SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_020873
Gene Symbol:	LRRN1
Description:	Homo sapiens leucine rich repeat neuronal 1 (LRRN1), mRNA.
Gene Location:	chr3(+):3841120-3889387
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.3847395T>G			COSN6426752		HX13T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3065-5p	tttttttttTTTGTTGtaa	17	UCAACAAA	m7b	(m7b->m6c)	-0.246000	-0.230000	1.370000
hsa-miR-3529-3p	tttttttTTGTTGTTgtaa	16	AACAACAA	m8a	Created	-0.564000	-0.668000	1.390000
hsa-miR-3613-3p	ttttttTTTTTTGTtgtaa	0	ACAAAAAA	m8a	Disrupted	-0.022000	-0.030000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr3:g.3847636A>G			COSN15291136		0089_CRUK_PC_0089_T1_DNA		[prostate][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-425-5p	caataatGTGTCATTtata	0	AAUGACAC	m8a	Created	no TS	-0.267000	-2.250000
hsa-miR-4643	caataATGTGTCatttata	0	GACACAUG	m7a	Created	NA	NA	1.040000
hsa-miR-642a-3p	caataATGTGTCatttata	0	AGACACAU	m7b	Created	no TS	-0.411000	-6.290000
hsa-miR-642b-3p	caataATGTGTCatttata	0	AGACACAU	m7b	Created	no TS	-0.411000	-6.280000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
3847330	rs116619315	G	G	hsa-miR-3529-3p	18	aaTGTTGTAtcaa	Disrupted	N	-0.061
			T	hsa-miR-3161	19	aatgttTTATCAA	Created	N	-0.037
3847395	rs200876834	T	T	hsa-miR-3065-5p hsa-miR-3613-3p	5 4	ttttttTTTGTTG tttTTTTTTGttg	Disrupted Disrupted	N N	-0.016 0.008
			G	hsa-miR-3529-3p	5	ttttTTGTTGTtg	Created	N	-0.104

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