SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_001024948
Gene Symbol:	FNBP1L
Description:	Homo sapiens formin binding protein 1-like (FNBP1L), transcript variant 1, mRNA.
Gene Location:	chr1(+):93913687-94020218
Browse Associations

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93552692C>T			0_46				Lung cancer
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4524b-3p	tattgCTGTCTaatcaata	7	GAGACAGG	m6b	Disrupted	-0.007	no TS	0.02

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93552828T>A			COSN1463856		RK032_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-181b-3p	ctgTCAGTGActgcctgcg	0	CUCACUGA	m7b	(m6b->m7b)	no TS	0.106000	-0.430000
hsa-miR-2682-5p	ctgtcagtgACTGCCTGcg	2	CAGGCAGU	m8a	(m7b->m8a)	-0.229000	-0.158000	-0.090000
hsa-miR-3166	ctgtcagTGTCTGCctgcg	16	CGCAGACA	m7b	Disrupted	0.068000	no TS	2.160000
hsa-miR-34b-5p	ctgtcagtgACTGCCTgcg	2	UAGGCAGU	m7b	(m6c->m7b)	-0.201000	-0.120000	No effect
hsa-miR-4420	ctgTCAGTGACtgcctgcg	0	GUCACUGA	m8a	Created	no TS	0.116000	-0.770000
hsa-miR-449c-5p	ctgtcagtgACTGCCTgcg	2	UAGGCAGU	m7b	(m6c->m7b)	-0.192000	-0.111000	No effect
hsa-miR-4704-3p	ctgtcaGTGACTGcctgcg	12	UCAGUCAC	m7b	Created	-0.186000	-0.127000	No effect
hsa-miR-181b-3p	ctgTCAGTGActgcctgcg	0	CUCACUGA	m7b	(m6b->m7b)	no TS	0.106	-0.43
hsa-miR-2682-5p	ctgtcagtgACTGCCTGcg	0	CAGGCAGU	m8a	(m7b->m8a)	-0.229	-0.158	-0.09
hsa-miR-3166	ctgtcagTGTCTGCctgcg	16	CGCAGACA	m7b	Disrupted	0.068	no TS	2.16
hsa-miR-34b-5p	ctgtcagtgACTGCCTgcg	0	UAGGCAGU	m7b	(m6c->m7b)	-0.201	-0.12	No effect
hsa-miR-4420	ctgTCAGTGACtgcctgcg	0	GUCACUGA	m8a	Created	no TS	0.116	-0.77
hsa-miR-449c-5p	ctgtcagtgACTGCCTgcg	0	UAGGCAGU	m7b	(m6c->m7b)	-0.192	-0.111	No effect
hsa-miR-4704-3p	ctgtcaGTGACTGcctgcg	0	UCAGUCAC	m7b	Created	-0.186	-0.127	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93553587->T			cosmic_v64_1870281		NA		[upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1323	gatcatGTTTTGAtaattac	0	UCAAAACU	m7a	Created	0.241000	0.288000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93553668A>G			COSN15258826		LP6007520-DNA_A01		[oesophagus][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-376c	taatgaTCTATGTgcactt	13	AACAUAGA	m7b	Disrupted	-0.071000	no TS	-0.050000
hsa-miR-5694	taATGATCTGtgtgcactt	13	CAGAUCAU	m8a	(m7a->m8a)	-0.121000	-0.066000	0.040000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93553692G>C			COSN10056433		C0063T		[kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-33a-5p	tgtaaAATGCAatttctgt	0	GUGCAUUG	m6b	Created	no TS	-0.023000	-4.670000
hsa-miR-33b-5p	tgtaaAATGCAatttctgt	0	GUGCAUUG	m6b	Created	no TS	-0.023000	-0.010000

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93553731T>C			COSN8638891		3844_T		[lung][NS][carcinoma][squamous_cell_carcinoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3529-3p	gaTTGTTGTTagtgctcct	6	AACAACAA	m8a	(m8a->m7a)	-0.031000	-0.003000	0.020000
hsa-miR-888-3p	gattgtTGTCAGTgctcct	12	GACUGACA	m7b	Created	0.097000	0.044000	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93554109A>G			COSN1110247		HX14T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-5000-5p	gcagctagTGAACTataaa	0	CAGUUCAG	m6b	Created	no TS	-0.066000	No effect
hsa-miR-5000-5p	gcagctagTGAACTataaa	0	CAGUUCAG	m6b	Created	no TS	-0.066	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.93554400C>G			COSN6952928		8062307		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4671-5p	atttgCTTCGGTaggaggc	0	ACCGAAGA	m7a	Created	NA	NA	-0.020000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
93551467	rs56045377	A	A	hsa-miR-4762-3p hsa-miR-548ao-5p hsa-miR-548ax hsa-miR-5585-5p	8 3 3 3	tactTCAGAAAac TACTTCAgaaaac TACTTCAgaaaac TACTTCAgaaaac	Disrupted Disrupted Disrupted Disrupted	N N N N	-0.031 -0.107 -0.107 -0.057
			G	hsa-miR-4671-5p	6	taCTTCGGAaaac	Created	N	-0.203

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