SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
  Home Search Help Download  

PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_000545
Gene Symbol: HNF1A
Description: Homo sapiens HNF1 homeobox A (HNF1A), mRNA.
Gene Location: chr12(+):121416548-121440314
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr12:g.121001344A>T COSN1143428 HCC29T [liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-204-5p atgcatcagAAAGGGAggg
 3
 UUCCCUUU m7b (m7b->m6c) -0.030000 no TS No effect
hsa-miR-211-5p atgcatcagAAAGGGAggg
 3
 UUCCCUUU m7b (m7b->m6c) -0.030000 no TS No effect
hsa-miR-4762-3p atgcATCAGAAagggaggg
 3
 CUUCUGAU m7b Disrupted -0.069000 no TS 6.530000
hsa-miR-204-5p atgcatcagAAAGGGAggg
 3
 UUCCCUUU m7b (m7b->m6c) -0.030000 no TS No effect
hsa-miR-211-5p atgcatcagAAAGGGAggg
 3
 UUCCCUUU m7b (m7b->m6c) -0.030000 no TS No effect
hsa-miR-4762-3p atgcATCAGAAagggaggg
 3
 CUUCUGAU m7b Disrupted -0.069000 no TS 6.530000
hsa-miR-204-5p atgcatcagAAAGGGAggg
 3
 UUCCCUUU m7b (m7b->m6c) -0.030000 no TS No effect
hsa-miR-211-5p atgcatcagAAAGGGAggg
 3
 UUCCCUUU m7b (m7b->m6c) -0.030000 no TS No effect
hsa-miR-4762-3p atgcATCAGAAagggaggg
 3
 CUUCUGAU m7b Disrupted -0.069000 no TS 6.530000
hsa-miR-204-5p atgcatcagAAAGGGAggg
 0 UUCCCUUU m7b (m7b->m6c) -0.03 no TS No effect
hsa-miR-211-5p atgcatcagAAAGGGAggg
 0 UUCCCUUU m7b (m7b->m6c) -0.03 no TS No effect
hsa-miR-4762-3p atgcATCAGAAagggaggg
 3
 CUUCUGAU m7b Disrupted -0.069 no TS 6.53

Mutation Mutation ID Sample Name Cancer Type
chr12:g.121001665C>A COSN8698143 AOCS-091-1-3 [ovary][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1225-5p caatGTACCCACcgggcca
 0 GUGGGUAC m8a Disrupted -0.146000 no TS 1.210000
hsa-miR-1263 caatGTACCAaccgggcca
 0 AUGGUACC m6b Created no TS -0.078000 -1.660000
hsa-miR-150-3p caaTGTACCAaccgggcca
 0 CUGGUACA m7b (m6b->m7b) no TS -0.234000 -0.010000
hsa-miR-4783-3p caatgtaccCACCGGGcca
 1
 CCCCGGUG m7b (m7b->m6c) -0.183000 no TS 1.990000

Mutation Mutation ID Sample Name Cancer Type
chr12:g.121001780G>A COSN1143430 HCC116T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3155a tgtgccaGAGCCTGGggct
 2
 CCAGGCUC m8a Disrupted -0.370000 -0.304000 No effect
hsa-miR-3155b tgtgccaGAGCCTGGggct
 2
 CCAGGCUC m8a Disrupted -0.370000 -0.304000 0.010000
hsa-miR-4726-3p tgtgccagaACCTGGGgct
 0 ACCCAGGU m7b (m6c->m7b) -0.357000 -0.531000 No effect
hsa-miR-484 tgtgccaGAGCCTGgggct
 2
 UCAGGCUC m7b Disrupted -0.436000 -0.398000 No effect
hsa-miR-760 tgtgcCAGAGCCtggggct
 1
 CGGCUCUG m7b Disrupted -0.055000 no TS 0.030000
hsa-miR-3155a tgtgccaGAGCCTGGggct
 2
 CCAGGCUC m8a Disrupted -0.370000 -0.304000 No effect
hsa-miR-3155b tgtgccaGAGCCTGGggct
 2
 CCAGGCUC m8a Disrupted -0.370000 -0.304000 0.010000
hsa-miR-4726-3p tgtgccagaACCTGGGgct
 0 ACCCAGGU m7b (m6c->m7b) -0.357000 -0.531000 No effect
hsa-miR-484 tgtgccaGAGCCTGgggct
 2
 UCAGGCUC m7b Disrupted -0.436000 -0.398000 No effect
hsa-miR-760 tgtgcCAGAGCCtggggct
 1
 CGGCUCUG m7b Disrupted -0.055000 no TS 0.030000
hsa-miR-3155a tgtgccaGAGCCTGGggct
 2
 CCAGGCUC m8a Disrupted -0.37 -0.304 No effect
hsa-miR-3155b tgtgccaGAGCCTGGggct
 2
 CCAGGCUC m8a Disrupted -0.37 -0.304 0.01
hsa-miR-4726-3p tgtgccagaACCTGGGgct
 0 ACCCAGGU m7b (m6c->m7b) -0.357 -0.531 No effect
hsa-miR-484 tgtgccaGAGCCTGgggct
 2
 UCAGGCUC m7b Disrupted -0.436 -0.398 No effect
hsa-miR-760 tgtgcCAGAGCCtggggct
 1
 CGGCUCUG m7b Disrupted -0.055 no TS 0.03

Mutation Mutation ID Sample Name Cancer Type
chr12:g.121001894G>T COSN1143432 HCC106T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3135b tgacCTCCAGCtttcctgt
 2
 GGCUGGAG m7b Disrupted -0.114000 no TS No effect
hsa-miR-320a tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320b tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320c tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320d tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320e tgacctCCAGCTTTcctgt
 2
 AAAGCUGG m8a Disrupted -0.079000 no TS 7.430000
hsa-miR-4426 tgacctCCATCTTtcctgt
 0 GAAGAUGG m7b Created no TS -0.031000 -6.760000
hsa-miR-4429 tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-4534 tgacCTCCATCtttcctgt
 0 GGAUGGAG m7b Created no TS -0.099000 -4.250000
hsa-miR-4647 tgacctCCATCTTtcctgt
 0 GAAGAUGG m7b Created no TS -0.049000 -17.900000
hsa-miR-4662b tgacctCCATCTTTcctgt
 0 AAAGAUGG m8a Created no TS -0.068000 -6.770000
hsa-miR-4802-5p tgaCCTCCATctttcctgt
 0 UAUGGAGG m7b (m6b->m7b) no TS -0.117000 -0.440000
hsa-miR-3135b tgacCTCCAGCtttcctgt
 2
 GGCUGGAG m7b Disrupted -0.114000 no TS No effect
hsa-miR-320a tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320b tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320c tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320d tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-320e tgacctCCAGCTTTcctgt
 2
 AAAGCUGG m8a Disrupted -0.079000 no TS 7.430000
hsa-miR-4426 tgacctCCATCTTtcctgt
 0 GAAGAUGG m7b Created no TS -0.031000 -6.760000
hsa-miR-4429 tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018000 no TS 4.470000
hsa-miR-4534 tgacCTCCATCtttcctgt
 0 GGAUGGAG m7b Created no TS -0.099000 -4.250000
hsa-miR-4647 tgacctCCATCTTtcctgt
 0 GAAGAUGG m7b Created no TS -0.049000 -17.900000
hsa-miR-4662b tgacctCCATCTTTcctgt
 0 AAAGAUGG m8a Created no TS -0.068000 -6.770000
hsa-miR-4802-5p tgaCCTCCATctttcctgt
 0 UAUGGAGG m7b (m6b->m7b) no TS -0.117000 -0.440000
hsa-miR-3135b tgacCTCCAGCtttcctgt
 2
 GGCUGGAG m7b Disrupted -0.114 no TS No effect
hsa-miR-320a tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018 no TS 4.47
hsa-miR-320b tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018 no TS 4.47
hsa-miR-320c tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018 no TS 4.47
hsa-miR-320d tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018 no TS 4.47
hsa-miR-320e tgacctCCAGCTTTcctgt
 2
 AAAGCUGG m8a Disrupted -0.079 no TS 7.43
hsa-miR-4426 tgacctCCATCTTtcctgt
 0 GAAGAUGG m7b Created no TS -0.031 -6.76
hsa-miR-4429 tgacctcCAGCTTTcctgt
 2
 AAAAGCUG m7b Disrupted 0.018 no TS 4.47
hsa-miR-4534 tgacCTCCATCtttcctgt
 0 GGAUGGAG m7b Created no TS -0.099 -4.25
hsa-miR-4647 tgacctCCATCTTtcctgt
 0 GAAGAUGG m7b Created no TS -0.049 -17.9
hsa-miR-4662b tgacctCCATCTTTcctgt
 0 AAAGAUGG m8a Created no TS -0.068 -6.77
hsa-miR-4802-5p tgaCCTCCATctttcctgt
 0 UAUGGAGG m7b (m6b->m7b) no TS -0.117 -0.44

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
121001781 rs55962050 C C hsa-miR-3155a
hsa-miR-3155b
hsa-miR-484
hsa-miR-760
2
2
2
1
 ccaGAGCCTGggg
ccaGAGCCTGggg
ccaGAGCCTGggg
cCAGAGCCtgggg
 Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
 -0.066
-0.066
-0.038
-0.055
T hsa-miR-4522
hsa-miR-514a-5p
1
2
 cCAGAGTCtgggg
CCAGAGTctgggg
 Created
Created
N
N
 -0.039
-0.058

Genome Browser