SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000143
Gene Symbol:	FH
Description:	Homo sapiens fumarate hydratase (FH), nuclear gene encoding mitochondrial protein, mRNA.
Gene Location:	chr1(-):241660856-241683085
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr1:g.241497775C>G			COSN7212022		8053117		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3199	aaaaacagAGTCCCatttc	0	AGGGACUG	m6b	Created	no TS	-0.228000	-9.020000
hsa-miR-365a-5p	aaaaacagAGTCCCatttc	0	AGGGACUU	m6b	Created	no TS	-0.230000	-5.640000
hsa-miR-365b-5p	aaaaacagAGTCCCatttc	0	AGGGACUU	m6b	Created	no TS	-0.227000	-5.640000
hsa-miR-3664-5p	aaaaACAGAGTcccatttc	0	AACUCUGU	m7b	Created	no TS	-0.235000	-6.280000
hsa-miR-4294	aaaaacAGACTCCCatttc	8	GGGAGUCU	m8a	Disrupted	-0.247000	no TS	9.530000
hsa-miR-4522	aaaaaCAGAGTCccatttc	0	UGACUCUG	m7b	Created	no TS	-0.295000	-7.790000

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
241497776	rs201081927	A	A	hsa-miR-4294	8	aaacAGACTCCca	Disrupted	N	-0.247
			G	hsa-miR-4300 hsa-miR-5591-5p hsa-miR-6090 hsa-miR-6726-5p hsa-miR-6827-5p hsa-miR-920	8 8 8 8 8 8	aaacagGCTCCCA aaacagGCTCCCA aaacagGCTCCCA aaacagGCTCCCA aaacaGGCTCCCA aaacagGCTCCCA	Created Created Created Created Created Created	N N N N N N	-0.264 -0.26 -0.267 -0.264 -0.613 -0.264
241497777	rs199704478	G	G	hsa-miR-4294	8	aaaacAGACTCCc	Disrupted	N	-0.247
			A	hsa-miR-8068	5	aaAACAAACtccc	Created	N	-0.189

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