SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000154
Gene Symbol:	GALK1
Description:	Homo sapiens galactokinase 1 (GALK1), mRNA.
Gene Location:	chr17(-):73754017-73761280
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr17:g.75757989G>A			COSN9673956		C0091T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1285-3p	tctgTGCCCAGtgccatct	0	UCUGGGCA	m7b	Created	no TS	-0.167000	-3.810000
hsa-miR-3187-5p	tctgTGCCCAGtgccatct	0	CCUGGGCA	m7b	Created	no TS	-0.176000	-3.820000
hsa-miR-5189	tctgTGCCCAGtgccatct	0	UCUGGGCA	m7b	Created	no TS	-0.148000	-1.720000
hsa-miR-593-5p	tctgtgcccGGTGCCatct	0	AGGCACCA	m6b	Disrupted	-0.192000	no TS	-0.650000
hsa-miR-612	tctgTGCCCAGtgccatct	0	GCUGGGCA	m7b	Created	no TS	-0.139000	-3.820000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
75757990	rs147878654	C	C	hsa-miR-181d-3p	1	tgtgCCCGGTGcc	Disrupted	N	-0.264
			T	hsa-miR-1911-3p hsa-miR-4269 hsa-miR-4645-5p hsa-miR-4673 hsa-miR-4733-3p hsa-miR-5582-5p hsa-miR-593-5p hsa-miR-6715b-5p	1 1 1 1 1 1 1 1	tgtGCCTGGTgcc tGTGCCTGgtgcc tgTGCCTGGtgcc tgTGCCTGGtgcc tgtgCCTGGTGcc TGTGCCTggtgcc tgtgccTGGTGCC tGTGCCTGgtgcc	Created Created Created Created Created Created Created Created	N N N N N N N N	-0.213 -0.211 -0.142 -0.198 -0.163 -0.105 -0.23 -0.173

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