SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database
Prediction criteria: TargetScan sites only     All 6mer or longer seed matches
RefSeq ID: NM_017737
Gene Symbol: FNBP1L
Description: Homo sapiens formin binding protein 1-like (FNBP1L), transcript variant 1, mRNA.
Gene Location: chr1(+):93913687-94020218
Browse Associations

Somatic mutations that impact miRNA target sites


Mutation Mutation ID Sample Name Cancer Type
chr1:g.93552692C>T 0_46 Lung cancer
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4524b-3p tattgCTGTCTaatcaata
 7
 GAGACAGG m6b Disrupted -0.141 no TS 0.02

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93552828T>A COSN1463856 RK032_C01 [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-181b-3p ctgTCAGTGActgcctgcg
 0 CUCACUGA m7b (m6b->m7b) no TS -0.049000 -0.610000
hsa-miR-2682-5p ctgtcagtgACTGCCTGcg
 2
 CAGGCAGU m8a (m7b->m8a) -0.229000 -0.312000 -0.090000
hsa-miR-3166 ctgtcagTGTCTGCctgcg
 16
 CGCAGACA m7b Disrupted -0.087000 no TS 2.250000
hsa-miR-34b-5p ctgtcagtgACTGCCTgcg
 2
 UAGGCAGU m7b (m6c->m7b) -0.201000 -0.274000 No effect
hsa-miR-4420 ctgTCAGTGACtgcctgcg
 0 GUCACUGA m8a Created no TS -0.039000 -4.560000
hsa-miR-449c-5p ctgtcagtgACTGCCTgcg
 2
 UAGGCAGU m7b (m6c->m7b) -0.192000 -0.265000 No effect
hsa-miR-4704-3p ctgtcaGTGACTGcctgcg
 12
 UCAGUCAC m7b Created -0.186000 -0.282000 No effect
hsa-miR-181b-3p ctgTCAGTGActgcctgcg
 0 CUCACUGA m7b (m6b->m7b) no TS -0.049 -0.61
hsa-miR-2682-5p ctgtcagtgACTGCCTGcg
 0 CAGGCAGU m8a (m7b->m8a) -0.229 -0.312 -0.09
hsa-miR-3166 ctgtcagTGTCTGCctgcg
 16
 CGCAGACA m7b Disrupted -0.087 no TS 2.25
hsa-miR-34b-5p ctgtcagtgACTGCCTgcg
 0 UAGGCAGU m7b (m6c->m7b) -0.201 -0.274 No effect
hsa-miR-4420 ctgTCAGTGACtgcctgcg
 0 GUCACUGA m8a Created no TS -0.039 -4.56
hsa-miR-449c-5p ctgtcagtgACTGCCTgcg
 0 UAGGCAGU m7b (m6c->m7b) -0.192 -0.265 No effect
hsa-miR-4704-3p ctgtcaGTGACTGcctgcg
 0 UCAGUCAC m7b Created -0.186 -0.282 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93553587->T cosmic_v64_1870281 NA [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1323 gatcatGTTTTGAtaattac
 0 UCAAAACU m7a Created 0.118000 0.165000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93553668A>G COSN15258826 LP6007520-DNA_A01 [oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-376c taatgaTCTATGTgcactt
 13
 AACAUAGA m7b Disrupted -0.071000 no TS -0.050000
hsa-miR-5694 taATGATCTGtgtgcactt
 13
 CAGAUCAU m8a (m7a->m8a) -0.121000 -0.066000 0.050000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93553692G>C COSN10056433 C0063T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-33a-5p tgtaaAATGCAatttctgt
 0 GUGCAUUG m6b Created no TS -0.023000 -6.220000
hsa-miR-33b-5p tgtaaAATGCAatttctgt
 0 GUGCAUUG m6b Created no TS -0.023000 -0.010000

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93553731T>C COSN8638891 3844_T [lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-3529-3p gaTTGTTGTTagtgctcct
 6
 AACAACAA m8a (m8a->m7a) -0.031000 -0.003000 0.190000
hsa-miR-888-3p gattgtTGTCAGTgctcct
 12
 GACUGACA m7b Created -0.059000 -0.112000 No effect

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93554109A>G COSN1110247 HX14T [liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-5000-5p gcagctagTGAACTataaa
 0 CAGUUCAG m6b Created no TS -0.066000 -0.010000
hsa-miR-5000-5p gcagctagTGAACTataaa
 0 CAGUUCAG m6b Created no TS -0.066 -0.01

Mutation Mutation ID Sample Name Cancer Type
chr1:g.93554400C>G COSN6952928 8062307 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4671-5p atttgCTTCGGTaggaggc
 0 ACCGAAGA m7a Created NA NA -0.100000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table
Location SNP ID Ancestral
Allele		 Allele miR ID Conservation miRSite FuncClass Validation context+
score change
93552829 rs76996025 C C hsa-miR-1910-3p
hsa-miR-3166
hsa-miR-4514
hsa-miR-4692
hsa-miR-6511a-5p
19
16
19
19
19
 cagtgTCTGCCTg
cagTGTCTGCctg
cagtgtCTGCCTG
cagtgtCTGCCTG
cagtgTCTGCCTg
 Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
 -0.073
-0.087
-0.098
-0.117
-0.064
T hsa-miR-141-3p
hsa-miR-200a-3p
hsa-miR-4470
hsa-miR-4742-5p
12
12
17
19
 CAGTGTTtgcctg
CAGTGTTtgcctg
cagtGTTTGCCtg
cagtgtTTGCCTG
 Created
Created
Created
Created
N
N
N
N
 -0.055
-0.046
-0.098
-0.082

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