SomamiR DB 2.0 Somatic mutations altering microRNA-ceRNA interactions |
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RefSeq ID: | NM_000135 |
---|---|
Gene Symbol: | FANCA |
Description: | Homo sapiens Fanconi anemia, complementation group A (FANCA), transcript variant 1, mRNA. |
Gene Location: | chr16(-):89803958-89883065 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr16:g.89737887A>A | ICGC_47217 | TCGA-DR-A0ZM-01A-12D-A10S-08 | CervicalSquamousCellCarcinoma(TCGA,US) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-30b-3p |
ttggCTCCCAaatgtcgca |
0 | CUGGGAGG | m6b | Created | -0.068 | -0.168 |
-0.36 |
|
hsa-miR-30c-1-3p |
ttggCTCCCAaatgtcgca |
0 | CUGGGAGA | m6b | Created | no TS | -0.108 |
-4.37 |
|
hsa-miR-30c-2-3p |
ttggCTCCCAaatgtcgca |
0 | CUGGGAGA | m6b | Created | no TS | -0.108 |
-3.54 |
|
hsa-miR-3122 |
ttggcTCCCAAatgtcgca |
0 | GUUGGGAC | m6b | Created | no TS | -0.069 |
-0.01 |
|
hsa-miR-3689a-3p |
ttggCTCCCAaatgtcgca |
0 | CUGGGAGG | m6b | Created | -0.068 | -0.158 |
-0.01 |
|
hsa-miR-3689b-3p |
ttggCTCCCAaatgtcgca |
0 | CUGGGAGG | m6b | Created | -0.068 | -0.165 |
-0.01 |
|
hsa-miR-3689c |
ttggCTCCCAaatgtcgca |
0 | CUGGGAGG | m6b | Created | -0.068 | -0.165 |
-0.01 |
|
hsa-miR-425-3p |
ttggcTCCCGAatgtcgca |
0 | AUCGGGAA | m6b | Disrupted | -0.191 | no TS |
9.01 |
|
hsa-miR-4300 |
ttgGCTCCCAaatgtcgca |
0 | UGGGAGCU | m7a | (m6b->m7a) | -0.194 | -0.383 |
0.33 |
|
hsa-miR-5591-5p |
ttgGCTCCCAaatgtcgca |
0 | UGGGAGCU | m7a | (m6b->m7a) | -0.213 | -0.399 |
0.35 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr16:g.89738005T>C | ICGC_1420159 | TCGA-D1-A167-01A-11D-A12J-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-3937 |
gatgcccgCCGCCTGcact |
0 | ACAGGCGG | m7b | Created | -0.216 | -0.394 |
-3.24 |
|
hsa-miR-3960 |
gatgcCCGCCGCCtgcact |
0 | GGCGGCGG | m8a | Created | no TS | -0.229 |
-0.83 |
|
hsa-miR-4269 |
gatgcccgcTGCCTGCact |
0 | GCAGGCAC | m7a | (m7a->m6a) | NA | NA |
0.14 |
|
hsa-miR-4467 |
gatgccCGCCGCCtgcact |
0 | UGGCGGCG | m7b | Created | no TS | -0.219 |
-2.89 |
|
hsa-miR-4514 |
gatgcccgCTGCCTGcact |
0 | ACAGGCAG | m7b | Disrupted | -0.064 | no TS |
3.52 |
|
hsa-miR-4692 |
gatgcccgCTGCCTGcact |
0 | UCAGGCAG | m7b | Disrupted | -0.064 | no TS |
2.34 |
|
hsa-miR-885-3p |
gatgccCGCTGCCTgcact |
0 | AGGCAGCG | m8a | Disrupted | -0.119 | no TS |
0.34 |
Mutation | Mutation ID | Sample Name | Cancer Type | ||||||
---|---|---|---|---|---|---|---|---|---|
chr16:g.89738085G>A | ICGC_1420160 | TCGA-B5-A11E-01A-11D-A10M-09 | UterineCorpusEndometrioidCarcinoma(TCGA,US) | ||||||
miRNA Targets Table | |||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change | |
hsa-miR-876-3p |
tctcaAACCACCggccaca |
0 | UGGUGGUU | m7b | Created | no TS | -0.113 | No effect |
Mutation | Mutation ID | Sample Name | Cancer Type | |||||
---|---|---|---|---|---|---|---|---|
chr16:g.89738469T>A | COSN4768142 | tumor_4139696 | [haematopoietic_and_lymphoid_tissue][NS][lymphoid_neoplasm][NS] | |||||
miRNA Targets Table | ||||||||
miR ID | miRSite | Conservation | miRSeed | SeedClass | FuncClass | Wildtype CS+ | Mutant CS+ | PITA score change |
hsa-miR-5692a |
ggaatcaATTATTTatgaa |
6 |
CAAAUAAU | m7b | Disrupted | 0.066000 | no TS |
-0.850000 |
hsa-miR-944 |
ggaatcAATAATTTatgaa |
16 |
AAAUUAUU | m8a | Created | -0.046000 | -0.024000 |
-0.060000 |
Location | SNP ID | Ancestral Allele |
Allele | miR ID | Conservation | miRSite | FuncClass | Validation | context+ score change |
---|---|---|---|---|---|---|---|---|---|
89738224 | rs55830337 | G | G |
hsa-miR-3937 hsa-miR-4755-3p |
2 10 |
ttcaCCGCCTGgc ttcaccGCCTGGC |
Disrupted Disrupted |
N N |
-0.216 -0.144 |
89738225 | rs56006529 | C | C |
hsa-miR-3937 |
2 |
cttcaCCGCCTGg |
Disrupted |
N |
-0.216 |
T |
hsa-miR-2682-5p hsa-miR-34a-5p hsa-miR-34b-5p hsa-miR-34c-5p hsa-miR-449a hsa-miR-449b-5p hsa-miR-449c-5p hsa-miR-4514 hsa-miR-4645-5p hsa-miR-4673 hsa-miR-4692 |
2 2 2 2 2 2 2 2 2 2 2 |
cttcACTGCCTgg cttCACTGCCtgg cttcACTGCCTgg cttCACTGCCtgg cttCACTGCCtgg cttCACTGCCtgg cttcACTGCCTgg cttcaCTGCCTGg cttcacTGCCTGG cttcacTGCCTGG cttcaCTGCCTGg |
Created Created Created Created Created Created Created Created Created Created Created |
N N N N N N N N N N N |
-0.039 -0.147 -0.048 -0.137 -0.1 -0.1 -0.057 -0.092 -0.07 -0.098 -0.074 |