SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000899
Gene Symbol:	KITLG
Description:	Homo sapiens KIT ligand (KITLG), transcript variant b, mRNA.
Gene Location:	chr12(-):88886569-88974250
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.88493359C>T			0_18				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1246	agaaatAATCCATgctaaa	15	AAUGGAUU	m7b	Disrupted	-0.128	no TS	No effect
hsa-miR-183-3p	agaaaTAATTCAtgctaaa	15	GUGAAUUA	m7b	Created	0.204	0.149	No effect
hsa-miR-490-5p	agaaataATCCATGctaaa	16	CCAUGGAU	m7b	Disrupted	-0.188	no TS	No effect
hsa-miR-944	agaAATAATTcatgctaaa	15	AAAUUAUU	m7b	(m6c->m7b)	no TS	0.051	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.88495229A>T			ICGC_sm74439		RK006_C02		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5007-3p	tgcttgagCATATGAaaat	0	AUCAUAUG	m7b	Disrupted	0.064	no TS	0.47
hsa-miR-99a-3p	tgcttGAGCTTatgaaaat	0	CAAGCUCG	m6b	Created	no TS	-0.036	-0.12
hsa-miR-99b-3p	tgcttGAGCTTatgaaaat	0	CAAGCUCG	m6b	Created	no TS	-0.036	-0.83

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.88495672C>T			0_19				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3646	ctttcctTTCATTTcaaaa	8	AAAAUGAA	m7b	Disrupted	0.241	0.101	2.35
hsa-miR-488-3p	ctttCCTTTCAtttcaaaa	8	UUGAAAGG	m7b	Disrupted	-0.02	no TS	No effect
hsa-miR-5681a	ctttCCTTTCatttcaaaa	20	AGAAAGGG	m6b	Disrupted	0.034	-0.003	0.06

Mutation			Mutation ID		Sample Name		Cancer Type
chr12:g.88497127A>G			ICGC_ssm_v3_46644		HCC116T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4517	caaatTCATATTctgtctg	0	AAAUAUGA	m7b	Disrupted	0.018	0.142	No effect
hsa-miR-589-3p	caaattcaTGTTCTGtctg	0	UCAGAACA	m7b	Created	0.052	-0.122	-0.25

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
88494328	rs41309419	C	C	hsa-miR-4427 hsa-miR-4680-3p hsa-miR-4762-3p hsa-miR-5187-3p	7 7 13 7	ctcATTCAGAaat ctcATTCAGAaat ctcatTCAGAAAt ctcATTCAGAaat	Disrupted Disrupted Disrupted Disrupted	N N N N	0.047 0.043 0.05 0.025
			T	hsa-miR-1252-3p hsa-miR-3646 hsa-miR-4263 hsa-miR-4799-5p hsa-miR-576-5p	3 4 14 7 13	CTCATTTAgaaat cTCATTTAgaaat ctcatTTAGAAAt ctcATTTAGAAat ctcatTTAGAAAt	Created Created Created Created Created	N N N N N	0.069 0.134 0.108 0.205 0.109
88496282	rs41300048	T	T	hsa-miR-203a	8	gtccCATTTCAAt	Disrupted	N	0.031
			A	hsa-miR-1302 hsa-miR-183-3p hsa-miR-219a-2-3p hsa-miR-219b-3p hsa-miR-3122 hsa-miR-3913-5p hsa-miR-4298 hsa-miR-4452	10 8 8 8 10 10 10 8	GTCCCAAttcaat gtcccAATTCAAt gtccCAATTCAat gtccCAATTCAat GTCCCAAttcaat GTCCCAAttcaat GTCCCAAttcaat gtcccAATTCAAt	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.126 0.08 0.015 0.015 -0.094 -0.132 -0.116 0.065

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