SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_015074
Gene Symbol: KIF1B
Description: Homo sapiens kinesin family member 1B (KIF1B), transcript variant 1, mRNA.
Gene Location: chr1(+):10270763-10441661
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.10376947G>T COSN1086008 HCC22T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-154-3p cttccttttGTATGATagg
 6
 AAUCAUAC m7b (m7b->m6c) -0.197000 -0.018000 0.430000
hsa-miR-4666a-3p cttccttTTGTATGatagg
 0 CAUACAAU m7a Disrupted NA NA 0.150000
hsa-miR-485-3p cttcctttTGTATGAtagg
 7
 GUCAUACA m7b Disrupted -0.120000 no TS 0.020000
hsa-miR-487a cttccttttGTATGATagg
 6
 AAUCAUAC m7b (m7b->m6c) -0.197000 -0.018000 3.610000
hsa-miR-539-3p cttcctttTGTATGATagg
 7
 AUCAUACA m8a Disrupted -0.129000 no TS 0.470000
hsa-miR-154-3p cttccttttGTATGATagg
 0 AAUCAUAC m7b (m7b->m6c) -0.197 -0.018 0.43
hsa-miR-4666a-3p cttccttTTGTATGatagg
 0 CAUACAAU m7a Disrupted NA NA 0.15
hsa-miR-485-3p cttcctttTGTATGAtagg
 0 GUCAUACA m7b Disrupted -0.12 no TS 0.02
hsa-miR-487a cttccttttGTATGATagg
 0 AAUCAUAC m7b (m7b->m6c) -0.197 -0.018 3.61
hsa-miR-539-3p cttcctttTGTATGATagg
 0 AUCAUACA m8a Disrupted -0.129 no TS 0.47

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10377427G>A COSN7168743 8016470 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1224-3p gcagcaggcGGTGGGatgc
 2
 CCCCACCU m6b Disrupted -0.080000 -0.018000 No effect
hsa-miR-1260a gcagcaggcGGTGGGATgc
 2
 AUCCCACC m8a (m8a->m7b) -0.077000 -0.010000 3.220000
hsa-miR-1260b gcagcaggcGGTGGGATgc
 2
 AUCCCACC m8a (m8a->m7b) -0.077000 -0.010000 2.910000
hsa-miR-1273g-3p gcagcagGCAGTGGgatgc
 1
 ACCACUGC m7b Created 0.086000 0.037000 No effect
hsa-miR-1280 gcagcaggCGGTGGGAtgc
 0 UCCCACCG m8a Disrupted -0.334000 -0.110000 2.290000
hsa-miR-3156-3p gcagcaggcAGTGGGAtgc
 2
 CUCCCACU m7b (m6c->m7b) 0.023000 0.020000 0.020000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10377636T>C COSN5729736 HX32T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-154-3p tcattgtTATGATTaagat
 6
 AAUCAUAC m7a Disrupted -0.197000 -0.197000 0.300000
hsa-miR-487a tcattgtTATGATTaagat
 6
 AAUCAUAC m7a Disrupted -0.197000 -0.197000 0.010000
hsa-miR-487b tcattgtTACGATTaagat
 0 AAUCGUAC m7a Created NA NA -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10377696G>T ICGC_BD691E70-2A78-11E2-BDED-1EFD496BB9B8 CPCG_0103_Pr_P_P4 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p caaGCACTTTgggaggccg
 0 AAAAGUGC m7b (m6b->m7b) -0.141 -0.076 -0.47
hsa-miR-106b-5p caaGCACTTTgggaggccg
 0 UAAAGUGC m7b (m6b->m7b) -0.151 -0.067 No effect
hsa-miR-150-5p caagcactTTGGGAGgccg
 0 UCUCCCAA m7b Created 0.161 0.187 -0.26
hsa-miR-17-5p caaGCACTTTGggaggccg
 0 CAAAGUGC m8a Created -0.141 -0.076 -0.47
hsa-miR-186-3p caagcaCTTTGGGaggccg
 0 GCCCAAAG m7b Created no TS 0.027 -0.95
hsa-miR-20a-5p caaGCACTTTgggaggccg
 0 UAAAGUGC m7b (m6b->m7b) -0.138 -0.063 -1.02
hsa-miR-20b-5p caaGCACTTTGggaggccg
 0 CAAAGUGC m8a Created -0.138 -0.063 -0.51
hsa-miR-372 caAGCACTTTgggaggccg
 0 AAAGUGCU m8a (m7a->m8a) -0.065 -0.093 No effect
hsa-miR-519d caaGCACTTTGggaggccg
 0 CAAAGUGC m8a Created -0.132 -0.067 No effect
hsa-miR-520a-3p caAGCACTTTgggaggccg
 0 AAAGUGCU m8a (m7a->m8a) -0.027 -0.055 No effect
hsa-miR-520b caAGCACTTTgggaggccg
 0 AAAGUGCU m8a (m7a->m8a) -0.056 -0.084 No effect
hsa-miR-520c-3p caAGCACTTTgggaggccg
 0 AAAGUGCU m8a (m7a->m8a) -0.056 -0.084 No effect
hsa-miR-520d-3p caAGCACTTTgggaggccg
 0 AAAGUGCU m8a (m7a->m8a) -0.018 -0.046 No effect
hsa-miR-520e caAGCACTTTgggaggccg
 0 AAAGUGCU m8a (m7a->m8a) -0.037 -0.065 No effect
hsa-miR-520g caagCACTTTGggaggccg
 0 ACAAAGUG m7b Created no TS 0.134 No effect
hsa-miR-520h caagCACTTTGggaggccg
 0 ACAAAGUG m7b Created no TS 0.134 No effect
hsa-miR-526b-3p caaGCACTTTgggaggccg
 0 GAAAGUGC m7b (m6b->m7b) -0.141 -0.076 -0.04
hsa-miR-93-5p caaGCACTTTGggaggccg
 0 CAAAGUGC m8a Created -0.129 -0.054 -0.02

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10377720C>T COSN6500436 CHC205T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1285-5p ggcagatcaTGAGATCagg
 2
 GAUCUCAC m7a (m6b->m7a) -0.053000 -0.053000 -0.010000
hsa-miR-433 ggcagATCATGAgatcagg
 1
 AUCAUGAU m7b Created -0.008000 0.052000 -0.110000
hsa-miR-4695-3p ggcagatcaTGAGATCAgg
 0 UGAUCUCA m8a (m7b->m8a) 0.008000 -0.074000 -0.870000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10378995C>T COSN5995486 RK171_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1279 tgatggacaCAATATGccc
 3
 UCAUAUUG m7b (m7b->m6c) 0.398000 0.262000 No effect
hsa-miR-3657 tgatGGACACAatatgccc
 8
 UGUGUCCC m7a Disrupted -0.031000 no TS No effect
hsa-miR-4669 tgatGGACACAatatgccc
 8
 UGUGUCCG m7a Disrupted -0.043000 no TS No effect
hsa-miR-599 tgatgGACACAAtatgccc
 0 GUUGUGUC m7b Disrupted -0.013000 -0.046000 No effect
hsa-miR-656 tgatggacATAATATgccc
 0 AAUAUUAU m7b Created no TS 0.240000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10379859G>A COSN8883651 AOCS-150-8-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1587 ggccagcCAGCCCAtgcgc
 5
 UUGGGCUG m7b Disrupted 0.047000 no TS No effect
hsa-miR-3064-5p ggcCAGCCAGcccatgcgc
 4
 UCUGGCUG m7b (m7b->m6b) -0.055000 -0.178000 No effect
hsa-miR-3940-5p ggccagcCAACCCAtgcgc
 0 GUGGGUUG m7b Created no TS 0.086000 No effect
hsa-miR-4492 ggccagCCAGCCCatgcgc
 5
 GGGGCUGG m7b Disrupted -0.067000 -0.061000 No effect
hsa-miR-4498 ggccagCCAGCCCAtgcgc
 5
 UGGGCUGG m8a Disrupted -0.068000 -0.051000 -0.020000
hsa-miR-4507 ggccagcCAACCCAtgcgc
 0 CUGGGUUG m7b Created no TS 0.077000 No effect
hsa-miR-4675 ggccagcCAGCCCatgcgc
 5
 GGGGCUGU m6b Disrupted 0.015000 no TS No effect
hsa-miR-4741 ggccagcCAGCCCatgcgc
 5
 CGGGCUGU m6b Disrupted 0.018000 no TS No effect
hsa-miR-5001-5p ggccagCCAGCCCatgcgc
 5
 AGGGCUGG m7b Disrupted -0.057000 -0.051000 No effect
hsa-miR-5580-5p ggccAGCCAGCccatgcgc
 6
 UGCUGGCU m7b Disrupted 0.083000 no TS -0.010000
hsa-miR-762 ggccagCCAGCCCatgcgc
 5
 GGGGCUGG m7b Disrupted -0.076000 -0.070000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.10380461A>T ICGC_6AD205AA-2A78-11E2-96E7-04FD496BB9B8 CPCG_0102_Pr_P_P1 ProstateCancer(OICR,CA)
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-106a-5p tcccaGCACTTTgggaggc
 0 AAAAGUGC m7b Created -0.141 -0.051 -0.02
hsa-miR-106b-5p tcccaGCACTTTgggaggc
 0 UAAAGUGC m7b Created -0.151 -0.042 No effect
hsa-miR-17-5p tcccaGCACTTTGggaggc
 0 CAAAGUGC m8a Created -0.141 -0.051 -0.02
hsa-miR-186-3p tcccagcaCTTTGGGaggc
 0 GCCCAAAG m7b Created no TS 0.034 -0.04
hsa-miR-20a-5p tcccaGCACTTTgggaggc
 0 UAAAGUGC m7b Created -0.138 -0.038 -0.04
hsa-miR-20b-5p tcccaGCACTTTGggaggc
 0 CAAAGUGC m8a Created -0.138 -0.038 -0.04
hsa-miR-302a-3p tcccAGCACTTtgggaggc
 0 UAAGUGCU m7b Created -0.009 0.091 No effect
hsa-miR-302b-3p tcccAGCACTTtgggaggc
 0 UAAGUGCU m7b Created -0.009 0.091 No effect
hsa-miR-302c-3p tcccAGCACTTtgggaggc
 0 UAAGUGCU m7b Created -0.009 0.091 No effect
hsa-miR-302d-3p tcccAGCACTTtgggaggc
 0 UAAGUGCU m7b Created -0.018 0.082 No effect
hsa-miR-302e tcccAGCACTTtgggaggc
 0 UAAGUGCU m7b Created 0 0.109 -0.01
hsa-miR-372 tcccAGCACTTTgggaggc
 0 AAAGUGCU m8a Created -0.065 0.016 No effect
hsa-miR-373-3p tcccAGCACTTtgggaggc
 0 GAAGUGCU m7b Created -0.037 0.044 No effect
hsa-miR-512-3p tccCAGCACTTtgggaggc
 0 AAGUGCUG m8a Created -0.17 -0.14 No effect
hsa-miR-519d tcccaGCACTTTGggaggc
 0 CAAAGUGC m8a Created -0.132 -0.042 No effect
hsa-miR-520a-3p tcccAGCACTTTgggaggc
 0 AAAGUGCU m8a Created -0.027 0.073 No effect
hsa-miR-520b tcccAGCACTTTgggaggc
 0 AAAGUGCU m8a Created -0.056 0.025 No effect
hsa-miR-520c-3p tcccAGCACTTTgggaggc
 0 AAAGUGCU m8a Created -0.056 0.025 No effect
hsa-miR-520d-3p tcccAGCACTTTgggaggc
 0 AAAGUGCU m8a Created -0.018 0.082 No effect
hsa-miR-520e tcccAGCACTTTgggaggc
 0 AAAGUGCU m8a Created -0.037 0.063 No effect
hsa-miR-520g tcccagCACTTTGggaggc
 0 ACAAAGUG m7b Created no TS 0.148 No effect
hsa-miR-520h tcccagCACTTTGggaggc
 0 ACAAAGUG m7b Created no TS 0.148 No effect
hsa-miR-526b-3p tcccaGCACTTTgggaggc
 0 GAAAGUGC m7b Created -0.141 -0.051 No effect
hsa-miR-93-5p tcccaGCACTTTGggaggc
 0 CAAAGUGC m8a Created -0.129 -0.029 -0.01

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
10377720 rs4240912 C
T hsa-miR-433-3p
hsa-miR-4695-3p
2
1
 agATCATGAgatc
agatcaTGAGATC
 Created
Created
N
N
 0.06
-0.082
10380461 rs201588744 A
T hsa-miR-106a-5p
hsa-miR-106b-5p
hsa-miR-17-5p
hsa-miR-186-3p
hsa-miR-20a-5p
hsa-miR-20b-5p
hsa-miR-302a-3p
hsa-miR-302b-3p
hsa-miR-302c-3p
hsa-miR-302d-3p
hsa-miR-302e
hsa-miR-372-3p
hsa-miR-373-3p
hsa-miR-512-3p
hsa-miR-519d-3p
hsa-miR-520a-3p
hsa-miR-520b
hsa-miR-520c-3p
hsa-miR-520d-3p
hsa-miR-520e
hsa-miR-520g-3p
hsa-miR-520h
hsa-miR-526b-3p
hsa-miR-93-5p
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
 caGCACTTTggga
caGCACTTTggga
caGCACTTTggga
cagcaCTTTGGGA
caGCACTTTggga
caGCACTTTggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
CAGCACTttggga
caGCACTTTggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cAGCACTTtggga
cagCACTTTGgga
cagCACTTTGgga
caGCACTTTggga
caGCACTTTggga
 Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
Created
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
N
 0.09
0.109
0.09
0.034
0.1
0.1
0.1
0.1
0.1
0.1
0.109
0.081
0.081
0.03
0.09
0.1
0.081
0.081
0.1
0.1
0.148
0.148
0.09
0.1

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