| SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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| RefSeq ID: | NM_000140 |
|---|---|
| Gene Symbol: | FECH |
| Description: | Homo sapiens ferrochelatase (FECH), nuclear gene encoding mitochondrial protein, transcript variant 2, mRNA. |
| Gene Location: | chr18(-):55212072-55253969 |
| Browse Pathways | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57545029A>G | COSN6128588 | RK190_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1246 |
aaccttgatAATCCATgta |
2 |
AAUGGAUU | m7b | (m7b->m6b) | -0.193000 | no TS | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57545736C>T | COSN1749168 | RK092_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4536-3p |
ccatATGCACGtattttgc |
2 |
UCGUGCAU | m7b | Disrupted | -0.226000 | no TS |
0.640000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57547382C>T | COSN9224841 | 8051716 | [pancreas][NS][carcinoid-endocrine_tumour][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1226-5p |
aggtccctCCCTCAacacg |
2 |
GUGAGGGC | m6b | Disrupted | -0.061000 | -0.084000 | No effect | |
| hsa-miR-1321 |
aggtcCCTCCCTcaacacg |
2 |
CAGGGAGG | m7b | Disrupted | 0.010000 | no TS |
0.930000 |
|
| hsa-miR-149-3p |
aggtCCCTCCCTcaacacg |
1 |
AGGGAGGG | m8a | Disrupted | -0.056000 | -0.032000 |
0.050000 |
|
| hsa-miR-3126-5p |
aggtcccTCCCTCAacacg |
2 |
UGAGGGAC | m7a | Disrupted | 0.040000 | 0.003000 | No effect | |
| hsa-miR-4419a |
aggtccCTCCCTCAacacg |
2 |
UGAGGGAG | m8a | Disrupted | 0.000000 | no TS |
0.160000 |
|
| hsa-miR-4510 |
aggtccCTCCCTCAacacg |
2 |
UGAGGGAG | m8a | Disrupted | 0.021000 | no TS |
0.050000 |
|
| hsa-miR-4728-5p |
aggtCCCTCCCtcaacacg |
1 |
UGGGAGGG | m7b | Disrupted | -0.046000 | -0.022000 | No effect | |
| hsa-miR-4739 |
aggtcCCTCCCTcaacacg |
2 |
AAGGGAGG | m7b | Disrupted | 0.019000 | no TS | No effect | |
| hsa-miR-4756-5p |
aggtcCCTCCCTcaacacg |
2 |
CAGGGAGG | m7b | Disrupted | 0.038000 | no TS | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57547688T>A | COSN9841050 | C0052T | [kidney][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-143-5p |
ttgcaccACTGCACtccag |
2 |
GGUGCAGU | m7b | Disrupted | 0.126000 | 0.056000 | No effect | |
| hsa-miR-512-3p |
ttgcaccaCAGCACTccag |
0 | AAGUGCUG | m7b | Created | no TS | 0.067000 | No effect | |
| hsa-miR-5693 |
ttgcaCCACTGCactccag |
0 | GCAGUGGC | m7a | Disrupted | NA | NA | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57547872C>A | COSN15357142 | AOCS-034-3-8 | [ovary][NS][other][neoplasm] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57547947C>A | COSN4906666 | CPCG_0006_Pr_P_F0 | [prostate][NS][carcinoma][adenocarcinoma] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-135a-5p |
ttaaAAGCCATttaaatgt |
1 |
UAUGGCUU | m7b | Created | 0.056000 | 0.015000 |
-0.800000 |
|
| hsa-miR-135b-5p |
ttaaAAGCCATttaaatgt |
1 |
UAUGGCUU | m7b | Created | 0.056000 | 0.015000 |
-0.380000 |
|
| hsa-miR-224-3p |
ttaaaagCCATTTaaatgt |
0 | AAAAUGGU | m6b | Created | 0.021000 | 0.101000 |
-1.720000 |
|
| hsa-miR-3119 |
ttAAAAGCCAtttaaatgt |
10 |
UGGCUUUU | m8a | (m7b->m8a) | -0.136000 | -0.133000 | No effect | |
| hsa-miR-3158-3p |
ttaaAAGCCCTTtaaatgt |
6 |
AAGGGCUU | m8a | Disrupted | -0.333000 | -0.231000 |
1.410000 |
|
| hsa-miR-4694-3p |
ttaaaagCCATTTaaatgt |
14 |
CAAAUGGA | m6b | Created | -0.093000 | -0.019000 |
-0.440000 |
|
| hsa-miR-522-3p |
ttaaaagCCATTTaaatgt |
0 | AAAAUGGU | m6b | Created | 0.021000 | 0.091000 |
-0.600000 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57548303C>T | COSN1749169 | RK100_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-7-1-3p |
caaaATTTGTTtcgtatca |
5 |
CAACAAAU | m7b | Created | 0.394000 | 0.503000 |
0.060000 |
|
| hsa-miR-7-2-3p |
caaaATTTGTTtcgtatca |
5 |
CAACAAAU | m7b | Created | 0.385000 | 0.494000 |
0.010000 |
|
| hsa-miR-7-1-3p |
caaaATTTGTTtcgtatca |
0 | CAACAAAU | m7b | Created | 0.394 | 0.503 |
0.06 |
|
| hsa-miR-7-2-3p |
caaaATTTGTTtcgtatca |
0 | CAACAAAU | m7b | Created | 0.385 | 0.494 |
0.01 |
|
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57548597G>T | COSN6128589 | RK190_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57549312G>T | COSN1207632 | HX13T | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57549384C>G | COSN7363998 | 8069319 | [pancreas][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-4699-5p |
ttcataAATCTTCTatatt |
2 |
AGAAGAUU | m8a | Disrupted | -0.033000 | no TS | No effect | |
| hsa-miR-4729 |
ttcATAAATGttctatatt |
2 |
UCAUUUAU | m7b | (m6c->m7b) | -0.077000 | 0.048000 | No effect | |
| hsa-miR-4773 |
ttcataaaTGTTCTatatt |
0 | CAGAACAG | m6b | Created | no TS | 0.019000 | No effect | |
| hsa-miR-5197-3p |
ttcataaaTCTTCTatatt |
0 | AAGAAGAG | m6b | Disrupted | 0.134000 | 0.114000 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
|---|---|---|---|---|---|---|---|---|---|
| chr18:g.57549645A>G | COSN1749170 | RK042_C01 | [liver][NS][carcinoma][NS] | ||||||
| miRNA Targets Table | |||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
| hsa-miR-1256 |
gatatttttAATGCCattt |
1 |
AGGCAUUG | m6b | Disrupted | -0.111000 | -0.050000 |
0.170000 |
|
| hsa-miR-3613-3p |
gataTTTTTGatgccattt |
2 |
ACAAAAAA | m6b | Created | 0.524000 | 0.678000 | No effect | |
| hsa-miR-4642 |
gatatttttGATGCCATtt |
5 |
AUGGCAUC | m8a | (m7a->m8a) | -0.067000 | -0.235000 |
0.040000 |
|
| hsa-miR-548c-3p |
gatATTTTTGatgccattt |
3 |
CAAAAAUC | m7a | (m6b->m7a) | 1.436000 | 1.245000 | No effect | |
| hsa-miR-1256 |
gatatttttAATGCCattt |
0 | AGGCAUUG | m6b | Disrupted | -0.111 | -0.05 |
0.17 |
|
| hsa-miR-3613-3p |
gataTTTTTGatgccattt |
0 | ACAAAAAA | m6b | Created | 0.524 | 0.678 |
-12.13 |
|
| hsa-miR-4642 |
gatatttttGATGCCATtt |
0 | AUGGCAUC | m8a | (m7a->m8a) | -0.067 | -0.235 |
0.04 |
|
| hsa-miR-548c-3p |
gatATTTTTGatgccattt |
0 | CAAAAAUC | m7a | (m6b->m7a) | 1.436 | 1.245 | No effect | |
| Mutation | Mutation ID | Sample Name | Cancer Type | |||||
|---|---|---|---|---|---|---|---|---|
| chr18:g.57550689C>T | COSN6128590 | RK308_C01 | [liver][NS][carcinoma][NS] | |||||
| miRNA Targets Table | ||||||||
| miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
| hsa-miR-122-3p |
accccgTGGCGTTaggcaa |
0 | AACGCCAU | m7a | Disrupted | NA | NA |
7.670000 |
| hsa-miR-21-3p |
accccgTGGTGTTaggcaa |
0 | CAACACCA | m7b | Created | -0.132000 | -0.319000 |
-4.940000 |
| hsa-miR-3591-3p |
accccgTGGTGTTaggcaa |
0 | AAACACCA | m7b | Created | -0.149000 | -0.357000 |
-3.370000 |
| hsa-miR-614 |
accccgtGGCGTTaggcaa |
0 | GAACGCCU | m6b | Disrupted | -0.201000 | no TS |
2.310000 |
| Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
|---|---|---|---|---|---|---|---|---|---|
| 57545232 | rs77084734 | T | T |
hsa-miR-495-3p hsa-miR-5688 hsa-miR-7-1-3p hsa-miR-7-2-3p |
12 12 12 12 |
gagccTTTGTTAt gagccTTTGTTAt gagccTTTGTTAt gagccTTTGTTAt |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
0.048 0.052 0.062 0.062 |
| C |
hsa-miR-2467-5p |
4 |
GAGCCTCtgttat |
Created |
N |
-0.266 |
|||
| 57545741 | rs114530851 | A | A |
hsa-miR-3688-3p hsa-miR-448 hsa-miR-4536-3p hsa-miR-8076 |
2 2 6 2 |
TTCCATAtgcacg ttccATATGCAcg ttccatATGCACG tTCCATATgcacg |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.037 -0.001 -0.226 -0.065 |
| G |
hsa-miR-4717-3p hsa-miR-4802-3p hsa-miR-5589-3p |
2 2 2 |
ttCCATGTGcacg tTCCATGTgcacg ttcCATGTGCAcg |
Created Created Created |
N N N |
-0.106 -0.093 -0.161 |
|||
| 57545826 | rs7238897 | T | T |
hsa-miR-3121-3p hsa-miR-3613-3p |
2 2 |
TCTATTTtttttg tctattTTTTTTG |
Disrupted Disrupted |
N N |
-0.039 0.068 |
| 57547021 | rs148141502 | C | C |
hsa-miR-122-5p hsa-miR-143-5p hsa-miR-504-3p hsa-miR-6499-3p |
0 |
ccactgCACTCCA ccACTGCACtcca ccactGCACTCCA cCACTGCActcca |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
0.026 0.056 -0.035 0.06 |
| 57549424 | rs1126640 | A | A |
hsa-miR-4794 hsa-miR-664a-5p hsa-miR-892b |
17 17 17 |
tttttTAGCCAGt tttttTAGCCAGt ttttttAGCCAGT |
Disrupted Disrupted Disrupted |
N N N |
-0.126 -0.191 -0.155 |
| T |
hsa-miR-3128 hsa-miR-3613-3p hsa-miR-4470 |
17 0 0 |
tttttTTGCCAGt tTTTTTTGccagt ttttTTTGCCAgt |
Created Created Created |
N N N |
-0.218 0.119 -0.024 |
|||
| 57549501 | rs62092522 | G | G |
hsa-miR-520d-5p hsa-miR-524-5p |
10 10 |
gaaTTTGTAAaga gaaTTTGTAAaga |
Disrupted Disrupted |
N N |
0.133 0.123 |
| T |
hsa-miR-302b-5p hsa-miR-302d-5p hsa-miR-548c-3p |
2 2 10 |
gaatttTTAAAGA gaatttTTAAAGA gaATTTTTAaaga |
Created Created Created |
N N N |
0.116 0.116 0.223 |
|||
| 57550289 | rs184781583 | G | G |
hsa-miR-1206 hsa-miR-124-5p hsa-miR-4729 hsa-miR-5696 hsa-miR-579-3p hsa-miR-664b-3p hsa-miR-6853-3p |
3 1 2 2 4 4 3 |
ttaaATGAACAca ttaaaTGAACACA tTAAATGAacaca tTAAATGAAcaca ttAAATGAAcaca ttAAATGAAcaca ttaAATGAACAca |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.066 -0.314 0.03 -0.055 0.009 0.013 -0.198 |
| 57550290 | rs3760612 | T | T |
hsa-miR-1206 hsa-miR-124-5p hsa-miR-4729 hsa-miR-5696 hsa-miR-579-3p hsa-miR-664b-3p hsa-miR-6853-3p |
3 1 2 2 4 4 3 |
tttaaATGAACAc tttaaaTGAACAC ttTAAATGAacac ttTAAATGAAcac tttAAATGAAcac tttAAATGAAcac tttaAATGAACAc |
Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted |
N N N N N N N |
-0.066 -0.201 0.03 -0.055 0.009 0.013 -0.198 |
| A |
hsa-miR-2116-5p hsa-miR-22-5p hsa-miR-4677-5p |
3 3 3 |
tttaaAAGAACAc tttaaAAGAACAc tttaaAAGAACAc |
Created Created Created |
N N N |
-0.051 -0.055 -0.13 |
|||
| 57550376 | rs1788012 | T | T |
hsa-miR-4433-3p hsa-miR-4459 hsa-miR-4768-3p hsa-miR-4779 |
2 2 2 2 |
ccCTCCTGAaagg cCCTCCTGAaagg ccCTCCTGAaagg CCCTCCTgaaagg |
Disrupted Disrupted Disrupted Disrupted |
N N N N |
-0.104 -0.292 -0.081 -0.22 |
| C |
hsa-miR-149-3p hsa-miR-425-3p hsa-miR-4728-5p hsa-miR-6746-5p hsa-miR-6771-5p hsa-miR-6785-5p hsa-miR-6883-5p |
2 2 2 2 2 2 2 |
CCCTCCCgaaagg cccTCCCGAAagg CCCTCCCgaaagg ccCTCCCGAaagg ccCTCCCGAAagg CCCTCCCgaaagg CCCTCCCgaaagg |
Created Created Created Created Created Created Created |
N N N N N N N |
-0.265 -0.196 -0.265 -0.193 -0.453 -0.227 -0.227 |