SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001198689 |
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Gene Symbol: | LEPR |
Description: | Homo sapiens leptin receptor (LEPR), transcript variant 3, mRNA. |
Gene Location: | chr1(+):65991371-66101111 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65633330C>A | COSN6464354 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-148a-5p |
gatttAGAACTTaaaatag |
6 |
AAAGUUCU | m7b | Disrupted | -0.342000 | -0.013000 |
0.460000 |
|
hsa-miR-148b-5p |
gatttAGAACTTaaaatag |
2 |
AAGUUCUG | m7a | Disrupted | -0.089000 | -0.089000 |
0.010000 |
|
hsa-miR-3168 |
gattTAGAACTtaaaatag |
7 |
GAGUUCUA | m7b | Disrupted | -0.243000 | no TS |
0.630000 |
|
hsa-miR-4775 |
gatttagAAATTAAaatag |
1 |
UUAAUUUU | m7a | Created | 0.055000 | 0.084000 |
-0.030000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65633492T>G | 9_10816 | CRC-3-Tumor | Colorectal adenocarcinoma | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-1226-3p |
ttatgGCTGGTGctgtcat |
17 |
UCACCAGC | m7b | Created | no TS | -0.244 |
-5.62 |
|
hsa-miR-29a-3p |
ttatggcTGGTGCTgtcat |
16 |
UAGCACCA | m7b | Created | no TS | -0.208 |
-3.67 |
|
hsa-miR-29b-3p |
ttatggcTGGTGCTgtcat |
16 |
UAGCACCA | m7b | Created | no TS | -0.208 |
-3.672 |
|
hsa-miR-29c-3p |
ttatggcTGGTGCTgtcat |
16 |
UAGCACCA | m7b | Created | no TS | -0.208 |
-3.48 |
|
hsa-miR-3065-3p |
ttatggctGGTGCTGtcat |
12 |
UCAGCACC | m7b | Created | no TS | -0.278 |
-5.04 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65633614G>T | COSN6041606 | RK191_C01 | [liver][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-145-3p |
ataagtatGGAATCagtga |
0 | GGAUUCCU | m6b | Disrupted | -0.134000 | no TS |
0.710000 |
|
hsa-miR-3920 |
ataagtatgTAATCAGTga |
0 | ACUGAUUA | m8a | (m7b->m8a) | no TS | -0.142000 |
-0.450000 |
|
hsa-miR-587 |
ataagTATGGAAtcagtga |
1 |
UUUCCAUA | m7b | Disrupted | -0.266000 | -0.157000 |
1.910000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65633655T>G | COSN8913963 | SS6003121 | [oesophagus][NS][carcinoma][adenocarcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-4261 |
tgtccaaacGTTTCCattt |
0 | AGGAAACA | m6b | Created | no TS | -0.097000 |
-0.140000 |
|
hsa-miR-561-3p |
tgtccAAACTTTtccattt |
1 |
CAAAGUUU | m7b | Disrupted | 0.029000 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65633755C>G | COSN6464355 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-10b-3p |
aactttgttGAATCTGgga |
3 |
ACAGAUUC | m7b | (m6c->m7b) | -0.103000 | -0.238000 |
-3.000000 |
|
hsa-miR-3065-5p |
aacTTTGTTGAatctggga |
0 | UCAACAAA | m8a | Created | no TS | -0.079000 |
-2.820000 |
|
hsa-miR-421 |
aacttTGTTGAatctggga |
0 | AUCAACAG | m6b | Created | no TS | -0.040000 |
-0.880000 |
|
hsa-miR-4272 |
aactttGTTGAATctggga |
0 | CAUUCAAC | m7b | Created | 0.030000 | -0.052000 |
-1.190000 |
|
hsa-miR-7-1-3p |
aacTTTGTTGaatctggga |
1 |
CAACAAAU | m7a | (m6a->m7a) | -0.047000 | -0.047000 |
0.040000 |
|
hsa-miR-7-2-3p |
aacTTTGTTGaatctggga |
1 |
CAACAAAU | m7a | (m6a->m7a) | -0.056000 | -0.056000 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65634137G>A | COSN8143069 | PCSI_0312_Pa_P_526 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-147a |
tcagCACACAaattatgct |
0 | GUGUGUGG | m6b | Created | no TS | -0.052000 | No effect | |
hsa-miR-5010-3p |
tcagcACACAAAttatgct |
0 | UUUUGUGU | m7b | Created | no TS | -0.000000 |
-0.280000 |
|
hsa-miR-599 |
tcagcACACAAattatgct |
0 | GUUGUGUC | m6b | Created | no TS | 0.001000 |
-0.070000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr1:g.65634148C>T | COSN6464356 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-103a-3p |
attATGCTGCgttgctcac |
0 | AGCAGCAU | m7b | (m7b->m6b) | -0.105000 | no TS |
0.170000 |
|
hsa-miR-107 |
attATGCTGCgttgctcac |
0 | AGCAGCAU | m7b | (m7b->m6b) | -0.105000 | no TS |
0.240000 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr1:g.65634767G>A | COSN6464357 | CHC205T | [liver][NS][carcinoma][hepatocellular_carcinoma] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
65633330 | rs17415296 | C | C |
hsa-miR-148a-5p hsa-miR-3168 hsa-miR-7856-5p |
6 7 13 |
ttAGAACTTAaaa tTAGAACTtaaaa ttagaaCTTAAAA |
Disrupted Disrupted Disrupted |
N N N |
-0.329 -0.243 -0.012 |
A |
hsa-miR-4263 hsa-miR-4775 hsa-miR-576-5p |
7 7 7 |
TTAGAAAttaaaa ttagAAATTAAaa TTAGAAAttaaaa |
Created Created Created |
N N N |
-0.041 0.029 -0.05 |
|||
65633755 | rs3206172 | C | |||||||
G |
hsa-miR-10b-3p hsa-miR-3065-5p hsa-miR-421 hsa-miR-4272 hsa-miR-7159-5p |
5 1 0 0 0 |
tttgttGAATCTG TTTGTTGAatctg ttTGTTGAAtctg tttGTTGAATctg tTTGTTGAAtctg |
Created Created Created Created Created |
N N N N N |
-0.135 -0.079 -0.04 -0.082 -0.16 |
|||
65634082 | rs146805288 | C | C |
hsa-miR-148b-5p hsa-miR-3909 hsa-miR-4743-3p hsa-miR-6852-3p hsa-miR-6874-3p hsa-miR-6888-3p |
2 7 3 7 2 3 |
tgaggaCAGAACT tGAGGACAgaact tgagGACAGAAct tGAGGACAgaact tgaggaCAGAACT tgagGACAGAAct |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N |
-0.089 -0.077 -0.014 -0.074 -0.07 -0.032 |
T |
hsa-miR-3168 |
2 |
tgaggaTAGAACT |
Created |
N |
-0.062 |
|||
65634148 | rs12034502 | T | C |
hsa-miR-103a-3p hsa-miR-107 |
0 |
ATGCTGCgttgct ATGCTGCgttgct |
Created Created |
N N |
-0.105 -0.105 |