SomamiR DB 2.0
Somatic mutations altering microRNA-ceRNA interactions
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PolymiRTS Database

Prediction criteria: TargetScan sites only     All 6mer or longer seed matches

RefSeq ID: NM_000134
Gene Symbol: FABP2
Description: Homo sapiens fatty acid binding protein 2, intestinal (FABP2), mRNA.
Gene Location: chr4(-):120238404-120243316
Browse Pathways

Somatic mutations that impact miRNA target sites



Mutation Mutation ID Sample Name Cancer Type
chr4:g.119318380G>T COSN14471002 8057490 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-1323 gaactgGTTTTGAataatt
0 UCAAAACU m7a Created no TS 0.005000 -0.040000
hsa-miR-4272 gaactggttTTGAATaatt
4
CAUUCAAC m6b Created 0.074000 0.095000 -0.370000
hsa-miR-5003-5p gaactgGTTGTGAataatt
3
UCACAACA m7a Disrupted -0.191000 -0.114000 No effect
hsa-miR-548aa gaacTGGTTTTgaataatt
0 AAAAACCA m7b Created no TS -0.011000 -3.140000
hsa-miR-548ap-3p gaacTGGTTTTgaataatt
0 AAAAACCA m7b Created no TS -0.011000 -0.040000
hsa-miR-548at-3p gaactGGTTTTGaataatt
0 CAAAACCG m7a Created NA NA -1.530000
hsa-miR-548o-3p gaactgGTTTTGaataatt
0 CCAAAACU m6b Created no TS -0.005000 -7.300000
hsa-miR-548t-3p gaacTGGTTTTgaataatt
0 AAAAACCA m7b Created no TS -0.011000 -3.140000

Mutation Mutation ID Sample Name Cancer Type
chr4:g.119318715G>A COSN7772289 ASHPC_0003_Pa_P_2 [pancreas][NS][carcinoma][NS]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4684-5p actgttttcGTAGAGAGag
1
CUCUCUAC m8a (m8a->m7a) -0.091000 no TS -0.030000
hsa-miR-570-3p acTGTTTTCGtagagagag
1
CGAAAACA m8a (m8a->m7b) -0.139000 -0.214000 -0.130000


Mutation Mutation ID Sample Name Cancer Type
chr4:g.119318752G>C COSN9900549 C0096T [kidney][NS][other][neoplasm]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
No TargetScan sites are altered. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.


Mutation Mutation ID Sample Name Cancer Type
chr4:g.119318976A>G COSN167304 GC8_T [stomach][NS][carcinoma][adenocarcinoma]
miRNA Targets Table
miR ID miRSite Conservation miRSeed SeedClass FuncClass Wildtype CS+ Mutant CS+ PITA score change
hsa-miR-4277 accAGAACTGtttatttca
0 GCAGUUCU m7b (m6c->m7b) no TS -0.197000 1.060000
hsa-miR-4277 accAGAACTGtttatttca
0 GCAGUUCU m7b (m6c->m7b) no TS -0.197 1.06

*By default, only target sites identified by TargetScan are displayed. To display all potentially impacted target sites, select "All 6mer or longer seed matches" above.



Germline mutations in target sites of miRNAs in somatic mutation table

Location SNP ID Ancestral
Allele
Allele miR ID Conservation miRSite FuncClass Validation context+
score change
119318710 rs74785845 G G hsa-miR-3183
hsa-miR-4684-5p
hsa-miR-4723-3p
hsa-miR-6769b-3p
hsa-miR-6817-3p
hsa-miR-6873-3p
hsa-miR-6892-3p
hsa-miR-7110-3p
2
1
2
2
2
2
2
2
cgtagAGAGAGGg
cGTAGAGAgaggg
cgtagAGAGAGGg
cgtagAGAGAGGg
cgtAGAGAGAggg
cgtAGAGAGAggg
cgtagaGAGAGGG
cgtaGAGAGAGgg
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
Disrupted
N
N
N
N
N
N
N
N
-0.134
-0.091
-0.125
-0.134
-0.05
-0.093
-0.218
-0.196
A hsa-miR-130b-5p
2
cgtaGAAAGAGgg
Created
N
-0.084
119318976 rs2964 G A hsa-miR-148b-5p
hsa-miR-3121-3p
hsa-miR-3168
hsa-miR-5584-3p
hsa-miR-6874-3p
0 AGAACTAtttatt
agaaCTATTTAtt
AGAACTAtttatt
AGAACTAtttatt
AGAACTAtttatt
Created
Created
Created
Created
Created
N
N
N
N
N
-0.167
-0.021
-0.123
-0.108
-0.162
G hsa-miR-4277
0 AGAACTGtttatt
Disrupted
N
-0.197

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