SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_173464
Gene Symbol:	L3MBTL4
Description:	Homo sapiens l(3)mbt-like 4 (Drosophila) (L3MBTL4), mRNA.
Gene Location:	chr18(-):5954704-6414910
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr18:g.5954886G>T			COSN6130089		RK308_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-142-5p	atttCTTTATatctttacc	0	CAUAAAGU	m6b	Created	no TS	-0.030000	No effect
hsa-miR-3156-5p	atttctttAGATCTTTacc	1	AAAGAUCU	m8a	Disrupted	-0.222000	no TS	3.230000
hsa-miR-340-5p	atttCTTTATAtctttacc	0	UUAUAAAG	m7b	Created	no TS	-0.115000	-0.780000
hsa-miR-4509	atttCTTTAGatctttacc	6	ACUAAAGG	m6b	Disrupted	-0.086000	no TS	0.260000
hsa-miR-4662a-3p	atttctttaTATCTTTacc	0	AAAGAUAG	m7a	(m6a->m7a)	NA	NA	-0.010000
hsa-miR-4744	attTCTTTAGAtctttacc	6	UCUAAAGA	m8a	Disrupted	-0.292000	no TS	0.410000
hsa-miR-5590-3p	atttCTTTATatctttacc	0	AAUAAAGU	m6b	Created	no TS	-0.040000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr18:g.5955719A>G			COSN8550786		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1285-5p	tcatGTGAGATttttgtgt	7	GAUCUCAC	m7b	Disrupted	-0.178000	no TS	3.580000
hsa-miR-216a	tcatgTGAGATTtttgtgt	9	UAAUCUCA	m7b	Disrupted	-0.088000	no TS	3.900000
hsa-miR-548ac	tcatgtgaGGTTTTTGtgt	3	CAAAAACC	m8a	Created	0.070000	0.062000	-1.510000
hsa-miR-548c-3p	tcatgtgaGATTTTTGtgt	8	CAAAAAUC	m8a	Disrupted	0.072000	no TS	2.800000
hsa-miR-548d-3p	tcatgtgaGGTTTTTGtgt	3	CAAAAACC	m8a	Created	0.080000	0.062000	-3.380000
hsa-miR-548h-3p	tcatgtgaGGTTTTTGtgt	3	CAAAAACC	m8a	Created	0.070000	0.071000	-2.460000
hsa-miR-548z	tcatgtgaGGTTTTTGtgt	3	CAAAAACC	m8a	Created	0.070000	0.071000	-2.460000

Mutation			Mutation ID		Sample Name		Cancer Type
chr18:g.5956030T>G			COSN14638908		PCSI_0072_Pa_P_526		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
5955814	rs183420581	T	T	hsa-miR-4490 hsa-miR-548ac hsa-miR-548ae hsa-miR-548ah-3p hsa-miR-548aj-3p hsa-miR-548am-3p hsa-miR-548aq-3p hsa-miR-548d-3p hsa-miR-548h-3p hsa-miR-548j-3p hsa-miR-548x-3p hsa-miR-548z	2 3 3 3 3 3 3 3 3 3 3 3	atgtttTTACCAG atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag atGTTTTTAccag	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N N N N	-0.179 0.07 0.073 0.076 0.073 0.076 0.073 0.08 0.07 0.073 0.073 0.07
			C	hsa-miR-3529-5p hsa-miR-379-5p hsa-miR-4451 hsa-miR-4650-3p hsa-miR-494-3p	2 2 2 2 6	atgttTCTACCAg atgttTCTACCAg atgttTCTACCAg atgtTTCTACCAg ATGTTTCtaccag	Created Created Created Created Created	N N N N N	-0.127 -0.13 -0.111 -0.245 -0.082

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