SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_004972
Gene Symbol:	JAK2
Description:	Homo sapiens Janus kinase 2 (JAK2), mRNA.
Gene Location:	chr9(+):4985244-5128183
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.5127064G>A			COSN1379015		HCC51T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-129-5p	ctgGCAAAAAaaaaaaaat	0	CUUUUUGC	m7b	(m6b->m7b)	no TS	-0.108000	-0.240000
hsa-miR-129-5p	ctgGCAAAAAaaaaaaaat	0	CUUUUUGC	m7b	(m6b->m7b)	no TS	-0.108	-0.24

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.5127339G>C			COSN9318389		J52_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3185	tgtgtcCTTCTTCatttat	9	AGAAGAAG	m7b	Created	-0.049000	-0.199000	-0.690000

Mutation			Mutation ID		Sample Name		Cancer Type
chr9:g.5127566A>T			COSN9713007		AOCS-122-1-4		[ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-587	tgttttttaTATGGAActa	0	UUUCCAUA	m7b	(m6c->m7b)	no TS	-0.097000	-1.850000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
5126913	rs41314565	G
			A	hsa-miR-129-5p hsa-miR-130a-5p hsa-miR-153-5p hsa-miR-23a-3p hsa-miR-23b-3p hsa-miR-23c hsa-miR-6885-3p	10 5 9 5 5 5 11	aGCAAAAAtgtga agcaaaAATGTGA agcAAAAATGtga agcaaaAATGTGA agcaaaAATGTGA agcaaaAATGTGA AGCAAAAatgtga	Created Created Created Created Created Created Created	N N N N N N N	-0.083 -0.189 0.021 -0.181 -0.181 -0.181 -0.067
5127687	rs115158615	A
			A	hsa-miR-3185 hsa-miR-4709-3p hsa-miR-5186	0	TTCTTCAatctct tTCTTCAAtctct ttcttCAATCTCt	Disrupted Disrupted Disrupted	N N N	-0.011 -0.04 -0.153

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