SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_001134745
Gene Symbol: LRRTM4
Description: Homo sapiens leucine rich repeat transmembrane neuronal 4 (LRRTM4), transcript variant 1, mRNA.
Gene Location: chr2(-):76974849-77749502
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr2:g.76747918G>A COSN7993366 ASHPC_0017_Pa_P [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1270 aagATCTCCAaatgagaag
 0 CUGGAGAU m7b (m6c->m7b) no TS -0.277000 -0.590000
hsa-miR-1298 aagatctcCGAATGAgaag
 5
 UUCAUUCG m7b Disrupted -0.182000 -0.084000 -0.490000
hsa-miR-4531 aagaTCTCCAaatgagaag
 0 AUGGAGAA m6b Created no TS -0.116000 -4.550000
hsa-miR-4683 aaGATCTCCAaatgagaag
 0 UGGAGAUC m8a (m7b->m8a) -0.259000 -0.449000 0.020000
hsa-miR-5091 aagaTCTCCGaatgagaag
 0 ACGGAGAC m6b Disrupted -0.220000 no TS 5.040000
hsa-miR-5696 aagatctccAAATGAGaag
 0 CUCAUUUA m7a (m6a->m7a) NA NA -0.230000
hsa-miR-579 aagatctcCAAATGAgaag
 0 UUCAUUUG m7b Created no TS 0.002000 -0.030000
hsa-miR-620 aagATCTCCAaatgagaag
 0 AUGGAGAU m7b (m6c->m7b) no TS -0.287000 -0.590000
hsa-miR-644b-3p aagatctcCAAATGAgaag
 0 UUCAUUUG m7b Created no TS -0.007000 -0.010000


Mutation Mutation ID Sample Name Cancer Type
chr2:g.76747976T>A COSN7993367 PCSI_0303_Pa_P_526 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr2:g.76748039A>G COSN8895206 SS6003149 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-499b-5p aacccaatAAGTCTGggtg
 0 ACAGACUU m7b Disrupted -0.141000 no TS 0.360000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.76748113A>G COSN15095351 LP6005409-DNA_E02 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3121-5p tgtacCAAAGGAaaatgtg
 0 UCCUUUGC m7a Created no TS -0.089000 6.020000
hsa-miR-9-5p tgtACCAAAGgaaaatgtg
 0 UCUUUGGU m7b (m6c->m7b) no TS -0.157000 -0.040000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.76748445G>A COSN5957138 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-3p aatgcTCCCAGatgtaaat
 0 GCUGGGAA m6b Created no TS -0.163000 -5.440000
hsa-miR-30b-3p aatgCTCCCAGatgtaaat
 0 CUGGGAGG m7a Created NA NA -4.330000
hsa-miR-30c-1-3p aatgCTCCCAGatgtaaat
 0 CUGGGAGA m7a Created NA NA -7.350000
hsa-miR-30c-2-3p aatgCTCCCAGatgtaaat
 0 CUGGGAGA m7a Created NA NA -0.360000
hsa-miR-3192 aatgCTCCCAGAtgtaaat
 0 UCUGGGAG m8a Created no TS -0.394000 -1.800000
hsa-miR-3689a-3p aatgCTCCCAGatgtaaat
 0 CUGGGAGG m7a Created NA NA -0.030000
hsa-miR-3689b-3p aatgCTCCCAGatgtaaat
 0 CUGGGAGG m7a Created NA NA -1.100000
hsa-miR-3689c aatgCTCCCAGatgtaaat
 0 CUGGGAGG m7a Created NA NA -1.100000
hsa-miR-4314 aatgcTCCCAGAtgtaaat
 0 CUCUGGGA m7b Created no TS -0.192000 -1.560000
hsa-miR-4497 aatgcTCCCGGAtgtaaat
 4
 CUCCGGGA m7b Disrupted -0.320000 no TS 5.790000
hsa-miR-4646-5p aatgcTCCCAGatgtaaat
 0 ACUGGGAA m6b Created no TS -0.163000 -0.630000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.76748610G>A COSN7084235 8068564 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-147b cacaatCGCACAatcgagc
 0 GUGUGCGG m6b Created no TS -0.229000 -4.570000
hsa-miR-210 cacaatCGCACAatcgagc
 0 CUGUGCGU m6b Created no TS -0.228000 -11.700000

Mutation Mutation ID Sample Name Cancer Type
chr2:g.76748630G>T 0_95 Small cell lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-362-5p cttaAAGGATaatgggtgt
 12
 AAUCCUUG m6b Created no TS -0.094 -2.79
hsa-miR-4279 cttaaAGGAGAatgggtgt
 16
 CUCUCCUC m6b Disrupted -0.089 no TS 4.32
hsa-miR-500b cttaAAGGATaatgggtgt
 12
 AAUCCUUG m6b Created no TS -0.091 -1.5
hsa-miR-501-5p cttAAAGGATaatgggtgt
 11
 AAUCCUUU m7b (m6c->m7b) no TS -0.254 -7.76

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
76748033 rs148868335 G G hsa-miR-1295b-5p
hsa-miR-1912
hsa-miR-500b-3p
hsa-miR-6802-3p
3
3
4
4
 agTCTGGGTgaat
agTCTGGGTgaat
agtCTGGGTGAat
agtctGGGTGAAt
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.196
-0.187
-0.406
-0.16
A hsa-miR-4494
hsa-miR-499b-5p
hsa-miR-6794-3p
2
2
4
 AGTCTGAgtgaat
AGTCTGAgtgaat
agtctGAGTGAAt
 Created
Created
Created
N
N
N
 -0.106
-0.14
-0.094

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