SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_016586
Gene Symbol:	MBIP
Description:	Homo sapiens MAP3K12 binding inhibitory protein 1 (MBIP), transcript variant 2, mRNA.
Gene Location:	chr14(-):36767763-36789882
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.36298810G>A			COSN8588599		44_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3171	caagtgctgATACATCTtt	0	AGAUGUAU	m8a	(m7a->m8a)	no TS	-0.171000	0.330000
hsa-miR-634	caagTGCTGGTacatcttt	1	AACCAGCA	m7b	Disrupted	-0.400000	no TS	4.830000

Mutation			Mutation ID		Sample Name		Cancer Type
chr14:g.36299071C>T			COSN8864804		SNUH_G16_S1		[haematopoietic_and_lymphoid_tissue][NS][haematopoietic_neoplasm][acute_myeloid_leukaemia]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1255a	aactcctCTCATCCTtgtc	3	AGGAUGAG	m8a	Disrupted	0.000000	no TS	No effect
hsa-miR-1255b-5p	aactcctCTCATCCttgtc	3	CGGAUGAG	m7b	Disrupted	0.000000	no TS	No effect
hsa-miR-3916	aacTCCTCTTatccttgtc	0	AAGAGGAA	m7a	(m6b->m7a)	NA	NA	No effect
hsa-miR-4712-3p	aactcCTCTCATccttgtc	5	AAUGAGAG	m7b	Disrupted	0.000000	no TS	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
36299070	rs4900833	A	A	hsa-miR-1255a hsa-miR-1255b-5p hsa-miR-4712-3p	3 3 5	cctCTCATCCttg cctCTCATCCttg cCTCTCATccttg	Disrupted Disrupted Disrupted	N N N	No Change No Change No Change

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