SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000210
Gene Symbol:	ITGA6
Description:	Homo sapiens integrin, alpha 6 (ITGA6), transcript variant 2, mRNA.
Gene Location:	chr2(+):173292313-173371181
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr2:g.172504203A>-			ICGC_ssm_v3_8903		BN24T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1305	ataaccTTGAAAAaaaaca	0	UUUUCAAC	m7a	Disrupted	-0.018000	-0.015000	No effect
hsa-miR-335-3p	ataacctTGAAAAAaaaca	0	UUUUUCAU	m7a	Disrupted	-0.049000	-0.042000	0.910000
hsa-miR-498	ataacCTTGAAAaaaaaca	0	UUUCAAGC	m7a	Disrupted	-0.004000	-0.001000	0.270000
hsa-miR-561-5p	ataaCCTTGAaaaaaaaca	0	AUCAAGGA	m6b	Disrupted	-0.165000	-0.163000	0.340000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
172504202	rs201055917	-	-	hsa-miR-1305 hsa-miR-335-3p hsa-miR-4761-5p hsa-miR-498 hsa-miR-561-5p	14 14 16 14 14	aaccTTGAAAAaa aacctTGAAAAAa aACCTTGAaaaaa aacCTTGAAAaaa aaCCTTGAAaaaa	Unknown Unknown Unknown Unknown Unknown	N N N N N	0.003 0.005 0.002 0.002 0.002
			A

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