SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_020737
Gene Symbol:	LRFN2
Description:	Homo sapiens leucine rich repeat and fibronectin type III domain containing 2 (LRFN2), mRNA.
Gene Location:	chr6(-):40359372-40555126
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.40391650G>T			4_1279		UNP452198		Acute myeloid leukemia
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.40391861C>G			COSN1332894		HCC109T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3688-3p	gtggagTTTCCATggtgat	14	UAUGGAAA	m7b	Disrupted	-0.050000	no TS	8.890000
hsa-miR-4261	gtggaGTTTCCatggtgat	14	AGGAAACA	m6b	Disrupted	-0.075000	no TS	0.410000
hsa-miR-3688-3p	gtggagTTTCCATggtgat	14	UAUGGAAA	m7b	Disrupted	-0.050000	no TS	8.890000
hsa-miR-4261	gtggaGTTTCCatggtgat	14	AGGAAACA	m6b	Disrupted	-0.075000	no TS	0.410000
hsa-miR-3688-3p	gtggagTTTCCATggtgat	0	UAUGGAAA	m7b	Disrupted	-0.05	no TS	8.89
hsa-miR-4261	gtggaGTTTCCatggtgat	0	AGGAAACA	m6b	Disrupted	-0.075	no TS	0.41

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
40391860	rs147572837	C	C	hsa-miR-3688-3p hsa-miR-4261 hsa-miR-7153-3p	14 14 14	agTTTCCATggtg aGTTTCCAtggtg agtttCCATGGTg	Disrupted Disrupted Disrupted	N N N	-0.05 -0.075 -0.245
40391862	rs140292085	T	T	hsa-miR-3688-3p hsa-miR-4261	14 14	ggagTTTCCATgg ggaGTTTCCAtgg	Disrupted Disrupted	N N	-0.05 -0.075
			G	hsa-miR-196a-3p	14	ggaGTTGCCAtgg	Created	N	-0.147

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