SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000849
Gene Symbol:	GSTM3
Description:	Homo sapiens glutathione S-transferase mu 3 (brain) (GSTM3), transcript variant 1, mRNA.
Gene Location:	chr1(-):110276553-110283660
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109734781A>G			COSN6502311		CHC205T		[liver][NS][carcinoma][hepatocellular_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3130-3p	aggaataGTGCAGacagaa	0	GCUGCACC	m6b	Created	no TS	-0.073000	-3.850000
hsa-miR-4288	aggaatagtGCAGACAgaa	1	UUGUCUGC	m7b	(m6b->m7b)	-0.256000	-0.393000	-0.390000
hsa-miR-4793-3p	aggaatAGTGCAGAcagaa	0	UCUGCACU	m8a	Created	no TS	-0.179000	-4.830000
hsa-miR-632	aggaatagtGCAGACAgaa	1	GUGUCUGC	m7b	(m6b->m7b)	-0.224000	-0.333000	-0.900000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109735350T>A			COSN7171688		8016470		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4282	tcccaaAAATTTTttttaa	0	UAAAAUUU	m7b	Disrupted	0.172000	0.169000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109735634A>T			COSN15616050		C0066T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-33a-3p	aaaaaaaAAACATTcaaag	0	CAAUGUUU	m7b	Disrupted	0.135000	0.049000	0.130000
hsa-miR-409-3p	aaaaaaaaAACATTCaaag	3	GAAUGUUG	m7a	Disrupted	-0.066000	-0.066000	0.040000
hsa-miR-4307	aaaaaaAAAACATTcaaag	0	AAUGUUUU	m8a	Disrupted	0.036000	no TS	0.250000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109736549A>C			COSN14523856		8034061		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1245b-3p	actaaaatTCATCTGgaat	1	UCAGAUGA	m7b	Created	-0.119000	-0.285000	-5.160000
hsa-miR-4775	actAAAATTAAtctggaat	0	UUAAUUUU	m8a	Disrupted	0.289000	0.201000	0.010000
hsa-miR-590-3p	acTAAAATTAatctggaat	0	UAAUUUUA	m8a	(m8a->m7b)	0.494000	0.481000	0.050000
hsa-miR-1245b-3p	actaaaatTCATCTGgaat	1	UCAGAUGA	m7b	Created	-0.119000	-0.285000	-5.160000
hsa-miR-4775	actAAAATTAAtctggaat	0	UUAAUUUU	m8a	Disrupted	0.289000	0.201000	0.010000
hsa-miR-590-3p	acTAAAATTAatctggaat	0	UAAUUUUA	m8a	(m8a->m7b)	0.494000	0.481000	0.050000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109736974C>A			COSN1079618		TCGA-AP-A059-01		[endometrium][NS][carcinoma][endometrioid_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-302c-5p	cttATGTTAAtggtgtcca	6	UUUAACAU	m7b	(m6c->m7b)	0.039000	-0.026000	-0.350000
hsa-miR-802	cttaTGTTACTGgtgtcca	1	CAGUAACA	m8a	Disrupted	-0.345000	-0.175000	0.580000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109736995C>T			COSN520626		TCGA-AR-A24U-01		[breast][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change

No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.109737051A>G			COSN8635315		J10_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-2276	gaCTTGCAGAgcttgtttt	0	UCUGCAAG	m8a	(m8a->m7b)	0.000000	0.000000	No effect
hsa-miR-3173-5p	gacttGCAGGGCttgtttt	0	UGCCCUGC	m7b	Created	no TS	-0.348000	No effect
hsa-miR-3194-3p	gacttGCAGAGCTtgtttt	4	AGCUCUGC	m8a	Disrupted	-0.314000	-0.022000	0.010000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
109734781	rs3814309	A
			G	hsa-miR-3130-3p hsa-miR-346 hsa-miR-4288 hsa-miR-4793-3p hsa-miR-632	4 5 5 4 5	aataGTGCAGAca aatagtGCAGACA aatagtGCAGACA aatAGTGCAGAca aatagtGCAGACA	Created Created Created Created Created	N N N N N	-0.073 -0.081 -0.137 -0.179 -0.109
109735632	rs145782236	-	-	hsa-miR-33a-3p hsa-miR-4307	0	aaaAAACATTcaaag aaAAAACATtcaaag	Unknown Unknown	N N	0.086 0.036
			TC
109735633	rs66838501	-	-	hsa-miR-33a-3p hsa-miR-4307	0	aaaaAAACATTcaaa aaaAAAACATtcaaa	Unknown Unknown	N N	0.086 0.036
			TC	hsa-miR-1246 hsa-miR-1290 hsa-miR-3167 hsa-miR-876-5p	0	aaaaaAATCCATtcaaa aaaAAAATCCAttcaaa aaaaAAATCCAttcaaa aaaaAAATCCAttcaaa	Unknown Unknown Unknown Unknown	N N N N	-0.047 0.054 0.036 0.025
109735634	rs10857798	-	A	hsa-miR-33a-3p hsa-miR-4307	0	aaaaAAACATTca aaaAAAACATtca	Unknown Unknown	N N	0.086 0.036
			T	hsa-miR-580-5p	0	aaaaAATCATTca	Unknown	N	0.061
109735635	rs10857799	-	A	hsa-miR-33a-3p hsa-miR-4307	0	aaaaaAAACATTc aaaaAAAACATtc	Unknown Unknown	N N	0.086 0.036

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