SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000207
Gene Symbol: INS
Description: Homo sapiens insulin (INS), transcript variant 1, mRNA.
Gene Location: chr11(-):2181008-2182439
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Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr11:g.2159809G>A COSN1080215 TCGA-BS-A0UV-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1250 tcctGCACCGagagagatg
 0 ACGGUGCU m6b Disrupted -0.224000 no TS 19.500000
hsa-miR-3615 tcctgcaCCGAGAGAgatg
 0 UCUCUCGG m8a Disrupted -0.517000 no TS 14.550000
hsa-miR-1250 tcctGCACCGagagagatg
 0 ACGGUGCU m6b Disrupted -0.224 no TS 19.5
hsa-miR-3615 tcctgcaCCGAGAGAgatg
 0 UCUCUCGG m8a Disrupted -0.517 no TS 14.55

Mutation Mutation ID Sample Name Cancer Type
chr11:g.2159842G>A COSN1080214 TCGA-AX-A0J0-01 [endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1587 acgCAGCCCAcaggcagcc
 0 UUGGGCUG m7b (m6c->m7b) no TS 0.000000 No effect
hsa-miR-4265 acgcaGCCCACAGgcagcc
 0 CUGUGGGC m8a Created no TS 0.000000 -1.630000
hsa-miR-4296 acgcaGCCCACAggcagcc
 0 AUGUGGGC m7b Created no TS 0.000000 -1.130000
hsa-miR-4322 acgcaGCCCACAGgcagcc
 0 CUGUGGGC m8a Created no TS 0.000000 -1.530000
hsa-miR-4417 acgcAGCCCACaggcagcc
 0 GGUGGGCU m7b Created no TS 0.000000 -0.330000
hsa-miR-4734 acgcagCCCGCAGgcagcc
 0 GCUGCGGG m7b Disrupted 0.000000 no TS No effect
hsa-miR-4763-5p acgcagcccGCAGGCagcc
 0 CGCCUGCC m6b Disrupted 0.000000 no TS No effect
hsa-miR-4767 acgcaGCCCGCaggcagcc
 0 CGCGGGCG m6b Disrupted 0.000000 no TS No effect
hsa-miR-1587 acgCAGCCCAcaggcagcc
 0 UUGGGCUG m7b (m6c->m7b) no TS 0 No effect
hsa-miR-4265 acgcaGCCCACAGgcagcc
 0 CUGUGGGC m8a Created no TS 0 -1.63
hsa-miR-4296 acgcaGCCCACAggcagcc
 0 AUGUGGGC m7b Created no TS 0 -1.13
hsa-miR-4322 acgcaGCCCACAGgcagcc
 0 CUGUGGGC m8a Created no TS 0 -1.53
hsa-miR-4417 acgcAGCCCACaggcagcc
 0 GGUGGGCU m7b Created no TS 0 -0.33
hsa-miR-4734 acgcagCCCGCAGgcagcc
 0 GCUGCGGG m7b Disrupted 0 no TS No effect
hsa-miR-4763-5p acgcagcccGCAGGCagcc
 0 CGCCUGCC m6b Disrupted 0 no TS No effect
hsa-miR-4767 acgcaGCCCGCaggcagcc
 0 CGCGGGCG m6b Disrupted 0 no TS No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
2159809 rs192030414 - G hsa-miR-1250-5p
hsa-miR-3615
hsa-miR-7110-3p
hsa-miR-8088
0 tGCACCGAgagag
tgcaCCGAGAGAg
tgcaccGAGAGAG
tgcACCGAGAgag
 Unknown
Unknown
Unknown
Unknown
N
N
N
N
 -0.224
-0.517
-0.181
-0.207
2159843 rs3842752 - C hsa-miR-4734
hsa-miR-4767
hsa-miR-6829-5p
1
1
0
 gcagCCCGCAGgc
gcaGCCCGCAggc
GCAGCCCgcaggc
 Unknown
Unknown
Unknown
N
N
N
 No Change
No Change
No Change
T hsa-miR-1205
hsa-miR-6511b-5p
hsa-miR-6811-5p
1
1
1
 gcagCCTGCAGgc
gcaGCCTGCAggc
gcaGCCTGCAggc
 Unknown
Unknown
Unknown
N
N
N
 No Change
No Change
No Change

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