SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_152872
Gene Symbol:	FAS
Description:	Homo sapiens Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1, mRNA.
Gene Location:	chr10(+):90750287-90775542
Browse Associations
Browse Pathways

Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014243C>A			ICGC_1374802		TCGA-B5-A0JY-01A-11D-A10B-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-let-7a-2-3p	tgacaaTGTACAagacaca	0	CUGUACAG	m6b	Created	no TS	-0.07	-0.88
hsa-let-7g-3p	tgacaaTGTACAagacaca	0	CUGUACAG	m6b	Created	no TS	-0.073	-1.01
hsa-miR-4520b-3p	tgacaaTGTCCAAgacaca	0	UUUGGACA	m7b	Disrupted	-0.214	no TS	0.37
hsa-miR-493-5p	tgacaATGTACAAgacaca	0	UUGUACAU	m8a	Created	no TS	-0.262	-6.08
hsa-miR-643	tgacaatgTACAAGacaca	0	ACUUGUAU	m6b	Created	no TS	-0.096	-5.55

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014244C>G			ICGC_ssm_433		tumor_4163639		[haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][diffuse_large_B_cell_lymphoma]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-4520b-3p	gacaaTGTCCAAgacacag	0	UUUGGACA	m7b	Disrupted	-0.214	no TS	0.37

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014311C>T			ICGC_1374803		TCGA-AP-A051-01A-21W-A027-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-103a-2-5p	agaAAGAAGCgtatgacac	0	AGCUUCUU	m7b	(m7b->m6b)	-0.251	-0.086	2.33
hsa-miR-485-3p	agaaagaagTGTATGACac	0	GUCAUACA	m8a	(m7b->m8a)	-0.054	-0.209	-1.04
hsa-miR-539-3p	agaaagaagTGTATGAcac	0	AUCAUACA	m7b	(m6c->m7b)	-0.061	-0.225	-0.63

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014312G>A			ICGC_1374804		TCGA-AX-A0J1-01A-11W-A062-09		UterineCorpusEndometrioidCarcinoma(TCGA,US)
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-485-3p	gaaagaagcGTATGACaca	0	GUCAUACA	m7a	(m7a->m6b)	-0.054	-0.054	0.41
hsa-miR-5007-3p	gaaagaagCATATGAcaca	0	AUCAUAUG	m7b	Created	-0.082	-0.182	-0.16

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014550A>G			COSN5888337		RK190_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	actgggtacATTTTATcat	0	UAUAAAAU	m7b	(m7b->m6c)	0.037000	no TS	0.020000
hsa-miR-3662	actgggtaCATTTTatcat	0	GAAAAUGA	m6b	Disrupted	0.153000	0.094000	0.290000
hsa-miR-424-3p	actgggtACGTTTTatcat	0	CAAAACGU	m7b	Created	no TS	-0.187000	-0.100000
hsa-miR-548ad	actgggtaCGTTTTatcat	0	GAAAACGA	m6b	Created	no TS	-0.054000	1.000000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014996A>G			COSN1124101		HX17T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-302a-5p	agaaTTTAAGTaaggctct	2	ACUUAAAC	m7a	Created	-0.041000	-0.041000	No effect
hsa-miR-302a-5p	agaaTTTAAGTaaggctct	0	ACUUAAAC	m7a	Created	-0.041	-0.041	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89015535C>A			COSN7074141		8013946		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1275	tcataCCCCCAagtttcta	1	GUGGGGGA	m6b	Disrupted	-0.573000	-0.377000	0.010000
hsa-miR-3170	tcatACCCCAaagtttcta	2	CUGGGGUU	m6b	Created	-0.127000	-0.325000	No effect
hsa-miR-4665-5p	tcataCCCCCAagtttcta	1	CUGGGGGA	m6b	Disrupted	-0.611000	-0.398000	No effect
hsa-miR-5572	tcatACCCCAAagtttcta	3	GUUGGGGU	m7b	Created	-0.115000	-0.492000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

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