SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001648
Gene Symbol:	KLK3
Description:	Homo sapiens kallikrein-related peptidase 3 (KLK3), transcript variant 3, mRNA.
Gene Location:	chr19(+):51358170-51364020
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50860373A>T			COSN5761580		HX19T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4302	tgaggACACTGataggatg	2	CCAGUGUG	m6b	Created	-0.206000	-0.303000	1.220000
hsa-miR-5094	tgaggaCACTGATaggatg	0	AAUCAGUG	m7b	Created	no TS	-0.263000	-4.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50860508A>C			0_562				Prostate cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3180	gcacaaCGCCCCAgacact	4	UGGGGCGG	m7a	Created	no TS	-0.229	-12.13
hsa-miR-3180-3p	gcacaaCGCCCCAgacact	4	UGGGGCGG	m7a	Created	no TS	-0.229	-13.73
hsa-miR-3196	gcacaaCGCCCCagacact	4	CGGGGCGG	m6b	Created	no TS	-0.236	-0.03
hsa-miR-4299	gcacaacgCACCAGacact	4	GCUGGUGA	m6b	Disrupted	-0.099	no TS	1.71
hsa-miR-4456	gcacaacgCACCAGacact	4	CCUGGUGG	m6b	Disrupted	-0.1	no TS	7.11
hsa-miR-4466	gcacaaCGCACCagacact	4	GGGUGCGG	m6b	Disrupted	-0.206	no TS	9.41
hsa-miR-4667-5p	gcacaacgCCCCAGacact	4	ACUGGGGA	m6b	Created	-0.188	-0.306	No effect
hsa-miR-4700-5p	gcacaacgCCCCAGAcact	4	UCUGGGGA	m7a	Created	-0.188	-0.313	-1.43
hsa-miR-548q	gcacaacGCACCAGacact	4	GCUGGUGC	m7b	Disrupted	-0.341	no TS	7.01
hsa-miR-637	gcacaacgCCCCAGacact	4	ACUGGGGG	m6b	Created	no TS	-0.126	-3.53
hsa-miR-675-5p	gcacaaCGCACCAgacact	4	UGGUGCGG	m7a	Disrupted	-0.213	no TS	3.38

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
50860433	rs16987775	A	A	hsa-miR-3691-5p hsa-miR-376b-5p hsa-miR-376c-5p hsa-miR-3911 hsa-miR-4302 hsa-miR-4752 hsa-miR-6733-3p hsa-miR-8056	1 1 1 2 2 1 2 1	ggATCCACActga ggATCCACActga ggATCCACActga ggaTCCACACtga ggatcCACACTGA ggATCCACActga ggatccACACTGA ggATCCACActga	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N	-0.076 -0.09 -0.09 -0.137 -0.206 -0.048 -0.061 -0.071
			C	hsa-miR-1296-3p hsa-miR-194-3p hsa-miR-4450 hsa-miR-4713-3p hsa-miR-491-5p hsa-miR-5693 hsa-miR-6857-5p	2 2 1 1 2 2 1	ggatCCCCACTga ggatcCCCACTGA ggATCCCCActga GGATCCCcactga ggaTCCCCACtga ggatccCCACTGA ggATCCCCActga	Created Created Created Created Created Created Created	N N N N N N N	-0.23 -0.283 -0.11 -0.16 -0.174 -0.074 -0.086
50860509	rs1803136	C	C	hsa-miR-1231 hsa-miR-4299 hsa-miR-4456 hsa-miR-4466 hsa-miR-548q hsa-miR-675-5p hsa-miR-7978	3 3 3 2 4 2 4	aacgcaCCAGACA aacgCACCAGAca aacgCACCAGAca aaCGCACCAgaca aacGCACCAGAca aaCGCACCAgaca aacgCACCAGAca	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N	-0.142 -0.1 -0.101 -0.206 -0.342 -0.213 -0.116
			T	hsa-miR-4502	4	aacgCATCAGAca	Created	N	-0.071

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