SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
	Home	Search	Help	Download

Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001030047
Gene Symbol:	KLK3
Description:	Homo sapiens kallikrein-related peptidase 3 (KLK3), transcript variant 3, mRNA.
Gene Location:	chr19(+):51358170-51364020
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50859651G>T			COSN6146275		RK195_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3680-5p	ctctGTGAGTagccacggg	0	GACUCACU	m6b	Created	no TS	-0.102000	-0.030000
hsa-miR-4268	ctctgtGAGGAGCCacggg	0	GGCUCCUC	m8a	Disrupted	-0.213000	no TS	0.280000
hsa-miR-4448	ctctgtgAGGAGCCacggg	0	GGCUCCUU	m7a	Disrupted	NA	NA	0.010000
hsa-miR-4798-3p	ctctGTGAGTagccacggg	0	AACUCACG	m6b	Created	no TS	-0.135000	-1.630000

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50859943T>G			COSN8974981		AOCS-147-1-1		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50859986C>A			ICGC_e37a8552-a475-4ffe-82f8-12a0d9e4d533		PCSI_0017_Pa_P		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-296-5p	ttctgGGGGCCCacttgtc	0	AGGGCCCC	m7b	Disrupted	-0.519	no TS	8.17
hsa-miR-3545-5p	ttctggggGACCACTtgtc	0	UAGUGGUC	m7b	Created	no TS	-0.134	-3.58
hsa-miR-361-3p	ttCTGGGGGAccacttgtc	0	UCCCCCAG	m8a	(m7a->m8a)	-0.194	-0.392	0.29
hsa-miR-4281	ttctggGGGACCacttgtc	0	GGGUCCCG	m6b	Created	no TS	-0.184	-1.26

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50860030G>A			ICGC_1441298		TCGA-AP-A059-01A-21D-A122-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1208	cgtcatgggACAGTGAacc	0	UCACUGUU	m7a	(m6b->m7a)	no TS	-0.045	-0.92
hsa-miR-1913	cgtcatGGGGCAGtgaacc	0	UCUGCCCC	m7b	Disrupted	-0.228	no TS	2.18
hsa-miR-3189-5p	cgtcATGGGGCAgtgaacc	0	UGCCCCAU	m8a	Disrupted	-0.316	no TS	-0.02
hsa-miR-324-3p	cgtcatGGGGCAGTgaacc	0	ACUGCCCC	m8a	Disrupted	-0.228	no TS	5.15
hsa-miR-4433-5p	cgtcaTGGGACagtgaacc	0	CGUCCCAC	m6b	Created	no TS	-0.112	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50860373A>T			COSN5761580		HX19T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4302	tgaggACACTGataggatg	2	CCAGUGUG	m6b	Created	-0.201000	-0.281000	1.220000
hsa-miR-5094	tgaggaCACTGATaggatg	0	AAUCAGUG	m7b	Created	no TS	-0.226000	-4.070000

Mutation			Mutation ID		Sample Name		Cancer Type
chr19:g.50860508A>C			0_562				Prostate cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3180	gcacaaCGCCCCAgacact	4	UGGGGCGG	m7a	Created	no TS	-0.229	-12.13
hsa-miR-3180-3p	gcacaaCGCCCCAgacact	4	UGGGGCGG	m7a	Created	no TS	-0.229	-13.73
hsa-miR-3196	gcacaaCGCCCCagacact	4	CGGGGCGG	m6b	Created	no TS	-0.236	-0.03
hsa-miR-4299	gcacaacgCACCAGacact	4	GCUGGUGA	m6b	Disrupted	-0.099	no TS	1.71
hsa-miR-4456	gcacaacgCACCAGacact	4	CCUGGUGG	m6b	Disrupted	-0.1	no TS	3.72
hsa-miR-4466	gcacaaCGCACCagacact	4	GGGUGCGG	m6b	Disrupted	-0.206	no TS	No effect
hsa-miR-4667-5p	gcacaacgCCCCAGacact	4	ACUGGGGA	m6b	Created	-0.118	-0.236	No effect
hsa-miR-4700-5p	gcacaacgCCCCAGAcact	4	UCUGGGGA	m7a	Created	-0.118	-0.243	-1.43
hsa-miR-548q	gcacaacGCACCAGacact	4	GCUGGUGC	m7b	Disrupted	-0.341	no TS	8.38
hsa-miR-637	gcacaacgCCCCAGacact	4	ACUGGGGG	m6b	Created	no TS	-0.126	-0.96
hsa-miR-675-5p	gcacaaCGCACCAgacact	4	UGGUGCGG	m7a	Disrupted	-0.213	no TS	0.02

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
50859651	rs201907046	G	G	hsa-miR-4268	0	tgtGAGGAGCcac	Disrupted	N	-0.213
			A	hsa-miR-1229-3p hsa-miR-342-3p hsa-miR-6815-3p	0	tGTGAGAAgccac TGTGAGAagccac tgtgAGAAGCCAc	Created Created Created	N N N	-0.091 -0.064 -0.292
50860030	rs200116262	G	G	hsa-miR-1913 hsa-miR-3189-5p hsa-miR-324-3p hsa-miR-4758-3p hsa-miR-5699-5p hsa-miR-6890-3p	2 2 2 2 2 2	catGGGGCAGtga cATGGGGCAgtga catGGGGCAGtga caTGGGGCAgtga caTGGGGCAgtga catggGGCAGTGA	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N	-0.228 -0.316 -0.228 -0.155 -0.151 -0.244
			A	hsa-miR-1208 hsa-miR-4433-5p hsa-miR-4433b-5p hsa-miR-6760-3p	2 2 2 2	catgggACAGTGA caTGGGACAgtga caTGGGACAgtga catggGACAGTGA	Created Created Created Created	N N N N	-0.045 -0.112 -0.157 -0.179

Genome Browser