| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_005534 |
|---|---|
| Gene Symbol: | IFNGR2 |
| Description: | Homo sapiens interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2), mRNA. |
| Gene Location: | chr21(+):34775201-34809828 |
| Browse Associations | |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.33436995G>A | cosmic_v64_1723809 | Lymphoma | T-cell | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1236 |
tggctccctGGAAGAGatc |
0 | CCUCUUCC | m7b | (m7b->m6c) | -0.278 | -0.058 |
-1.64 |
|
| hsa-miR-3162-5p |
tggCTCCCTAgaagagatc |
0 | UUAGGGAG | m7b | (m6b->m7b) | no TS | -0.176 |
-3.39 |
|
| hsa-miR-3180-5p |
tggctccCTGGAAGagatc |
0 | CUUCCAGA | m7a | Disrupted | -0.156 | -0.156 |
0.46 |
|
| hsa-miR-4270 |
tggCTCCCTGgaagagatc |
1 |
UCAGGGAG | m7b | (m7b->m6b) | -0.163 | no TS |
3.9 |
|
| hsa-miR-4441 |
tggCTCCCTGgaagagatc |
1 |
ACAGGGAG | m7b | (m7b->m6b) | -0.144 | no TS | No effect | |
| hsa-miR-4685-5p |
tggctCCCTGGaagagatc |
2 |
CCCAGGGC | m6b | Disrupted | -0.183 | no TS |
3.75 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr21:g.33437051G>C | COSN15576054 | C0007T | [kidney][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-140-5p |
cagagACCACTattccctt |
0 | CAGUGGUU | m6b | Created | no TS | -0.142000 |
-2.030000 |
|
| hsa-miR-200b-3p |
cagagacCAGTATTccctt |
2 |
UAAUACUG | m7b | Disrupted | -0.029000 | no TS |
0.650000 |
|
| hsa-miR-200c-3p |
cagagacCAGTATTccctt |
2 |
UAAUACUG | m7b | Disrupted | -0.029000 | no TS |
2.550000 |
|
| hsa-miR-3545-5p |
cagaGACCACTAttccctt |
0 | UAGUGGUC | m8a | Created | no TS | -0.427000 |
-1.030000 |
|
| hsa-miR-3663-5p |
cagAGACCAGtattccctt |
3 |
GCUGGUCU | m7b | (m7b->m6b) | -0.197000 | no TS |
3.580000 |
|
| hsa-miR-429 |
cagagacCAGTATTccctt |
2 |
UAAUACUG | m7b | Disrupted | -0.039000 | no TS |
2.850000 |
|
| hsa-miR-4460 |
cagagACCACTATtccctt |
0 | AUAGUGGU | m8a | Created | no TS | -0.187000 |
-0.030000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr21:g.33437126T>- | ICGC_sm163678 | RK046_C01 | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-100-3p |
ggtgaCAAGCTTttttttt |
0 | CAAGCUUG | m7b | Disrupted | -0.200000 | no TS |
2.660000 |
| hsa-miR-548ae |
ggtgacaAGTTTTTtttt |
0 | CAAAAACU | m7b | Created | -0.019000 | -0.081000 | No effect |
| hsa-miR-548ah-3p |
ggtgacaAGTTTTTtttt |
0 | CAAAAACU | m7b | Created | -0.019000 | -0.081000 | No effect |
| hsa-miR-548aj-3p |
ggtgacaAGTTTTTtttt |
0 | UAAAAACU | m7b | Created | -0.019000 | -0.081000 | No effect |
| hsa-miR-548am-3p |
ggtgacaAGTTTTTtttt |
0 | CAAAAACU | m7b | Created | -0.019000 | -0.081000 |
-0.010000 |
| hsa-miR-548aq-3p |
ggtgacaAGTTTTTtttt |
0 | CAAAAACU | m7b | Created | -0.019000 | -0.081000 | No effect |
| hsa-miR-548x-3p |
ggtgacaAGTTTTTtttt |
0 | UAAAAACU | m7b | Created | -0.019000 | -0.081000 | No effect |
| hsa-miR-5582-3p |
ggtgacAAGTTTTttttt |
0 | UAAAACUU | m7b | Created | no TS | -0.018000 |
-1.260000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 33437046 | rs148361896 | G | G |
hsa-miR-3191-5p hsa-miR-326 hsa-miR-330-5p hsa-miR-3663-5p hsa-miR-518c-5p hsa-miR-593-3p hsa-miR-6764-3p hsa-miR-6824-3p hsa-miR-6843-3p hsa-miR-6848-3p |
2 2 2 3 1 3 2 2 3 3 |
tCCAGAGAccagt tCCAGAGAccagt tCCAGAGAccagt tccagAGACCAGt TCCAGAGAccagt tcCAGAGACcagt tCCAGAGAccagt tCCAGAGAccagt tccaGAGACCAgt tccaGAGACCAgt |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N N N N |
-0.19 -0.125 -0.121 -0.197 -0.357 -0.16 -0.133 -0.137 -0.209 -0.219 |
| A |
hsa-miR-1299 hsa-miR-29b-1-5p hsa-miR-29b-2-5p hsa-miR-4782-5p hsa-miR-516b-5p hsa-miR-5706 |
1 3 3 1 1 1 |
TCCAGAAaccagt tccagAAACCAGt tccaGAAACCAgt TCCAGAAaccagt TCCAGAAaccagt TCCAGAAaccagt |
Created Created Created Created Created Created |
N N N N N N |
-0.157 -0.144 -0.144 -0.143 -0.12 -0.123 |
|||
| 33437127 | rs71657077 | - | T |
hsa-miR-100-3p |
5 |
aCAAGCTTttttt |
Unknown |
N |
-0.002 |
| - | |||||||||
| 33437127 | rs71727878 | - | - |
hsa-miR-100-3p |
5 |
aCAAGCTTttttt |
Unknown |
N |
0.001 |
| T |