SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_014394
Gene Symbol:	GHITM
Description:	Homo sapiens growth hormone inducible transmembrane protein (GHITM), mRNA.
Gene Location:	chr10(+):85899184-85913311
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.84152448G>T			COSN5292339		RK140_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-141-5p	tgaagtttaGAAGATaaga	5	CAUCUUCC	m6b	Disrupted	-0.104000	no TS	0.210000
hsa-miR-200a-5p	tgaagtttaTAAGATaaga	0	CAUCUUAC	m6b	Created	no TS	-0.082000	-0.510000
hsa-miR-200b-5p	tgaagtttaTAAGATaaga	0	CAUCUUAC	m6b	Created	no TS	-0.082000	No effect
hsa-miR-4799-5p	tgaagTTTAGAagataaga	0	AUCUAAAU	m6b	Disrupted	-0.225000	-0.190000	0.080000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.84152673G>T			COSN8640582		J90_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4264	aggttcACTGAGTaactaa	0	ACUCAGUC	m7a	Disrupted	NA	NA	0.050000
hsa-miR-4276	aggtTCACTGAGtaactaa	1	CUCAGUGA	m8a	Disrupted	-0.169000	no TS	2.550000
hsa-miR-510	aggttcaCTGAGTAactaa	1	UACUCAGG	m7a	Disrupted	-0.116000	no TS	No effect
hsa-miR-512-5p	aggttcaCTGAGTaactaa	1	CACUCAGC	m6b	Disrupted	-0.119000	no TS	0.740000
hsa-miR-5190	aggtTCACTGagtaactaa	1	CCAGUGAC	m6b	Disrupted	-0.101000	no TS	0.140000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
84153533	rs200657588	A	A	hsa-miR-410-3p hsa-miR-4799-5p	1 1	aGTTATATttaga agttatATTTAGA	Disrupted Disrupted	N N	-0.128 -0.15
			G	hsa-miR-4803	1	agTTATGTTtaga	Created	N	-0.083

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