SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions
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Prediction criteria:	TargetScan sites only     All 6mer or longer seed matches

RefSeq ID:	NM_000043
Gene Symbol:	FAS
Description:	Homo sapiens Fas (TNF receptor superfamily, member 6) (FAS), transcript variant 1, mRNA.
Gene Location:	chr10(+):90750287-90775542
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Somatic mutations that impact miRNA target sites

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014550A>G			COSN5888337		RK190_C01		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-3163	actgggtacATTTTATcat	0	UAUAAAAU	m7b	(m7b->m6c)	-0.009000	no TS	0.020000
hsa-miR-3662	actgggtaCATTTTatcat	5	GAAAAUGA	m6b	Disrupted	0.118000	0.094000	0.290000
hsa-miR-424-3p	actgggtACGTTTTatcat	0	CAAAACGU	m7b	Created	no TS	-0.268000	-0.100000
hsa-miR-548ad	actgggtaCGTTTTatcat	0	GAAAACGA	m6b	Created	no TS	-0.089000	1.000000

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89014996A>G			COSN1124101		HX17T		[liver][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-302a-5p	agaaTTTAAGTaaggctct	2	ACUUAAAC	m7a	Created	-0.041000	-0.041000	No effect
hsa-miR-302a-5p	agaaTTTAAGTaaggctct	0	ACUUAAAC	m7a	Created	-0.041	-0.041	No effect

Mutation			Mutation ID		Sample Name		Cancer Type
chr10:g.89015535C>A			COSN7074141		8013946		[pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID	miRSite	Conservation	miRSeed	SeedClass	FuncClass	Wildtype CS+	Mutant CS+	PITA score change
hsa-miR-1275	tcataCCCCCAagtttcta	1	GUGGGGGA	m6b	Disrupted	-0.573000	-0.377000	0.010000
hsa-miR-3170	tcatACCCCAaagtttcta	2	CUGGGGUU	m6b	Created	-0.173000	-0.371000	No effect
hsa-miR-4665-5p	tcataCCCCCAagtttcta	1	CUGGGGGA	m6b	Disrupted	-0.611000	-0.398000	No effect
hsa-miR-5572	tcatACCCCAAagtttcta	3	GUUGGGGU	m7b	Created	-0.115000	-0.492000	No effect

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.

Germline mutations in target sites of miRNAs in somatic mutation table

Location	SNP ID	Ancestral Allele	Allele	miR ID	Conservation	miRSite	FuncClass	Validation	context+ score change
89015534	rs1468063	C	C	hsa-miR-1275 hsa-miR-4665-5p hsa-miR-6751-5p hsa-miR-6752-5p hsa-miR-6803-5p hsa-miR-6835-5p hsa-miR-6842-5p hsa-miR-7109-5p hsa-miR-7110-5p	1 1 0 0 0 0 0 1 0	ataCCCCCAAgtt ataCCCCCAAgtt atACCCCCAAgtt atACCCCCAagtt atACCCCCAAgtt aTACCCCCAagtt atACCCCCAagtt ataCCCCCAAgtt atACCCCCAagtt	Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted Disrupted	N N N N N N N N N	-0.196 -0.213 -0.452 -0.217 -0.452 -0.486 -0.22 -0.218 -0.227
			T	hsa-miR-1226-5p hsa-miR-6734-5p hsa-miR-6804-5p hsa-miR-6834-5p	1 1 0 1	ataCCCTCAAgtt ataCCCTCAAgtt atACCCTCAagtt ataCCCTCAAgtt	Created Created Created Created	N N N N	-0.178 -0.178 -0.177 -0.174

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