SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001165923
Gene Symbol:	HNF1B
Description:	Homo sapiens HNF1 homeobox B (HNF1B), transcript variant 1, mRNA.
Gene Location:	chr17(-):36046433-36105096
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.37686980G>T			ICGC_ssm_v3_76010		HCC137T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-148a-5p	tattGAACTTagccaaaca	0	AAAGUUCU	m6b	Created	no TS	-0.035	-8.17
hsa-miR-24-3p	tattgaaCTGAGCCAaaca	0	UGGCUCAG	m8a	Disrupted	-0.399	no TS	7.56
hsa-miR-4277	tattGAACTGagccaaaca	0	GCAGUUCU	m6b	Disrupted	-0.078	no TS	10.88
hsa-miR-4284	tattgaacTGAGCCaaaca	0	GGGCUCAC	m6b	Disrupted	-0.14	no TS	0.47
hsa-miR-5000-5p	tatTGAACTGagccaaaca	0	CAGUUCAG	m7a	(m7a->m6b)	NA	NA	1.98

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.37687351C>T			cosmic_v64_1675361				Melanoma
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3973	cactTACTTTGTgcgcaac	0	ACAAAGUA	m8a	Created	no TS	-0.051	-0.99
hsa-miR-548a-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.029	No effect
hsa-miR-548ab	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548ak	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548am-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548ao-5p	cacTTACTTCgtgcgcaac	0	AGAAGUAA	m7b	(m7b->m6c)	-0.063	no TS	No effect
hsa-miR-548ap-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548aq-5p	cacTTACTTTgtgcgcaac	0	GAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548ar-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.029	No effect
hsa-miR-548as-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.019	No effect
hsa-miR-548au-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548ax	cacTTACTTCgtgcgcaac	0	AGAAGUAA	m7b	(m7b->m6c)	-0.063	no TS	No effect
hsa-miR-548b-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	-0.009	5.42
hsa-miR-548c-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548d-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	-0.009	No effect
hsa-miR-548h-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548i	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.029	No effect
hsa-miR-548j	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548o-5p	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548w	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-548y	cacTTACTTTgtgcgcaac	0	AAAAGUAA	m7b	(m6c->m7b)	no TS	0.01	No effect
hsa-miR-559	cacTTACTTTgtgcgcaac	0	UAAAGUAA	m7b	(m6c->m7b)	no TS	0.038	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
37687350	rs200421746	G
			A	hsa-miR-548ao-5p hsa-miR-548ax hsa-miR-5585-5p hsa-miR-8060	0	TACTTCAtgcgca TACTTCAtgcgca TACTTCAtgcgca taCTTCATGcgca	Created Created Created Created	N N N N	-0.14 -0.14 -0.071 -0.156

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