SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_002460
Gene Symbol: IRF4
Description: Homo sapiens interferon regulatory factor 4 (IRF4), transcript variant 2, mRNA.
Gene Location: chr6(+):391738-411443
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr6:g.407806G>A COSN2161948 RK032_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-19a-5p cccaccCAAAACaagtgat
 0 AGUUUUGC m6b Created no TS -0.023000 No effect
hsa-miR-19b-1-5p cccaccCAAAACaagtgat
 0 AGUUUUGC m6b Created no TS -0.023000 No effect
hsa-miR-19b-2-5p cccaccCAAAACaagtgat
 0 AGUUUUGC m6b Created no TS -0.023000 No effect
hsa-miR-2052 cccaccCAAAACAagtgat
 0 UGUUUUGA m7a Created no TS -0.015000 -0.010000
hsa-miR-431-5p cccaccCAAGACAagtgat
 2
 UGUCUUGC m7a Disrupted -0.095000 no TS No effect
hsa-miR-511 cccacccAAGACAagtgat
 2
 GUGUCUUU m6b Disrupted 0.008000 0.059000 No effect
hsa-miR-635 cccaCCCAAGacaagtgat
 0 ACUUGGGC m6b Disrupted -0.110000 no TS 0.030000
hsa-miR-19a-5p cccaccCAAAACaagtgat
 0 AGUUUUGC m6b Created no TS -0.023 No effect
hsa-miR-19b-1-5p cccaccCAAAACaagtgat
 0 AGUUUUGC m6b Created no TS -0.023 No effect
hsa-miR-19b-2-5p cccaccCAAAACaagtgat
 0 AGUUUUGC m6b Created no TS -0.023 No effect
hsa-miR-2052 cccaccCAAAACAagtgat
 0 UGUUUUGA m7a Created no TS -0.015 -0.01
hsa-miR-431-5p cccaccCAAGACAagtgat
 2
 UGUCUUGC m7a Disrupted -0.095 no TS No effect
hsa-miR-511 cccacccAAGACAagtgat
 2
 GUGUCUUU m6b Disrupted 0.008 0.059 No effect
hsa-miR-635 cccaCCCAAGacaagtgat
 0 ACUUGGGC m6b Disrupted -0.11 no TS 0.03

Mutation Mutation ID Sample Name Cancer Type
chr6:g.407904C>A COSN8514326 1953_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3545-3p atttCAGTTCAgcggttga
 2
 UUGAACUG m7b Disrupted -0.084000 0.049000 0.060000
hsa-miR-4539 atttcAGTTCAGCggttga
 1
 GCUGAACU m8a Disrupted 0.001000 0.072000 No effect
hsa-miR-4804-3p atttcaGTTAAGCggttga
 0 UGCUUAAC m7b Created no TS -0.136000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408206G>A COSN6320584 RK121_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-200a-5p aaGTAAGATGtaaattgaa
 1
 CAUCUUAC m8a (m8a->m7a) -0.087000 -0.175000 No effect
hsa-miR-200b-5p aaGTAAGATGtaaattgaa
 1
 CAUCUUAC m8a (m8a->m7a) -0.087000 -0.175000 -0.030000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408445C>T COSN6320592 RK163_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3653 gtaaaCTTCTTAttttctt
 0 CUAAGAAG m7b Created 0.179000 0.111000 -0.020000
hsa-miR-4476 gtaaaCTTCCTattttctt
 1
 CAGGAAGG m6b Disrupted -0.033000 0.007000 0.790000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408577G>C COSN9783023 AOCS-094-1-1 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3675-3p ttcttTAGAGATGctaaaa
 0 CAUCUCUA m8a Disrupted -0.047000 no TS 0.220000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.408962A>G COSN6320606 RK028_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3144-3p acttgcttAGGTATAccta
 0 AUAUACCU m7b Created no TS 0.001000 -1.190000
hsa-miR-4503 actTGCTTAAgtataccta
 10
 UUUAAGCA m7b (m7b->m6b) 0.028000 no TS 1.870000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.409013C>G COSN9783043 AOCS-165-1-X [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4286 agcagtagAGTGGGGcgtc
 0 ACCCCACU m7b Created no TS -0.011000 -4.990000
hsa-miR-4758-3p agcagtagaGTGGGGCgtc
 0 UGCCCCAC m7b (m6c->m7b) no TS -0.103000 -5.150000
hsa-miR-934 agcAGTAGACtggggcgtc
 1
 UGUCUACU m7b (m7b->m6b) 0.072000 no TS 0.090000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.409318G>C COSN2161994 RK082_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-2117 caaacagtAGAGAACAgca
 4
 UGUUCUCU m8a Disrupted -0.027000 -0.052000 0.010000
hsa-miR-3686 caaacagTACAGAacagca
 1
 AUCUGUAA m6b Created 0.063000 0.115000 -0.010000
hsa-miR-4273 caaacagtaGAGAACAgca
 1
 GUGUUCUC m7b (m7b->m6c) 0.001000 no TS 1.740000
hsa-miR-4652-3p caaacagtACAGAACagca
 1
 GUUCUGUU m7a Created 0.148000 0.148000 No effect
hsa-miR-4684-5p caaacaGTAGAGAacagca
 8
 CUCUCUAC m7b Disrupted 0.025000 0.039000 0.210000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.409602T>C COSN9783067 AOCS-148-1-4 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3676-3p catgcAACACGGatatgta
 0 CCGUGUUU m7a Created NA NA -0.200000
hsa-miR-4716-5p catgcAACATGGAtatgta
 0 UCCAUGUU m8a Disrupted 0.126000 no TS No effect
hsa-miR-4800-3p catgcaacACGGATatgta
 0 CAUCCGUC m6b Created no TS -0.084000 -0.090000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410024A>C COSN4927767 PD4115a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4725-5p atcCAGGGTCTgacctagg
 0 AGACCCUG m8a Created no TS -0.055000 0.020000
hsa-miR-504 atcCAGGGTCTgacctagg
 0 AGACCCUG m8a Created no TS -0.093000 -2.760000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410514T>C COSN2162021 RK037_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-101-3p cttacaGTACTGTtaccac
 0 UACAGUAC m7b Created no TS -0.061000 -1.140000
hsa-miR-1278 cttaCAGTACTgttaccac
 0 UAGUACUG m7b Created no TS -0.081000 -0.440000
hsa-miR-194-5p cttacagtaCTGTTACcac
 1
 UGUAACAG m7b (m6c->m7b) -0.145000 -0.171000 No effect
hsa-miR-200b-3p cttaCAGTATTgttaccac
 4
 UAAUACUG m7b Disrupted -0.038000 -0.053000 0.010000
hsa-miR-200c-3p cttaCAGTATTgttaccac
 4
 UAAUACUG m7b Disrupted -0.047000 -0.053000 0.210000
hsa-miR-338-5p cttacagTATTGTTaccac
 0 AACAAUAU m7a Disrupted NA NA 5.007000
hsa-miR-429 cttaCAGTATTgttaccac
 4
 UAAUACUG m7b Disrupted -0.038000 -0.053000 0.530000
hsa-miR-101-3p cttacaGTACTGTtaccac
 0 UACAGUAC m7b Created no TS -0.061 -1.14
hsa-miR-1278 cttaCAGTACTgttaccac
 0 UAGUACUG m7b Created no TS -0.081 -0.44
hsa-miR-194-5p cttacagtaCTGTTACcac
 0 UGUAACAG m7b (m6c->m7b) -0.145 -0.171 No effect
hsa-miR-200b-3p cttaCAGTATTgttaccac
 1
 UAAUACUG m7b Disrupted -0.038 -0.053 0.01
hsa-miR-200c-3p cttaCAGTATTgttaccac
 1
 UAAUACUG m7b Disrupted -0.047 -0.053 0.21
hsa-miR-338-5p cttacagTATTGTTaccac
 0 AACAAUAU m7a Disrupted NA NA 5.007
hsa-miR-429 cttaCAGTATTgttaccac
 1
 UAAUACUG m7b Disrupted -0.038 -0.053 0.53

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410727C>T COSN4927771 PD4109a [breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3908 acttccgttCATTGCTCtc
 2
 GAGCAAUG m8a (m8a->m7b) -0.054000 no TS 2.110000
hsa-miR-3942-5p acttccgttTATTGCTctc
 0 AAGCAAUA m7b (m6c->m7b) no TS -0.019000 0.050000
hsa-miR-4703-5p acttccgttTATTGCTctc
 0 UAGCAAUA m7b (m6c->m7b) no TS -0.028000 -0.020000
hsa-miR-553 acttCCGTTTattgctctc
 0 AAAACGGU m6b Created no TS -0.120000 -0.700000
hsa-miR-887 acttCCGTTCAttgctctc
 0 GUGAACGG m7b Disrupted -0.215000 no TS 0.180000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.410998T>G COSN7882909 8035567 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-141-3p aaggtCAGTGTTtttttgt
 0 UAACACUG m7b Created no TS -0.155000 -0.050000
hsa-miR-200a-3p aaggtCAGTGTTtttttgt
 0 UAACACUG m7b Created no TS -0.155000 -0.240000
hsa-miR-548a-3p aaggtCAGTTTTtttttgt
 0 CAAAACUG m7b Disrupted -0.133000 no TS 3.240000
hsa-miR-548ae aaggtcAGTTTTTttttgt
 5
 CAAAAACU m7b Disrupted 0.009000 0.055000 1.370000
hsa-miR-548ah-3p aaggtcAGTTTTTttttgt
 5
 CAAAAACU m7b Disrupted 0.009000 0.055000 0.700000
hsa-miR-548aj-3p aaggtcAGTTTTTttttgt
 5
 UAAAAACU m7b Disrupted 0.009000 0.055000 1.360000
hsa-miR-548am-3p aaggtcAGTTTTTttttgt
 5
 CAAAAACU m7b Disrupted 0.009000 0.055000 1.280000
hsa-miR-548aq-3p aaggtcAGTTTTTttttgt
 5
 CAAAAACU m7b Disrupted 0.009000 0.055000 1.250000
hsa-miR-548ar-3p aaggtCAGTTTTtttttgt
 0 UAAAACUG m7b Disrupted -0.087000 no TS 0.070000
hsa-miR-548e aaggtCAGTTTTTttttgt
 0 AAAAACUG m8a Disrupted -0.124000 no TS 0.670000
hsa-miR-548f aaggtCAGTTTTTttttgt
 0 AAAAACUG m8a Disrupted -0.133000 no TS 0.080000
hsa-miR-548x-3p aaggtcAGTTTTTttttgt
 5
 UAAAAACU m7b Disrupted 0.009000 0.055000 1.360000

Mutation Mutation ID Sample Name Cancer Type
chr6:g.411331A>T COSN6320646 RK308_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3120-3p gataatgctTTGCTGTcgt
 2
 CACAGCAA m7b (m6c->m7b) 0.215000 0.068000 -0.010000
hsa-miR-330-3p gataaTGCTTTGCtgtcgt
 2
 GCAAAGCA m8a Created -0.021000 -0.210000 -0.370000
hsa-miR-4422 gataATGCTTTgctgtcgt
 6
 AAAAGCAU m7b Created 0.077000 -0.029000 -0.140000
hsa-miR-545-3p gataatgcTTTGCTGtcgt
 6
 UCAGCAAA m7b Created -0.064000 -0.201000 -0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



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