SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_139010
Gene Symbol:	HFE
Description:	Homo sapiens hemochromatosis (HFE), transcript variant 1, mRNA.
Gene Location:	chr6(+):26087508-26095469
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.26094619C>T			COSN4954927		SS6003308		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1915-3p	agctttgaaCCCTGGGacg	1	CCCCAGGG	m7b	(m7b->m6c)	-0.396000	-0.133000	0.220000
hsa-miR-4685-5p	agctttgaaCCCTGGGacg	2	CCCAGGGC	m7a	(m7a->m6b)	-0.153000	-0.153000	0.020000
hsa-miR-1915-3p	agctttgaaCCCTGGGacg	1	CCCCAGGG	m7b	(m7b->m6c)	-0.396000	-0.133000	0.220000
hsa-miR-4685-5p	agctttgaaCCCTGGGacg	2	CCCAGGGC	m7a	(m7a->m6b)	-0.153000	-0.153000	0.020000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.26094698C>A			COSN5086718		HCC154		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-105-5p	caacttttCATTTGAatcc	0	UCAAAUGC	m7a	Created	no TS	0.000000	-9.020000
hsa-miR-3646	caacttTTCATTTgaatcc	0	AAAAUGAA	m7b	Created	0.114000	0.128000	-0.030000
hsa-miR-3671	caacttttcATTTGAatcc	0	AUCAAAUA	m6b	Created	no TS	0.032000	-9.470000
hsa-miR-607	caacttttcATTTGAAtcc	0	GUUCAAAU	m7b	(m6c->m7b)	no TS	0.064000	0.330000
hsa-miR-105-5p	caacttttCATTTGAatcc	0	UCAAAUGC	m7a	Created	no TS	0.000000	-9.020000
hsa-miR-3646	caacttTTCATTTgaatcc	0	AAAAUGAA	m7b	Created	0.114000	0.128000	-0.030000
hsa-miR-3671	caacttttcATTTGAatcc	0	AUCAAAUA	m6b	Created	no TS	0.032000	-9.470000
hsa-miR-607	caacttttcATTTGAAtcc	0	GUUCAAAU	m7b	(m6c->m7b)	no TS	0.064000	0.330000

Mutation			Mutation ID		Sample Name		Cancer Type
chr6:g.26094891A>C			COSN1330288		BN37T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3145-3p	gtaggaggcAAATATCTtg	2	AGAUAUUU	m8a	(m8a->m7b)	0.036000	no TS	0.010000
hsa-miR-3152-5p	gtagGAGGCAAatatcttg	2	AUUGCCUC	m7b	Disrupted	-0.356000	no TS	7.860000
hsa-miR-4757-5p	gtagGAGGCCaatatcttg	0	AGGCCUCU	m6b	Created	no TS	-0.186000	-6.640000
hsa-miR-4774-3p	gtaggAGGCAAatatcttg	2	AUUGCCUA	m6b	Disrupted	-0.125000	no TS	9.660000
hsa-miR-3145-3p	gtaggaggcAAATATCTtg	0	AGAUAUUU	m8a	(m8a->m7b)	0.036	no TS	0.01
hsa-miR-3152-5p	gtagGAGGCAAatatcttg	2	AUUGCCUC	m7b	Disrupted	-0.356	no TS	7.86
hsa-miR-4757-5p	gtagGAGGCCaatatcttg	0	AGGCCUCU	m6b	Created	no TS	-0.186	-6.64
hsa-miR-4774-3p	gtaggAGGCAAatatcttg	2	AUUGCCUA	m6b	Disrupted	-0.125	no TS	9.66

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

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