttaAGGTCAagatt |
0 | CUGACCUA | m6b | Created | no TS | -0.103 |
-6.78 |
|
| hsa-miR-215 |
tcttcttaAGGTCAagatt |
0 | AUGACCUA | m6b | Created | no TS | -0.103 |
-6.7 |
|
| hsa-miR-3658 |
tcTTCTTAAAgtcaagatt |
0 | UUUAAGAA | m8a | (m8a->m7b) | -0.037 | -0.034 |
0.05 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52766294T>G | COSN5876704 | RK122_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1284 |
attgtacaTGTATAGttgt |
1 |
UCUAUACA | m7b | Created | -0.172000 | -0.249000 | No effect | |
| hsa-miR-4666a-5p |
attgtACATGTATagttgt |
2 |
AUACAUGU | m8a | Created | -0.108000 | -0.194000 |
-0.030000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52766603C>G | COSN6973399 | 8030032 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-105-3p |
tgccCATCCGaaaatcata |
0 | ACGGAUGU | m6b | Created | no TS | -0.147000 |
-7.760000 |
|
| hsa-miR-1193 |
tgcCCATCCCaaaatcata |
0 | GGGAUGGU | m7a | (m7a->m6b) | NA | NA |
0.110000 |
|
| hsa-miR-3122 |
tgcccaTCCCAAaatcata |
2 |
GUUGGGAC | m6b | Disrupted | -0.012000 | no TS |
1.580000 |
|
| hsa-miR-3913-5p |
tgcccaTCCCAAAatcata |
2 |
UUUGGGAC | m7a | Disrupted | -0.012000 | no TS |
3.570000 |
|
| hsa-miR-450b-3p |
tgcccATCCCAAaatcata |
2 |
UUGGGAUC | m7a | Disrupted | -0.054000 | no TS |
3.950000 |
|
| hsa-miR-5089 |
tgcccATCCCAaaatcata |
2 |
GUGGGAUU | m6b | Disrupted | -0.018000 | no TS |
4.190000 |
|
| hsa-miR-5187-5p |
tgccCATCCCAaaatcata |
2 |
UGGGAUGA | m7a | Disrupted | -0.074000 | no TS |
0.120000 |
|
| hsa-miR-769-3p |
tgcccATCCCAaaatcata |
2 |
CUGGGAUC | m6b | Disrupted | -0.054000 | no TS |
1.160000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52767437G>A | COSN8186358 | PCSI_0083_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4318 |
gactgCACAGTaatttcgt |
1 |
CACUGUGG | m6b | Disrupted | -0.662000 | -0.574000 |
0.010000 |
|
| hsa-miR-4693-5p |
gactgCACAGTAatttcgt |
1 |
AUACUGUG | m7b | Disrupted | -0.298000 | -0.111000 |
0.630000 |
|
| hsa-miR-892a |
gactgCACAGTaatttcgt |
1 |
CACUGUGU | m6b | Disrupted | -0.383000 | -0.303000 | No effect | |
| hsa-miR-944 |
gactgcacAATAATTTcgt |
0 | AAAUUAUU | m8a | Created | no TS | 0.120000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52767629A>G | COSN1492248 | RK019_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-302c-5p |
taatgagATGTTAAAccat |
0 | UUUAACAU | m8a | Created | no TS | -0.015000 | No effect | |
| hsa-miR-3143 |
taatgagATGTTAaaccat |
0 | AUAACAUU | m6b | Created | no TS | 0.001000 | No effect | |
| hsa-miR-889 |
taatgaGATATTAAaccat |
2 |
UUAAUAUC | m8a | Disrupted | -0.120000 | -0.033000 |
0.070000 |
|
| hsa-miR-302c-5p |
taatgagATGTTAAAccat |
0 | UUUAACAU | m8a | Created | no TS | -0.015000 | No effect | |
| hsa-miR-3143 |
taatgagATGTTAaaccat |
0 | AUAACAUU | m6b | Created | no TS | 0.001000 | No effect | |
| hsa-miR-889 |
taatgaGATATTAAaccat |
2 |
UUAAUAUC | m8a | Disrupted | -0.120000 | -0.033000 |
0.070000 |
|
| hsa-miR-302c-5p |
taatgagATGTTAAAccat |
0 | UUUAACAU | m8a | Created | no TS | -0.015 | No effect | |
| hsa-miR-3143 |
taatgagATGTTAaaccat |
0 | AUAACAUU | m6b | Created | no TS | 0.001 | No effect | |
| hsa-miR-889 |
taatgaGATATTAAaccat |
0 | UUAAUAUC | m8a | Disrupted | -0.12 | -0.033 |
0.07 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr10:g.52767775T>G | COSN8711972 | AOCS-094-6-X | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-421 |
cctgtgctCTGTTGAgcct |
2 |
AUCAACAG | m7b | Disrupted | -0.024000 | 0.027000 |
-0.040000 |
|
| hsa-miR-4709-5p |
cctgtgctCTGTTGagcct |
2 |
ACAACAGU | m6b | Disrupted | -0.028000 | no TS |
0.010000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr10:g.52767940->T | ICGC_ssm_v3_22004 | BN50T | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-3908 |
tagtagtCATTGCTaattat |
0 | GAGCAAUG | m7b | Created | -0.141000 | -0.511000 |
-0.020000 |
| hsa-miR-3942-5p |
tagtagtcATTGCTaattat |
0 | AAGCAAUA | m6b | Created | -0.134000 | -0.259000 | No effect |
| hsa-miR-4766-3p |
tagtagtcATTGCTAattat |
0 | AUAGCAAU | m7b | Created | -0.263000 | -0.541000 |
-0.030000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 52766097 | rs2099903 | T | G |
hsa-miR-4666a-5p hsa-miR-8060 |
4 4 |
cttCATGTAActa CTTCATGtaacta |
Created Created |
N N |
-0.016 -0.055 |
| T |
hsa-miR-1252-3p hsa-miR-3646 |
5 4 |
ctTCATTTAacta cTTCATTTAacta |
Disrupted Disrupted |
N N |
0.057 0.088 |
|||
| 52766258 | rs2120131 | C | A |
hsa-miR-3653 hsa-miR-3658 |
0 |
CTTCTTAAagtca cTTCTTAAAgtca |
Created Created |
N N |
-0.064 0.07 |
| C |
hsa-miR-3185 hsa-miR-4635 hsa-miR-4709-3p |
0 |
CTTCTTCAagtca cttCTTCAAGtca ctTCTTCAAgtca |
Disrupted Disrupted Disrupted |
N N N |
-0.096 -0.118 -0.002 |
|||
| 52766600 | rs192591672 | A | A |
hsa-miR-3122 hsa-miR-3913-5p hsa-miR-450a-1-3p hsa-miR-6513-5p hsa-miR-887-5p |
2 2 2 2 2 |
TCCCAAAatcata TCCCAAAatcata TCCCAAAatcata TCCCAAAatcata TCCCAAAatcata |
Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N |
-0.012 -0.012 -0.003 -0.007 0.003 |
| T |
hsa-miR-3145-3p |
3 |
tcccAATATCAta |
Created |
N |
0.083 |
|||
| 52766602 | rs182107601 | A | A |
hsa-miR-3122 hsa-miR-3913-5p hsa-miR-450a-1-3p hsa-miR-450b-3p hsa-miR-5089-5p hsa-miR-5187-5p hsa-miR-6513-5p hsa-miR-6728-5p hsa-miR-769-3p hsa-miR-887-5p |
2 2 2 2 2 2 2 2 2 2 |
caTCCCAAAatca caTCCCAAAatca caTCCCAAAatca cATCCCAAaatca cATCCCAAaatca CATCCCAaaatca cATCCCAAAatca CATCCCAAaatca cATCCCAAaatca caTCCCAAAatca |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N |
-0.012 -0.012 -0.003 -0.054 -0.018 -0.074 -0.023 -0.11 -0.054 0.003 |
| C |
hsa-miR-2110 hsa-miR-3150a-3p hsa-miR-4260 hsa-miR-4450 hsa-miR-450a-2-3p hsa-miR-5572 hsa-miR-6763-5p hsa-miR-6810-5p hsa-miR-6857-5p |
2 2 2 2 2 2 2 2 2 |
caTCCCCAAatca caTCCCCAAatca catCCCCAAAtca cATCCCCAaatca caTCCCCAAAtca catCCCCAAAtca caTCCCCAAatca caTCCCCAAatca cATCCCCAAatca |
Created Created Created Created Created Created Created Created Created |
N N N N N N N N N |
-0.061 -0.049 -0.06 -0.092 -0.145 -0.063 -0.059 -0.067 -0.121 |