SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_001163213 |
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Gene Symbol: | FGFR3 |
Description: | Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 1, mRNA. |
Gene Location: | chr4(+):1795038-1810599 |
Browse Associations | |
Browse Pathways |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807398T>C | COSN7756798 | 8035388 | [pancreas][NS][carcinoma][NS] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3939 |
gtgtgtgTGCGCGTgtgtg |
0 | UACGCGCA | m7b | Created | no TS | -0.348000 |
0.810000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807399GC>- | cosmic_v64_1860011 | NA | [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807401GT>- | cosmic_v64_1860011 | NA | [upper_aerodigestive_tract][mouth][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807404T>C | cosmic_v64_1860011 | Esophageal | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807412T>G | COSN8490446 | J32_T | [lung][NS][carcinoma][squamous_cell_carcinoma] | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-329 |
gtgtgtgtgGGTGTGTgca |
0 | AACACACC | m7b | (m6c->m7b) | no TS | -0.100000 |
0.470000 |
|
hsa-miR-362-3p |
gtgtgtgtgGGTGTGTgca |
0 | AACACACC | m7b | (m6c->m7b) | no TS | -0.100000 |
0.830000 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807635G>A | cosmic_v64_1760524 | Leukemia/T-ALL | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-19a-3p |
tctgccTTTGCACcacggg |
1 |
UGUGCAAA | m7b | Disrupted | 0.023 | no TS | No effect | |
hsa-miR-19b-3p |
tctgccTTTGCACcacggg |
1 |
UGUGCAAA | m7b | Disrupted | 0.023 | no TS | No effect | |
hsa-miR-518a-5p |
tctgcCTTTGCAccacggg |
2 |
CUGCAAAG | m7b | Disrupted | 0.028 | no TS | No effect | |
hsa-miR-527 |
tctgcCTTTGCAccacggg |
2 |
CUGCAAAG | m7b | Disrupted | 0.028 | no TS | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr4:g.1807921T>C | cosmic_v64_1760547 | Leukemia/T-ALL | |||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-297 |
tataACATACATggaagag |
0 | AUGUAUGU | m8a | Created | -0.077 | -0.203 |
1.85 |
|
hsa-miR-4716-5p |
tataacatACATGGAagag |
0 | UCCAUGUU | m7a | Created | no TS | -0.071 |
-0.97 |
|
hsa-miR-567 |
tatAACATACatggaagag |
0 | AGUAUGUU | m7b | (m6b->m7b) | no TS | -0.139 |
-1.61 |
|
hsa-miR-587 |
tataacataTATGGAAgag |
0 | UUUCCAUA | m7b | (m7b->m6c) | -0.086 | no TS |
1.77 |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr4:g.1807995G>A | COSN5012423 | SS6003323 | [oesophagus][NS][carcinoma][adenocarcinoma] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-3173-5p |
gccctggGCAGGGCgtggg |
0 | UGCCCUGC | m7b | Created | -0.185000 | -0.212000 |
-0.050000 |
hsa-miR-3173-5p |
gccctggGCAGGGCgtggg |
0 | UGCCCUGC | m7b | Created | -0.185000 | -0.212000 |
-0.050000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
1807729 | rs139197142 | G | G |
hsa-miR-21-3p hsa-miR-3591-3p |
3 3 |
gcctggGGTGTTA gcctggGGTGTTA |
Disrupted Disrupted |
N N |
-0.022 -0.039 |
T |
hsa-miR-1911-3p hsa-miR-329-3p hsa-miR-362-3p hsa-miR-4733-3p |
3 3 3 5 |
GCCTGGTgtgtta gcctGGTGTGTta gcctGGTGTGTta gCCTGGTGtgtta |
Created Created Created Created |
N N N N |
-0.2 -0.106 -0.153 -0.108 |