SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_183416
Gene Symbol: KIF1B
Description: Homo sapiens kinesin family member 1B (KIF1B), transcript variant 1, mRNA.
Gene Location: chr1(+):10270763-10368655
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.10306597T>C COSN7168480 8044424 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3913-3p atatggTGATGTCcctgaa
 1
 AGACAUCA m7b Disrupted 0.044000 -0.034000 No effect
hsa-miR-499a-3p atatgGTGATGTccctgaa
 0 AACAUCAC m7b Disrupted -0.002000 -0.093000 No effect
hsa-miR-499b-3p atatgGTGATGTccctgaa
 0 AACAUCAC m7b Disrupted 0.007000 -0.093000 0.070000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10307359C>G ICGC_6AD1506A-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1184 cccagGCTGCAGtgcagtg
 1
 CCUGCAGC m7b Disrupted 0.022 no TS No effect
hsa-miR-4418 cccaggCTGCAGTGcagtg
 0 CACUGCAG m8a Disrupted -0.001 -0.077 No effect
hsa-miR-508-5p cccaggCTGGAGTgcagtg
 0 UACUCCAG m7b Created no TS 0.045 -0.02
hsa-miR-509-3-5p cccaggCTGCAGTgcagtg
 0 UACUGCAG m7b Disrupted -0.011 -0.068 No effect
hsa-miR-509-5p cccaggCTGCAGTgcagtg
 0 UACUGCAG m7b Disrupted -0.029 -0.086 No effect
hsa-miR-766-3p cccagGCTGGAGTgcagtg
 0 ACUCCAGC m8a Created -0.011 0.004 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10307400C>T 0_39 Prostate cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1827 cctCTGCCTCctgggttca
 4
 UGAGGCAG m7b (m7b->m6b) -0.251 -0.217 No effect
hsa-miR-3612 cctcTGCCTCCTgggttca
 4
 AGGAGGCA m8a Disrupted -0.019 no TS No effect
hsa-miR-3714 cctCTGCCTTCtgggttca
 4
 GAAGGCAG m8a Created -0.32 -0.317 No effect
hsa-miR-4459 cctctgCCTCCTGGgttca
 4
 CCAGGAGG m8a Disrupted -0.01 -0.004 2.52
hsa-miR-4695-5p cctctGCCTCCTGggttca
 4
 CAGGAGGC m8a Disrupted -0.082 -0.04 0.23
hsa-miR-650 cctcTGCCTCCTgggttca
 4
 AGGAGGCA m8a Disrupted -0.019 no TS 0.01
hsa-miR-665 cctctgcCTCCTGGgttca
 4
 ACCAGGAG m7b Disrupted -0.04 -0.022 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10307538A>G ICGC_9291411E-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1258 cgaatTCCTAACctcaggt
 2
 AGUUAGGA m7b Disrupted -0.053 no TS 0.01
hsa-miR-377-5p cgaattcctAACCTCaggt
 0 AGAGGUUG m6b Disrupted 0.075 0.041 0.08
hsa-miR-873-5p cgaaTTCCTGacctcaggt
 0 GCAGGAAC m6b Created no TS 0.041 -0.04

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10307579A>G ICGC_9291461E-2A78-11E2-8335-12FD496BB9B8 CPCG_0102_Pr_P_P2 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-216a aaagtgcTGAGATTAcagg
 2
 UAAUCUCA m8a Disrupted 0.097 no TS 0.25
hsa-miR-216b aaagtgctGAGATTacagg
 0 AAAUCUCU m6b Disrupted 0.082 no TS 0.05
hsa-miR-4530 aaagTGCTGGGattacagg
 0 CCCAGCAG m7a Created NA NA -0.21
hsa-miR-4733-5p aaagtgcTGGGATTacagg
 0 AAUCCCAA m7a Created NA NA -0.23

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10308041A>G COSN6500345 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4255 aaacaaAACACTGaatttt
 0 CAGUGUUC m7a Disrupted NA NA No effect
hsa-miR-4276 aaacaaaaCACTGAatttt
 0 CUCAGUGA m6b Disrupted -0.191000 -0.079000 0.700000
hsa-miR-4302 aaacaaaACACTGaatttt
 0 CCAGUGUG m6b Disrupted -0.178000 -0.088000 0.070000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10308139G>A COSN8883501 AOCS-148-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3923 tgcctTACTAGTcctttgt
 0 AACUAGUA m7b Created no TS -0.104000 No effect
hsa-miR-4759 tgccttacTAGTCCTttgt
 10
 UAGGACUA m7b Created -0.113000 -0.263000 0.020000
hsa-miR-628-3p tgccTTACTAGtcctttgt
 0 UCUAGUAA m7b Created no TS -0.044000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10308431T>A COSN15575481 C0007T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376a-5p tttGAATCTACttgttaat
 2
 GUAGAUUC m8a Created -0.139000 -0.352000 -0.910000
hsa-miR-4699-5p tttgAATCTTCTtgttaat
 10
 AGAAGAUU m8a Disrupted -0.128000 no TS No effect
hsa-miR-5697 tttgaatCTACTTGttaat
 2
 UCAAGUAG m7b Created 0.062000 -0.191000 -2.860000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
10308026 rs142832592 - A hsa-miR-30a-3p
hsa-miR-30d-3p
hsa-miR-30e-3p
hsa-miR-335-3p
hsa-miR-4276
hsa-miR-4302
hsa-miR-6733-3p
0 acACTGAAAAaaa
acACTGAAAAaaa
acACTGAAAAaaa
acacTGAAAAAaa
aCACTGAAaaaaa
ACACTGAaaaaaa
ACACTGAaaaaaa
 Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
Unknown
N
N
N
N
N
N
N
 -0.003
-0.003
-0.003
-0.003
-0.002
-0.002
-0.004
-
10308041 rs17401588 A A hsa-miR-19a-5p
hsa-miR-19b-1-5p
hsa-miR-19b-2-5p
hsa-miR-2052
hsa-miR-4276
hsa-miR-4302
hsa-miR-6733-3p
5
5
5
5
21
5
5
 CAAAACActgaat
CAAAACActgaat
CAAAACActgaat
CAAAACActgaat
caaaaCACTGAAt
caaaACACTGAat
caaaACACTGAat
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
 -0.009
-0.012
-0.012
-0.008
-0.112
-0.09
-0.117

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